An ejector device and method of delivering safe, suitable, and repeatable dosages to a subject for topical, oral, nasal, or pulmonary use is disclosed. The ejector device includes a housing, a reservoir disposed within the housing for receiving a volume of fluid, and an ejector mechanism in fluid communication with the reservoir and configured to eject a stream of droplets, the ejector mechanism comprising an ejector plate coupled to a generator plate and a piezoelectric actuator; the piezoelectric actuator being operable to oscillate the ejector plate, and thereby the generator plate, at a frequency and generate a directed stream of droplets.

Method and apparatus for protecting and treating wounds are provided. A housing is adapted to be adhesively secured over the wound of an injured or infected person. The housing has an opening for access to the wound, and is further provided with inlet and outlet ports for the application of therapeutic materials. There is particularly provided a program for a closed looped system for such wound care. Additionally, the invention provides for a protective and treating cover for the eye, which can be either opaque or translucent. Additionally, a mechanism for accurately depositing eye drops without risking injury to the eye is also provided.

An apparatus includes a body, a needle, a catheter, and an actuator assembly. The needle extends distally from the body. The needle has an inner wall defining a needle lumen. The needle lumen is in fluid communication with a fluid port of the body. The catheter is slidably disposed in the needle lumen. The catheter has a catheter lumen. The first actuator assembly is configured to translate the catheter within and relative to the needle. The apparatus may also include an actuator assembly that is configured to rotate the needle relative to the body. The apparatus may be used to first deliver a leading bleb of fluid to the subretinal space in a patient's eye via the needle. The apparatus may then be used to deliver a therapeutic agent to the subretinal space in the patient's eye via the catheter.

Injection devices for delivering pharmaceutical compositions into the eye are described. Some devices include a resistance component for controllably deploying an injection needle through the eye wall. The resistance component may be disposed on a removable injector attachment or on a portion of the injection device housing. Other devices may include a filter for the removal of air, infectious agents, and/or other particulate matter from the composition before the composition is injected into the eye. Related methods and systems comprising the devices are also described.

A device for inducing production of tears may include a body extending from a proximal end to a distal end. The body may be configured for insertion through a puncta of a subject. The device also may include a stimulus delivery mechanism positioned between the proximal end and the distal end and an induction coil operably coupled to the stimulus delivery mechanism. Further, the device may include an external controller wirelessly coupled to the induction coil for inductively transferring energy to the induction coil.

A device for inducing production of tears may include a body extending from a proximal end to a distal end. The body may be configured for insertion through a puncta of a subject. The device also may include a stimulus delivery mechanism positioned between the proximal end and the distal end and an induction coil operably coupled to the stimulus delivery mechanism. Further, the device may include an external controller wirelessly coupled to the induction coil for inductively transferring energy to the induction coil.

Medical devices and methods of use thereof are described. The device may include a body having a housing that defines a lumen, a piston within the housing, and an actuator operably coupled to the piston, wherein the piston is movable along the lumen by operating the actuator. The device also may include a cartridge insertable into the body and/or a flexible fitting configured for direct application to an eye of a subject.

Methods, systems, devices, and apparatuses for dispensing a predetermined amount of fluid to a surface of an eye. A dispensing system includes one or more bottle assemblies each including a bottle enclosure and a cup-shaped member coupled to the bottle enclosure to form a hermetically sealed fluid compartment within the bottle enclosure for holding the fluid. The one or more bottle assemblies further include a dispensing mechanism coupled to the cup-shaped member and configured to dispense the predetermined amount of the fluid. The dispensing system further includes a reusable electric dispensing actuator configured to removably couple to a bottle assembly of the one or more bottle assemblies by sliding into the cup-shaped member and to activate the dispensing mechanism to pull the fluid from the hermetically sealed fluid compartment and dispense the fluid through a dispensing tip.

A method, system, and device for magnetically pushing agents into an eye. The agents are magnetic or magnetizable or magnetically responsive

A device includes an image capture device directed towards a user's eye and a dispensing mechanism configured to receive an apparatus containing fluid. The image capture device is coupled to a controller that processes images of the user's eye captured by the image capture device to determine when the user's eye has been open for at least a threshold amount of time. An orientation sensor included in the device determines an orientation relative to vertical of the device. When the controller determines that the user's eye has been open for at least a threshold amount of time and that the device has an orientation within a specific range, the dispensing mechanism applies force to the apparatus storing fluid to dispense fluid. One or more sensors in the device detect when fluid has been dispensed.