A cryo-system for treating a body part of an individual by cryotherapy, which includes two parts. The first part is either i) a cryo-probe suitable for internal cooling, which includes a penetrating segment in communication with a cryogen source and is at least smaller than 1/10th of the body part's biggest volume and/or at least one dimension smaller than 1 cm or ii) a cryo-probe suitable for external cooling, which includes a non-penetrating segment in communication with a cryogen source. The second part is either i) an assembly of at least two nanoparticles bound to each other or associated with each other via binding or associating material or ii) at least one nanoparticle, which includes iron and at least one other metal than iron. The assembly of at least two nanoparticles or the at least one nanoparticle may be cooled by the cryo-probe or by switching on the cryo-probe.

An enclosure or plenum that supports a looped pump tube is hingedly connected to a framed thin-walled heat exchange bag through which working fluid from an intravascular heat exchange catheter flows. The frame with bag can be inserted between cold plates to exchange heat with the working fluid flowing through the bag. With the framed bag between the plates, the looped pump tube from the enclosure or plenum is receivable in the raceway of a peristaltic pump, which pumps working fluid through the system.

Devices, systems and methods for controlling a patient's body temperature by endovascular heat exchange.

A catheter provides temperature management for a target body. A system provides for target temperature management and a method allows for target body temperature management. The target body temperature management may be performed in cavities, such as the nasopharynx route, of a body.

Embodiments described herein are directed to methods of treating visceral fat where the method includes the steps of identifying visceral fat to be treated, inserting a laparoscopic device into the visceral fat to be treated, inserting a treatment instrument into the laparoscopic device such that a distal treatment section of the treatment device is delivered into the visceral fat, cooling the distal treatment section and the visceral fat adjacent to the distal treatment section to a cooling temperature no colder than approximately −20° C., and wanning the distal treatment section and the visceral fat adjacent to the distal treatment section to a temperature greater than the cooling temperature.

A device to change the temperature of a localized volume of material. A workable device includes at least one heat transfer mechanism having an external surface for direct contact with an exposed surface of the material. A working fluid is directed by input and output conduits to contact an internal surface of the heat transfer mechanism. The heat transfer mechanism exchanges heat between the working fluid and the material. Temperature of the working fluid may be regulated by a thermal system disposed at a remote location. An optional temperature sensing element may monitor a local temperature of the heat transfer mechanism or otherwise infer a temperature of a portion of the material. Sometimes, a device includes a cooperating anchoring arrangement to facilitate holding the heat transfer mechanism in a desired spot. Certain devices may be plastically deformed to a desired device shape.

A system and method for adding or removing heat from a heat exchange fluid circulating between an external heat exchanger and an intravascular heat exchange catheter is described. The system includes a two stage cooling system providing for a high rate of cooling in one stage and a lower rate of cooling in a second stage. Both stages may be used to provide maximal cooling while the second stage is used to provide improved control of the cooling rate as a target temperature is approached. The second stage may also be used to provide heat to the heat exchange fluid.

Methods and for treatment of cancer and other diseases including complications from late stage viral infections by inducing hyperthermia in a patient relying on withdrawing blood from the patient and returning the withdrawn blood to the patient to establish an extracorporeal flow circuit. Blood is heated by passing through the extracorporeal circuit at a controlled rate until a target body core temperature in is achieved. Usually, the blood will be subjected to a continuously re-circulating dialysis to balance electrolytes. Additionally, the blood will be subjected to a continuously recirculating regeneration through a carbon sorbent column where toxins and contaminants are removed. The blood temperature is maintained at the target blood temperature for a treatment period, and the blood is cooled after the treatment period has been completed. The method can also be effective in treating rheumatoid arthritis, scleroderma, hepatitis, sepsis, the Epstein-Barr virus, and patients with life threatening complications from other viruses, including the COVID-19 virus. A method for removing viruses from the blood supply in an external circuit is also presented.

Systems and methods for generating slurry for injection are provided. Systems comprise a container and a device. The container comprises a solution for administration via an injection needle of a predetermined size. The device is capable of receiving the solution and producing a slurry having ice particles capable of flowing through the injection needle. Methods comprise selecting a container having the solution, receiving the solution in the device, and producing, in the device, the slurry having ice particles capable of flowing through the injection needle.

A medical fluid probe includes a heat spreader structure that defines therein a fluid chamber that is in fluid communication with an external environment around the probe, and a thermal energy source in thermal communication with the heat spreader structure. The heat spreader structure functions as both temperature-control elements and structural elements. A variety of separate structure elements, such as the heat pipes, may combine to form the heat spreader structure. The thermal energy source may be used to maintain the temperature of the heat spreader structure, such as by heating and/or cooling the heater spreader structure.