Systems, methods and devices for utilizing heat transfer parameters or energy expenditure of devices providing controlled hypothermia, normothermia or hyperthermia to detect changes, or the absence of changes, a patient's endogenous set-point temperature; which is not available during exogenously induced targeted temperature management. A particular embodiment would allow detection of fever in patients undergoing targeted temperature managed.

A medical device is disclosed. The medical device may include an elongate member having a lumen extending at least partially between a proximal end and a distal end of the elongate member. The medical device may also include a plurality of legs coupled to a distal portion of the elongate member, and a distal end piece connected to each of the plurality of legs and located distally to the distal end of the elongate member. The medical device may also include an actuating member coupled to the distal end piece and extending between the plurality of legs and through the lumen. The reciprocal movement of the actuating member may be configured to reversibly move the plurality of legs from a first position to a second position. The medical device may also include a stopping member coupled to the actuating member and configured to limit a movement of the actuating member.

A catheter and methods for luminal therapy are provided wherein a catheter includes an elongated catheter shaft having a proximal end and a distal region, a first inflation lumen and a second inflation lumen extending from the proximal end to the distal region; a fluid impermeable balloon affixed to the distal region; an intermediate balloon affixed to the distal region to envelop the fluid impermeable balloon, the intermediate balloon having a first multiplicity of through-wall apertures; and an outer balloon affixed to the distal region to envelop the intermediate balloon, the exterior surface of the outer balloon comprising a coating of an agent; wherein the first inflation lumen is coupled to a first space enclosed by the fluid impermeable balloon, the second inflation lumen is coupled to a second space defined by the fluid impermeable balloon and the intermediate balloon, wherein the fluid impermeable balloon is configured to contact and expand the intermediate balloon against the outer balloon, and to expand the outer balloon such that the coating is in contact with a luminal wall. The outer balloon also may include a multiplicity of through-wall apertures.

A medical imaging system is described that comprises an heating element configured to apply at least one heating pattern element to a material to locally heat the material; a sensor configured to capture the position of the heated material a predetermined time after the application of the heating pattern element; and circuitry configured to determine the change of the heating pattern applied to the material based upon the captured position of the heated material after the predetermined time.

A quick-connector for use with an autoretroperfusion and hypothermia system and methods of using the connector. The connector comprises a coolant inlet, a coolant outlet, a coolant reservoir, a blood lumen outlet, a blood lumen inlet, and a blood lumen, whereby the coolant outlet is configured to accept a cooling product from the reservoir, the reservoir is configured to accept cooling product from the coolant inlet. Flowing blood powered by the patient's heart may enter the connector through the blood lumen inlet, travel through the blood lumen while being cooled by cooling product in the reservoir, and leave the connector through the blood lumen outlet. The temperature of blood leaving the connector can be measured at the blood lumen outlet. Catheters can be attached to the blood lumen inlet and blood lumen outlet to receive and send blood, respectively. A cooling system can be attached to the coolant inlet and coolant outlet to provide a source of cooling product.

Devices and methods for cooling all or part of the body of a human or animal subject by inserting a heat exchange catheter into the subject's body and infusing into or through the catheter a heat exchange medium that contains liquid phase matter and frozen solid phase matter, wherein at least some of the solid phase matter melts while in the catheter.

A probe intended to be at least partially implanted in a living being, with a view to locally cooling at least one region of the living being, this probe notably including a cooling member present at its distal end, which member is intended to make contact with the region to be cooled, and a thermoelectric cooling module including a cold region making contact with the cooling member.

Methods and system for atrial fibrillation mapping utilizing cardiac mapping based on medical image(s). The methods and system also adapted for any balloon based catheters including cryoballoon catheter, laser balloon catheter, or “hot balloon” catheter, as well as circular catheters. The methods and system includes overlaying of two or more images on top of each other (where the images are of various types or modalities) and aligning the images, where the transparency between the images can be adjusted for navigating and optimal placement of the balloon based catheters or circular catheters. The cardiac system also adopted for guiding optimal placement of the left ventricular (LV) lead placement for cardiac re-synchronization (CRT) therapy, and for mapping and displaying activation times from various branches of the coronary sinus for optimizing CRT therapy.

A tracheal tube include a conformable conduit that forms a respiratory passage to transfer respiratory gases to a patient. A helical inflatable lumen is formed in or on an interior surface of the conformable conduit. Fluid transferred into the helical inflatable lumen causes the inflatable lumen to assume an expanded configuration to expand an outer diameter of the conformable conduit relative to an unexpanded configuration of the helical inflatable lumen. When in the expanded configuration and inserted in a patient, conformable walls of the conformable conduit expand outwards to contact the tracheal walls such that the conformable conduit is self-sizing to a patient's trachea size.

Methods and systems for generating sterile slurry are provided. The slurry may be injected into subcutaneous fat of a subject to facilitate weight reduction or improve cosmetic appearances. Systems for generating a slurry comprise a repository for receiving a solution, a generator for generating the slurry from the solution, and a port for transferring the slurry from the system. Methods for generating a slurry comprise receiving a solution in a slurry generator, and generating slurry from the solution, wherein the slurry comprises ice particles capable of flowing through a cannula. Systems include continuous flow systems, agitated systems, and hybrid continuous flow and agitation systems.