A device comprising a heat-generating component that comprises an alkali metal is provided. The alkali metal in the presence of water at a point of contact of the device undergoes an exothermic reaction to generate heat in situ. The amount of heat generated is proportional to and/or limited by the amount (or moles) of water at the point of contact, and the heat generated is sufficient to achieve an increase in temperature at the point of contact to achieve a therapeutic or beneficial result. In one embodiment, the device is used for reducing sweat production in a subject suffering from excessive sweating or hyperhidrosis. In other embodiments, the device is used to substantially sterilize a surface or render a surface substantially aseptic.

The present invention is directed to a thermo-regulation device for treating an area with in need of thermal regulation. The invention includes a device configured to be fitted over an area in need of thermal regulation; wherein a plurality of cells are integral to the covering body, each cell is equipped with at least one of a plurality of reactants. Each cell of the present invention is in one configuration joined to a neighboring cell by a destructible barrier. The reactants are configured to produce a thermal event when combined with at least one other reactant.

An economical dual modality system can be manufactured and used in a method including the steps of assembling a system including a durable energy subsystem and a replaceable thermal subsystem, activating the replaceable thermal subsystem, attaching the system to a desired treatment area of a user's body, and activating the durable energy subsystem. The durable energy subsystem is arranged and configured to deliver energy, and the replaceable thermal subsystem is arranged and configured to be coupled to the durable energy subsystem arranged and configured to deliver thermal energy. The replaceable thermal subsystem delivers thermal energy to the desired treatment area at a predetermined temperature range for at least 30 minutes, and the durable energy subsystem delivers energy from the group consisting of non-visible light electromagnetic radiation, visible light radiation, electromagnetic field, microcurrent, electrical stimulation, iontophoresis, sonophoresis and combinations thereof independently of the thermal energy.

An economical dual modality system can be manufactured and used in a method including the steps of assembling a system including a durable energy subsystem and a replaceable thermal subsystem, activating the replaceable thermal subsystem, attaching the system to a desired treatment area of a user's body, and activating the durable energy subsystem. The durable energy subsystem is arranged and configured to deliver energy, and the replaceable thermal subsystem is arranged and configured to be coupled to the durable energy subsystem arranged and configured to deliver thermal energy. The replaceable thermal subsystem delivers thermal energy to the desired treatment area at a predetermined temperature range for at least 30 minutes, and the durable energy subsystem delivers energy from the group consisting of non-visible light electromagnetic radiation, visible light radiation, electromagnetic field, microcurrent, electrical stimulation, iontophoresis, sonophoresis and combinations thereof independently of the thermal energy.

A dual modality system includes a flexible chassis including a durable energy subsystem and a replaceable thermal subsystem. The durable energy subsystem has a plurality of energy emitters disposed in an emission region of the chassis having a length and a width, wherein the emission region length and emission region width are both substantially greater than an emission region depth. The replaceable thermal subsystem has a thermal source affixed to flexible web having an adhesive surface and at least one structure arranged and configured to couple the thermal subsystem to a chassis comprising a durable energy subsystem in a configuration wherein the thermal source is substantially superposed over the emission region of the chassis.

A dual modality system includes a chassis having a receptacle and means to couple the chassis to a desired treatment area of a user's body; a durable energy subsystem coupled to the chassis, arranged and configured to deliver energy to the desired treatment area of a user's body; and a replaceable thermal subsystem arranged and configured for removable placement in the receptacle of the chassis, arranged and configured to deliver thermal energy.

A scrotal sheet includes a paste/water-retaining material layer containing at least moisture and a cooling material that uses vaporization heat resulting from evaporation of the moisture, a surface material layer on a surface of the paste/water-retaining material layer, and a notch configured to from a three-dimensional shape to surround the scrotum when the scrotal sheet is used.

A scrotal sheet includes a paste/water-retaining material layer containing at least moisture and a cooling material that uses vaporization heat resulting from evaporation of the moisture, a surface material layer on a surface of the paste/water-retaining material layer, and a notch configured to from a three-dimensional shape to surround the scrotum when the scrotal sheet is used.

An object of the present invention is to provide a heat-generating device with which a warm sensation is persistently perceived, and which can effectively exert a heating effect. In a heat-generating device that is used by being attached to skin, (1) a packaging material constituting a skin attachment surface of a housing is formed of a laminated sheet in which at least a moisture absorption layer that absorbs moisture and a moisture barrier layer that blocks penetration of moisture are laminated in this order from the adhesive layer, (2) an adhesive layer is partially provided on a surface of the moisture absorption layer, and (3) a warming agent that allows an enhanced warm sensation to be perceived in the presence of moisture is contained in at least one of the adhesive layer and the moisture absorption layer. This heat-generating device thereby has improved persistence of a perceived warm sensation, and can exert a markedly high heating effect.

An object of the present invention is to provide a heat-generating device with which a warm sensation is persistently perceived, and which can effectively exert a heating effect. In a heat-generating device that is used by being attached to skin, (1) a packaging material constituting a skin attachment surface of a housing is formed of a laminated sheet in which at least a moisture absorption layer that absorbs moisture and a moisture barrier layer that blocks penetration of moisture are laminated in this order from the adhesive layer, (2) an adhesive layer is partially provided on a surface of the moisture absorption layer, and (3) a warming agent that allows an enhanced warm sensation to be perceived in the presence of moisture is contained in at least one of the adhesive layer and the moisture absorption layer. This heat-generating device thereby has improved persistence of a perceived warm sensation, and can exert a markedly high heating effect.