A control device for controlling and/or regulating an injection flow rate, when injecting a fluid at an injection site between two tissue layers of the human eye with an injection flow rate that increases with time, is described, which comprises a controlling or regulating unit configured to control the injection flow rate in such a way that the injection flow rate increases during the injection for at least 30% of the injection time or during the injection of at least 30% of the injection volume.

A cannula assembly having a retractable cannula tip for use in ophthalmic surgical procedures is disclosed. The apparatus may include a housing having a valve bay disposed between its proximal and distal ends, and a cannula assembly, including an inner and outer tube, that extends from the distal end of the housing. The inner tube may include an elongated portion with a cannula tip at its distal end. The apparatus may further include a valve disposed in the valve bay of the housing. The valve may comprise a valve tubular for adjusting flow through the inner tube, and an actuator for moving the cannula tip from an extended position to a retracted position in the outer tube. The valve tubular may provide a biasing force to the inner tube in the retracted position to move the inner tube back to the extended position upon release of the actuator.

Surgical implants and methods to improve, support, or help to preserve vision by altering the axial length or curvature of an eye are provided. Staphyloma supporting devices or implants can be of unitary construction from a single base material such as titanium alloy and can have a macular indenter plate wider than the implant body and an anchor structure wider than the macular indenter plate. A compound concavity scleral contact surface can approximate the outer surface of the eye with an anterior radius of curvature and can restore macular shape and axial length with a second posterior radius of curvature that can be less than the anterior radius of curvature.

Surgical implants and methods to improve, support, or help to preserve vision by altering the axial length or curvature of an eye are provided. Staphyloma supporting devices or implants can be of unitary construction from a single base material such as titanium alloy and can have a macular indenter plate wider than the implant body and an anchor structure wider than the macular indenter plate. A compound concavity scleral contact surface can approximate the outer surface of the eye with an anterior radius of curvature and can restore macular shape and axial length with a second posterior radius of curvature that can be less than the anterior radius of curvature.

A device for applying a bubble of a substance to a tissue surface, the device comprising a cannula, a distal tip at the distal end portion of the cannula, the distal tip having a bubble support surface and an exit port extending through the bubble support surface, an expansion fluid passageway extending through the cannula to the exit port, a source of an expansion fluid and an actuator therefor. In some arrangements, the distal tip can be configured to support a layer of the substance thereon over the distal port and the device can be configured such that the advancement of the expansion fluid from the fluid source through the exit port causes at least one bubble of the substance to form on the distal tip, wherein the at least a portion of the bubble can be transferred to the tissue surface to treat a defect on the tissue surface.

Several embodiments disclosed herein relate to compositions and methods for treating or repairing damage to ocular tissue. In particular, several embodiments relate to patches that interact, e.g., by way of an adhesive, with damaged retinal tissue to repair or mend a hole, tear or detachment of the retina from underlying ocular tissue. Still additional embodiments relate to self-assembling patches.

Surgical implants and methods to improve, support, or help to preserve vision by altering the axial length or curvature of an eye are provided. Staphyloma supporting devices or implants can be of unitary construction from a single base material such as titanium alloy and can have a macular indenter plate wider than the implant body and an anchor structure wider than the macular indenter plate. A compound concavity scleral contact surface can approximate the outer surface of the eye with an anterior radius of curvature and can restore macular shape and axial length with a second posterior radius of curvature that can be less than the anterior radius of curvature.

Devices, systems and methods for applying a bioadhesive substance to an internal surface of the eye, such as the retina, can include an outer sleeve having a proximal end, a distal end, a passageway extending along a length of the elongate body and an opening at the distal end of the elongate body, an applicator tip including an elongate body having a proximal end and a distal end, an applicator portion coupled with the distal end of the elongate body, and a substance supply lumen extending along a length of the device through which a bioadhesive substance can pass so that the bioadhesive substance can be applied to at least the applicator portion of the applicator tip. Some embodiments of the device can also have a source of the bioadhesive substance in fluid communication with at least the substance supply lumen.

Devices, systems and methods for applying a bioadhesive substance to an internal surface of the eye, such as the retina, can include an outer sleeve having a proximal end, a distal end, a passageway extending along a length of the elongate body and an opening at the distal end of the elongate body, an applicator tip including an elongate body having a proximal end and a distal end, an applicator portion coupled with the distal end of the elongate body, and a substance supply lumen extending along a length of the device through which a bioadhesive substance can pass so that the bioadhesive substance can be applied to at least the applicator portion of the applicator tip. Some embodiments of the device can also have a source of the bioadhesive substance in fluid communication with at least the substance supply lumen.

A handheld implantation device for implantation of a retinal tissue implant at an implantation site. The handheld implantation device includes a handheld implantation tool having a leading implantation tool end and a trailing implantation tool end, an implant holder for peripherally holding a retinal tissue implant including an uppermost viable retinal tissue and a lowermost basement membrane and a clinician-operated attachment arrangement for initial attaching the implant holder at the leading implantation tool end and subsequent selected detaching the implant holder therefrom at the implantation site for implantation of the implant holder together with the retinal tissue implant thereat.