This disclosure relates to subnormothermic machine perfusion formulations for ex vivo preservation of allografts, and methods of use thereof.

A continuous refrigeration system for kidney transplantation surgery includes: a kidney bag, an extracorporeal ring and an intracorporal ring. One end of the kidney bag is provided with a bag mouth that allows the kidney and crushed ice to enter the interior of the kidney bag; the extracorporeal ring and the intracorporal ring are spaced on the kidney bag, and a lead-out end is provided both outside and inside the bottom of the kidney bag. A partial length of the kidney bag is supported to form the through circulation passage through which the kidney enters the kidney bag and thus obtaining a carrier for entering the human body, making the operation simple, convenient and fast. The lead-out end is provided so that the kidney bag is adapted to laparoscopic surgery.

The present disclosure provides an organ supporting device and a manufacturing system thereof. The organ supporting device includes a tube with a one or more bends to create two supporting regions for an organ. The supporting regions are connected via a connecting region. The tube is supplied with temperature control material, such as a cooling fluid, by a circulation component. The temperature of the organ and fluid are sensed by one or more sensors and the sensed temperatures are provided to a temperature control unit to increase or decrease the temperature of the temperature control material to maintain a temperature of an organ for in-vivo or ex-vivo surgical procedures.

An organ container has a contractible and expandable pouch-shaped body having an opening. Under no-load conditions, the opening has a maximum width smaller than a maximum width of the body. The opening is expandable up to a state in which the maximum width of the opening is greater than the maximum width of the body. The body has an inner surface that includes a first region having a smooth curved surface and a second region having an uneven shape. The uneven shape of the inner surface of the body allows a preservation solution to protrude into interstices between an organ and the inner surface and thereby improves a thermal insulating effect. Moreover, by providing the smooth first region, generation of remaining traces can be suppressed. Accordingly, it is possible to effectively suppress a temperature rise in the organ and to reduce damage to the organ.

The invention discloses an apparatus for adjusting the temperature of a body comprising a sheath for providing a channel from outside said body to a cavity inside said body, where said sheath comprises a guiding section being angular to said channel. The apparatus further comprises a heat exchange unit comprising an inlet and an outlet, an outer contour and an inner fluid channel, adapted for inserting through said channel of said sheath.

A method and apparatus are disclosed for regulating a temperature of an esophagus when heat or cold is delivered to a left atrium, the method including altering a heat exchange device from an insertable configuration to a heat exchanging configuration which conforms and corresponds with a cross-section of an inside of the esophagus such that the esophagus is maintained in its natural shape and location. In some embodiments the heat exchange device has a heating/cooling balloon which is inflated to be in the heat exchanging configuration. Some alternative embodiments includes altering the configuration of the balloon to conform to or correspond with the cross section of an esophagus by means other than inflation.

This is a device, belonging to the medical and hospital artifacts industry, developed to accelerate the hemostatic process for patients undergoing radial punctures, partially compressing the artery subjected to treatment; said cryo-hemostatic device is essentially presented in the form of a wristband (1), providing end bands (2) providing velcro-based closing, interconnected by an intermediate band (3) below which a first cryogenic reservoir pad is located (4), which can be filled with a saline substance by the action of a syringe connected to the first connection nipple (5) attached to the first tube (6), flanked by the second external reservoir pad (7), also provided with a second connection nipple (8), attached to the second tube (9).

There is provided a device for insertion into a body cavity, the device includes an insertion member configured to be inserted into the body cavity, an expandable member coupled to the insertion member, the expandable member capable of being expanded to apply pressure onto tissue within the body cavity, a first member configured for storing a first endothermic reactant therein, and a second member configured for storing a second endothermic reactant therein. In particular, the first and second members are configured to, in a state of the device (e.g., compressed state), allow the first and second endothermic reactants to cooperate to effect an endothermic reaction to generate an endothermic product. Furthermore, the expandable member is configured to receive at least one of the first or second endothermic reactant and the endothermic product through a channel within the insertion member. There is also provided a method of fabricating a device for inserting into a body cavity.

Techniques are provided for the monitoring and transport of an anatomical organ with a sleeve arranged snuggly around the organ and comprising a porous material with respect to an aqueous solution in a container affixed to unmanned aerial vehicle. As a non-limiting example, in a first set of embodiments, the sleeve, shaped to an approximate shape of the target anatomical organ has an opening for inserting the target anatomical organ. The sleeve may comprise a fabric that is porous with respect to an aqueous solution and has a tensile strength to hold the weight of the sleeve and of the target anatomical organ. In other embodiments, the fabric of the sleeve may also include a different second opening for passing a blood vessel for the target anatomical organ. Further, the sleeve may include a wireless communication device and a at least one of a temperature sensor and vibration sensor.

Devices are provided for regulating the temperature of an organ being transplanted that includes a housing including one or more walls surrounding a cavity sized to receive an organ and an opening for accessing the cavity. The walls include an inner layer defining an inner surface for contacting the organ placed in the cavity, an outer layer defining an outer surface of the housing, and a cooling layer between the inner and outer layers, e.g., including a phase-change material configured to absorb thermal energy from the organ within the cavity through the inner layer, e.g., to maintain the organ within a target temperature range before and/or during a transplantation procedure. Optionally, the device may include one or more additional features, e.g., a handle to facilitate manipulation, one or more straps securable across the opening to secure the organ, and/or a temperature sensor to monitor the temperature of the organ.