The present invention relates to wine lees and derivatives thereof. Likewise, it relates to their use in medicine.

The present invention relates to a textile washing agent, in particular a liquid textile washing agent, comprising a) at least one protease, wherein the protease has proteolytic activity and comprises an amino acid sequence which has at least 70% sequence identity with the amino acid sequence given in SEQ ID NO:1 over its entire length and, in each case based on the numbering according to SEQ ID NO:1, has (i) at the positions that correspond to positions 9, 130, 133, 144, 217, 252 and 271, amino acid substitutions, in particular the amino acid substitutions 9T, 130D/V, 133A, 144K, 217M, 252T and 271E, and (ii) at at least one, preferably at least two, of the positions that correspond to positions 6, 89, 131, 166, 189, 211 or 224, at least one additional amino acid substitution, in particular selected from 6W/F, 89A/G, 131H/Y/F, 166M/L/I, 189T/L/I, 211N/Q and 224A/G, more preferably selected from 6W, 89A, 131H, 166M, 189T, 211N and 224A, and b) at least one washing agent ingredient, preferably in an amount of from 0.01 to 99.9 wt.%, wherein the textile washing agent has a pH of from approximately 9 to approximately 12, measured in a 1 wt.% solution in deionized water at 20° C. The present invention also relates to corresponding methods for cleaning textiles, in which methods agents according to the invention are used, and to uses of agents according to the invention for removing protease-sensitive stains from textiles.

The present invention relates to a textile washing agent, in particular a liquid textile washing agent, comprising a) at least one protease, wherein the protease has proteolytic activity and comprises an amino acid sequence which has at least 70% sequence identity with the amino acid sequence given in SEQ ID NO:1 over its entire length and, in each case based on the numbering according to SEQ ID NO:1, has (i) at the positions that correspond to positions 9, 130, 133, 144, 217, 252 and 271, amino acid substitutions, in particular the amino acid substitutions 9T, 130D/V, 133A, 144K, 217M, 252T and 271E, and (ii) at at least one, preferably at least two, of the positions that correspond to positions 6, 89, 131, 166, 189, 211 or 224, at least one additional amino acid substitution, in particular selected from 6W/F, 89A/G, 131H/Y/F, 166M/L/I, 189T/L/I, 211N/Q and 224A/G, more preferably selected from 6W, 89A, 131H, 166M, 189T, 211N and 224A, and b) at least one washing agent ingredient, preferably in an amount of from 0.01 to 99.9 wt.%, wherein the textile washing agent has a pH of from approximately 9 to approximately 12, measured in a 1 wt.% solution in deionized water at 20° C. The present invention also relates to corresponding methods for cleaning textiles, in which methods agents according to the invention are used, and to uses of agents according to the invention for removing protease-sensitive stains from textiles.

The present invention relates to compositions comprising protease variants suitable for use in cleaning or detergent compositions, such as laundry detergent compositions and dish wash compositions, including automatic dish wash compositions.

The present invention relates to subtilase variants suitable for use in, e.g., cleaning or detergent compositions, such as laundry detergent compositions and dish wash compositions, including automatic dish wash compositions. The present invention also relates to isolated DNA sequences encoding the variants, expression vectors, host cells, and methods for producing and using the variants of the invention.

The present invention relates to subtilase variants suitable for use in, e.g., cleaning or detergent compositions, such as laundry detergent compositions and dish wash compositions, including automatic dish wash compositions. The present invention also relates to isolated DNA sequences encoding the variants, expression vectors, host cells, and methods for producing and using the variants of the invention.

The present invention relates to a novel polypeptide which displays IgG cysteine protease activity, and in vivo and ex vivo uses thereof. Uses of the polypeptide include methods for the prevention or treatment of diseases and conditions mediated by IgG, and methods for the analysis of IgG.

The present invention relates to a novel polypeptide which displays IgG cysteine protease activity, and in vivo and ex vivo uses thereof. Uses of the polypeptide include methods for the prevention or treatment of diseases and conditions mediated by IgG, and methods for the analysis of IgG.

Disclosed is a method for controlling the carbon feed to a fed-batch fermenter based on the disturbance of the pH signal following the addition or a limiting substrate.

An agent and a method for cleaning textiles or hard surfaces are provided herein. In one embodiment, the agent includes a first protease and at least one second protease. The first protease Includes an amino acid sequence that is at least about 80% identical to the amino acid sequence indicated in SEQ ID NO.1. The second protease is any protease that is different from the first protease. In another embodiment, the method includes activating proteolytically the first protease and the at least one second protease.