A dispensing device, comprising: a piston-cylinder assembly, the assembly comprising an outlet in fluid communication with a one-way valve and an inlet in fluidic communication with a valve assembly; the one-way valve configured to dispense a liquid from a medicament container, the valve assembly fluidically coupled to the one-way valve, the valve assembly having at least one cannula and at least one flow control member; the piston configured to draw an amount of fluid through the valve assembly and inlet into the cylinder, and to expel the amount of liquid through the one-way valve; and an actuator assembly coupled to and biasing the piston with stored energy.

This invention relates to a Nanostructured Lipid Carrier (NLC) particle comprising a therapeutic agent encapsulated therein for ocular delivery of the therapeutic agent, wherein the Nanostructured Lipid Carrier comprises: (i) a solid outer shell comprising a solid lipid, and (ii) a liquid core comprising a liquid lipid; and wherein the core comprises the therapeutic agent. Compositions of the NLC particles, use of the NLC particles, methods of treatment or prevention of an eye disorder and an eye drop dispenser are also provided.

System and methods for injection into a cavity are provided. In some embodiments, an injection system includes an injection assembly comprising a syringe barrel defining a lumen between proximal and distal ends and a second sealing element moveably disposed within the lumen to dispense an injection agent from an injection chamber defined in the syringe barrel. A puncture element delivers the injection agent into a space in a tissue. The tissue is less permeable to the injection agent than the space. The injection system also includes a support platform to support the injection assembly and anchor it relative to a site of injection, a drive assembly to operate the injection assembly, one or more sensors to monitor one or more forces on the injection assembly, and a controller in communication with the one or more sensors to receive information about the one or more forces on the injection system.

Medical devices and methods of use thereof are described. The device may include a body having a housing that defines a lumen, a piston within the housing, and an actuator operably coupled to the piston, wherein the piston is movable along the lumen by operating the actuator. The device also may include a cartridge insertable into the body and/or a flexible fitting configured for direct application to an eye of a subject.

A wearable device includes: a main frame configured to be mounted on a user's body; an image display module on the main frame and configured to display an image; a lens frame on an image display surface of the image display module, the lens frame being configured to refract image display light emitted from the image display module; a multi-channel lens forming an emission path of the image display light refracted by the lens frame for each of a plurality of channels; and an eyeball protection module on the main frame and configured to spray air, moisture, or a tear solution to the user's left and right eyes.

A dry eye treatment device includes a substrate. At least one reservoir is formed in the substrate. A histamine agonist is disposed within the at least one reservoir. The histamine agonist is configured to be delivered to at least one histamine receptor on or adjacent to an eye.

An implant for insertion through a punctum and into a canalicular lumen of a patient. The implant includes a matrix of material, a therapeutic agent dispersed in the matrix of material, a sheath disposed over a portion of the matrix of material and configured to inhibit the therapeutic agent from being released from the matrix of material into the canalicular lumen and to allow the therapeutic agent to be released from a surface of the matrix of material to a tear film, and a retention structure configured to retain the implant within the canalicular lumen.

An eyedropper (2, 102) having improved stability is provided for administering a volume of liquid onto the surface of an eye (57). The eyedropper (2, 102) includes a body (4, 104) having a reservoir body (18, 118), a first foot (14, 114), a second foot (16, 116), and a nozzle (26, 126). The nozzle (26, 126) is in fluid communication with the internal cavity (24, 124) of the reservoir body (18, 118) and projecting from an outer surface (20, 120) of the reservoir body (18, 118) between the first and second feet (14, 16, 114, 116). The first and second feet (14, 16, 114, 116) are separated by a distance that is at least equal to the height of the eyedropper (2, 102). In preferred embodiments, the distance between the first and second feet (14, 16, 114, 116) is greater than the height of the reservoir body (18, 118).

Disclosed is an accommodating intraocular lens device for treatment of an eye including a stabilization haptic (120) configured to be positioned within a region of an eye and a lens body having a sealed chamber containing a fixed volume of optical fluid. The lens body includes a shape changing membrane (145) configured to outwardly bow in a region surrounding the optical axis of the eye; a shape deformation membrane configured to undergo displacement relative to the first shape changing membrane; and a static element (150). An inner surface of the shape changing membrane, an inner surface of the shape deformation membrane and an inner surface of the static element collectively form the sealed chamber. The lens device also includes a force translation arm (115) having a first end configured to contact an outer surface of the shape deformation membrane of the lens body and a second end configured to engage a ciliary structure of the eye. The force translation arm is configured to move relative to the lens body upon movement of the ciliary structure.

Systems and methods are provided for image-guided delivery of therapeutics to an eye. An optical coherence tomography (OCT) imager is configured to produce at least one OCT image of the eye. A therapeutic delivery system is configured to deliver a therapeutic to the eye through a distal end of a delivery mechanism. A system control is configured to determine a position of the distal end of the delivery mechanism and control the therapeutic delivery system according to at least the determined position.