Cooling systems are described herein that may be used in connection with one or more attached devices to cool patient tissue. The disclosed cooling systems include a refrigeration unit containing a thermoelectric element in thermal communication with a heat exchanger, a fluid pump in fluid communication with a fluid inlet and a fluid outlet, tubing connecting the fluid inlet to the fluid outlet, a fluid cooling element in thermal contact with the thermoelectric element, and a temperature sensor positioned to detect a temperature of fluid within the tubing. The temperature of fluid within the tubing can be controlled by a control unit having a user interface and a power controller to adjust cooling power to the thermoelectric element. Various types of devices can be configured to receive and circulate cooled fluid from the cooling systems, such as retractor blades, retractor shims, cooling pads, and scope sheaths.

An intravascular temperature management catheter includes a shaft through which working fluid can circulate to and from a proximal location on the shaft. The catheter extends from a connector hub. At least one heat exchange member is supported by a distal part of the shaft or other part of the catheter to receive circulating working fluid from the proximal location. A temperature sensor is supported on the catheter for generating a temperature signal representative of blood temperature to a control system. The temperature sensor includes first and second conductive leads having respective first and second distal segments on or in the catheter shaft. The first and second distal segments are arranged to be in thermal contact with blood flowing past the catheter when the catheter is disposed in a blood vessel of a patient. Also, the temperature sensor includes a joining body connected to proximal segments of the first and second leads. The joining body may be supported in the hub or in another location proximal to the first and second conductive leads.

A working fluid cassette for an intravascular heat exchange catheter includes a frame holding two closely spaced, square polymeric membranes in tension. Working fluid from the catheter is directed between the membranes. The cassette is closely received between two refrigerant cold plates to exchange heat with the working fluid, which is circulated back to the catheter.

The present disclosure provides a device and a method for cooling living tissues for a medical purpose and other purposes. The cooling device comprises: a container configured to accommodate a cooling medium and thermally coupled with the cooling medium by directly contacting the cooling medium; a cooling generator configured to be thermally coupled with the container by a direct contact and thereby to provide cooling energy to the cooling medium; and a heat sink dissipating heat from the cooling generator, the heat sing being configured to be spaced apart from the cooling generator and to be thermally coupled with the cooling generator without a direct contact with the cooling generator.

This application provides a preparation method of a heating fluid used for biological targeted hyperthermia, a heating fluid preparation device, a biological targeted hyperthermia apparatus, and a control method of the biological targeted hyperthermia, in which the biological targeted hyperthermia apparatus includes: a heating fluid injection device configured to inject a heating fluid into a body circulatory system of a therapy subject; a microwave radiation device configured to provide microwave radiation with a set wavelength and a set frequency; a microwave imaging temperature-measuring device configured to detect a temperature and a position of the heating fluid in the therapy subject, and output a thermal imaging signal; and a control device used for receiving the thermal imaging signal and controlling the microwave radiation device to output the microwave radiation with the set wavelength and the set frequency.

An apparatus for controlling the movement of bile and/or gallstones in the biliary duct of a patient, that comprises an implantable constriction device for gently constricting (i.e. without substantially hampering the blood circulation in the tissue wall) at least one portion of the tissue wall to influence the movement of bile and/or gallstones in the biliary duct, and a stimulation device for stimulating the wall portion of the tissue wall. A control device controls the stimulation device to stimulate the wall portion, as the constriction device constricts the wall portion, to cause contraction of the wall portion constricted by the constriction device to further influence the movement of bile and/or gallstones in the biliary duct. The apparatus can be used for actively moving the gallstones in the lumen, with a low risk of injuring the biliary duct.

A conformable garment or device, for example, for performing heat exchange with a patient, includes one or more tubes. At least one of the one or more tubes has a lumen configured to receive fluid for flowing through the lumen of that tube to heat or cool the tube. The one or more tubes may be coupled to form a conformable fabric or material, such that the conformable fabric or material conforms to a non-planar shape. The conformable garment or device may conform to cover a particular portion of the patient's body to heat or cool the patient's body.

In some implementations, data obtained by a temperature management system for delivering temperature management therapy to a patient is presented, within a single display region, as a graph of patient temperature over time representing the timespans of all phases of a multi-phase temperature management therapy. The graph may be fitted to present each phase separately in a manner that retains data complexity. The graph may include power data representing power output over time by a temperature management device. Data from other devices may be incorporated into the graph. A portion of the data may be patient temperature data and/or patient physiological data gathered during a time preceding temperature management therapy by the temperature management device.

Compositions, systems and methods are provided for the treatment of subcutaneous brown or beige fat or visceral brown or beige fat, wherein the compositions comprise a cold solution comprising liquid water and/or ice particles, and optionally one or more additives and/or pharmacologic agents. The treatment of subcutaneous or visceral brown or beige fat provides activation of brown adipocytes, proliferation of brown adipocytes, increased volume of brown adipocytes, differentiation of precursors into beige and/or brown adipocytes, activation of beige adipocytes, stimulation of beige adipocytes and/or cryolipolysis of white adipocytes. The methods of treatment result in increased metabolic health, weight loss, and improved health.

A medical fluid probe includes a heat spreader structure that defines therein a fluid chamber that is in fluid communication with an external environment around the probe, and a thermal energy source in thermal communication with the heat spreader structure. The heat spreader structure functions as both temperature-control elements and structural elements. A variety of separate structure elements, such as the heat pipes, may combine to form the heat spreader structure. The thermal energy source may be used to maintain the temperature of the heat spreader structure, such as by heating and/or cooling the heater spreader structure.