A method is provided for in-situ cooling of biological tissue within the body, the biological tissue being selected from the group consisting of organ tissue, blood vessel tissue and combinations thereof. The method comprises establishing a heat-conducting contact between a heat absorption zone of a cooling unit of a device for in-situ cooling of biological tissue and the biological tissue within the body, transporting thermal energy from the heat absorption zone of the cooling unit via a substance for transporting thermal energy, which is arranged within a hollow tube of the device for in-situ cooling of biological tissue, to a cooling device of the device for in-situ cooling of biological tissue, and releasing the thermal energy via the cooling device. The method allows protecting biological tissue within the body in a location-selective manner from cancer-therapy-caused damage during cancer therapy in a simple, cost-effective and low-risk manner.

In an example, a cryotherapy device includes an elongated shaft, and a cryotherapy delivery member coupled to a distal end of the elongated shaft. The cryotherapy delivery member is configured to apply, from a fixed position in a nasal cavity, thermal energy to at least one of a plurality of nerves in the nasal cavity or a plurality of branches of a nerve in the nasal cavity.

A process and related assemblies for delivering slush through a tube towards a patient. Obtaining an elongated container partially filled with slush with a port end that has a first port and a second port. Placing the first port in fluid communication with tubing for delivery of slush towards the patient. Placing the second port in fluid communication with a source of gas which may be air. Subjecting the elongated container to automated repetitive movements so that the slush in the partially filled elongated container moves against interior surfaces within the elongated container. Ideally, two different forms of repetitive motion are used to impose complex movement upon the slush within the elongated container. Applying a pressure gradient to cause slush to flow out of the first port towards the patient. The elongated container may be made from a slush bottle with a reversibly engaged cap with the two ports.

A medical system that includes a temperature scanning device configured to identify and locate blood vessels by obtaining a thermal image from a skin surface where blood flowing within blood vessels beneath the skin surface has been altered to define temperature variations of the skin. The system includes a console configured to communicate with the temperature scanning device, the console including processors and logic that, when executed by the processors, causes operations including defining the thermal image. The system may further include a camera, and/or an ultrasound probe. The thermal image may be portrayed on various forms of a display include augmented reality glasses. The thermal image may be overlayed onto a camera image and/or an ultrasound image.

A temperature management system controls a temperature of a body of a patient and determines a value indicative of a thermoregulatory activity of the patient. The system includes a heat exchange system configured to exchange heat with a body of a patient and to record operational data while controlling the temperature of the body of the patient. The temperature management system receives temperature data from a sensor, controls the heat exchange system to maintain the temperature of the body of the patient within a target temperature range, receives, in response to the controlling, operational data, determines, based on the temperature data and the operational data, a value indicative of a thermoregulatory activity of the patient, and generates, based on the value, an alert through the user interface indicating the thermoregulatory activity of the patient.

A clinical grid electrode system for seizure control through local cooling, mapping brain function and me provision of reversible functional ablation. The system includes a modular, scalable, cooling and sensing array composed of a plurality of cooling sensing elements. The system also includes a control system to which die cooling and sensing array is coupled for providing for control and monitoring of die cooling sensing elements making up the cooling and sensing array.

A method and apparatus for manipulating a temperature set-point of a human or homeothermic-animal for increasing or decreasing the body temperature above or below the prevailing body temperature for therapeutic purposes. The method includes the steps of warming or cooling sphenoid sinuses externally resulting in manipulation of the temperature of the pituitary gland which in turn results in manipulation of the body-temperature set-point and the body temperature manipulates accordingly to the new temperature set-point. A heat exchange medium can be used to warm or cool sphenoid sinuses and thus the pituitary gland. The heat exchange fluid can be liquid, or gas maintained at a predetermined temperature. Alternatively, a temperature-controlled probe can be used that upon contact with the sphenoid sinuses provides for the heat exchange.

Embodiments of the present invention are directed to the treatment of hypertension, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, urological disease, cancers, tumors, pains, asthma, pulmonary arterial hypertension, and chronic obstructive pulmonary disease by delivering of an effective amount of formulations at desired temperature to target tissue. The formulations include gases, vapors, liquids, solutions, emulsions and suspensions of one or more ingredients. The temperature may enhance safety and efficacy of the formulations for the treatments. The amounts of the formulation and/or energy are effective to injury or damage the tissues to have a benefit of symptom relive.

Systems, methods and devices for utilizing heat transfer parameters or energy expenditure of devices providing controlled hypothermia, normothermia or hyperthermia to detect changes, or the absence of changes, a patient's endogenous set-point temperature; which is not available during exogenously induced targeted temperature management. A particular embodiment would allow detection of fever in patients undergoing targeted temperature managed.

Methods for treating eating disorders and for reducing a risk associated with developing an eating disorder in patients via therapeutic renal neuromodulation and associated systems. Renal sympathetic nerve activity can be attenuated to improve a patient's eating disorder status or risk of developing an eating disorder. The attenuation can be achieved, for example, using an intravascularly positioned catheter carrying a therapeutic assembly configured to modulate the renal sympathetic nerve.