Described are systems and methods for preventing, diagnosing, and/or treating one or more medical conditions. The medical conditions can be ocular and/or neurological diseases, disorders, and/or conditions. The systems and methods can employ a microstimulator that is configured to be placed within an anatomical structure of a subject. The microstimulator can be capacitively linked to an external electronic device to provide neuromodulation to a biological target site proximal to the anatomical structure. The microstimulator can include a body and an electrically conductive insert arranged within the body to create a capacitively coupled link with the external electronic device. The electrically conductive insert can receive a power signal from an external electronic device and convert the power signal to deliver a therapy signal to the biological target site.

This invention is a handheld multipurpose device for standardizing intraocular access for injecting into or obtaining substance(s), content(s), medicine(s), or sample(s) from a human eye(s) or an animal eye(s), in any age group(s), once a specific marker(s) is placed at corneal scleral Limbus. The device is comprising an elongated handle connected to a body having a walled structure with no spaces, one or more space(s) at the bottom; a predesigned curvature(s) in the said device to aid in placement on the surface of the eye; a set or more of track(s) with entry and exit port(s) travelling within the wall(s) at a certain angle and length; a groove that outlines the outer walls limited above and below by projections; a needle hub adapter(s) and/or receiver(s) that allows universal attachment of any injecting device(s) with an opening to the bottom of the device; a projecting marker(s) on one or more sides that indicates where the whole device should rest on the eye at the Cornea-Sclera junction called Limbus; a large opening/window at the bottom of the said device allowing access to all structures of the anterior segment of the eye; and a larger opening(s) and/or window(s) allowing a reservoir function, as well as access to posterior segment and a set of repeated projections from the underside of the device to facilitate gripping to the eye tissue underneath.

A droplet dispensing assembly includes a spray-to-droplet converter attachment, a cross wall, and a spray delivery tube. The converter attachment is a tubular wall with a passageway between its front and rear ends. The cross wall is disposed in the passageway, spaced from the tubular wall front and rear ends, and extends in a transverse relationship to, and connected with, the tubular wall to define an obstruction in a path of liquid travel through the passageway from the rear end to the front end such that liquid spray impacts the obstruction and converts into liquid droplets that are dispensed from the front end. The spray delivery tube has an exit end mated with the tubular wall upstream of the cross wall relative to the path of liquid travel through the passageway.

Aspects of the present disclosure include fluid dispensers configured to administer pharmaceutical agents to a user's eye. The fluid dispensers and systems described herein include mechanisms for protecting a fluid dispensing nozzle or opening from contamination, preventing dehydration of the fluids, and for sterilizing the dispensing components. A fluid dispenser may include a housing configured to receive a fluid cartridge, the fluid cartridge comprising a nozzle. The housing further comprises a shutter coupled to the housing and configured to articulate between a closed position and an open position. The shutter may be configured to obscure the nozzle in the closed position and to expose the nozzle in the open position. The shutter may further include protrusion configured to engage and actuate a nozzle cover of the fluid cartridge when the shutter articulates to the open position.

An ejector device and method of delivering safe, suitable, and repeatable dosages to a subject for topical, oral, nasal, or pulmonary use is disclosed. The ejector device includes a housing, a reservoir disposed within the housing for receiving a volume of fluid, and an ejector mechanism in fluid communication with the reservoir and configured to eject a stream of droplets, the ejector mechanism comprising an ejector plate coupled to a generator plate and a piezoelectric actuator; the piezoelectric actuator being operable to oscillate the ejector plate, and thereby the generator plate, at a frequency and generate a directed stream of droplets.

An eye treatment positions a mask device over first and second eyes. A posterior side of the mask device is proximate to the face and the anterior side is distal from the face. The mask device includes an outer wall extending between the anterior and posterior sides and defining a chamber extending across the first and second eyes. The anterior side includes a first transmission region that allows a photoactivating light for the first eye to be delivered into a first section of the chamber positioned over the first eye. The anterior side includes a second transmission region that allows a photoactivating light for the second eye to be delivered into the second section positioned over the second eye. The system includes at least one gas source storing a gas that is different than ambient air. The system includes a gas delivery system that delivers the gas into the chamber.

An ejector device and method of delivering safe, suitable, and repeatable dosages to a subject for topical, oral, nasal, or pulmonary use is disclosed. The ejector device includes a housing, a reservoir disposed within the housing for receiving a volume of fluid, and an ejector mechanism in fluid communication with the reservoir and configured to eject a stream of droplets, the ejector mechanism comprising an ejector plate coupled to a generator plate and a piezoelectric actuator; the piezoelectric actuator being operable to oscillate the ejector plate, and thereby the generator plate, at a frequency and generate a directed stream of droplets.

An apparatus has a first fluid conduit, a second fluid conduit, a connector member, an first tubular member, a second tubular member, and an inner cannula. The connector member has first and second passageways in which the first and second fluid conduits are positioned, respectively. A portion of the second tubular member is positioned within the lumen of the first tubular member. A proximal portion of the inner cannula is fixedly secured within the lumen of the first tubular member. The inner cannula lumen is in fluid communication with the first and second fluid conduits via the lumen of the first tubular member and the lumen of the second tubular member. The inner cannula may be inserted into the subretinal space of a human eye to deliver a leading bleb of fluid and then deliver a therapeutic agent, without having to withdraw the inner cannula from the subretinal space between the acts of delivering the leading bleb delivering the therapeutic agent.

Systems and methods for medication management are provided. Some embodiments provide for a portable medication management and monitoring system for eye drop instillation in ocular chronic conditions. At least one embodiment includes a device having one or more of the following elements: (a) a jacket that goes around an eye drop bottle; (b) tactile sensors to detect the user's fingers and generate data to activate the system; (c) motion sensors to detect the motion of the medication bottle when it is grabbed and moved by the user; (d) a wireless communication module to send and receive data to a computer and portable communication devices; and/or (e) a compartment for holding the electronic components.

The present invention provides methods and devices for delivering an active agent into the eye of a subject. In one aspect, for example, the present invention provides an ocular drug delivery device including a housing configured to couple to the eye of the subject and a corneal seal coupled to the housing and positioned in the housing to encircle the cornea during use to form a corneal region, where the housing extends outward from the corneal seal to form a scleral region, and where the scleral region being positioned over the eye's sclera during use. The device further includes an active agent reservoir coupled to the housing and positioned to release active agent into the scleral region and a pressure regulator coupled to the housing that is operable to introduce negative pressure between the housing and the eye. Thus the corneal seal is operable to fluidically isolate the corneal region from the scleral region in response to the negative pressure.