Methods of delivering agents to structures within the eye are provided.

Disclosed herein are surgical instruments used in ophthalmic surgical procedures and associated methods. Particular embodiments relate to a cannula assembly having a cannula tip that is retractable. The cannula assembly may comprise a cannula hub. The cannula assembly may further comprise an outer tube that extends from a distal end the cannula hub. The cannula assembly may further comprise an inner tube that extends from the distal end of the cannula hub and is disposed in the outer tube, wherein the inner tube has a cannula tip that extends from the outer tube and is retractable into the outer tube.

A cannula assembly having a retractable cannula tip for use in ophthalmic surgical procedures is disclosed. The apparatus may include a housing having a valve bay disposed between its proximal and distal ends, and a cannula assembly, including an inner and outer tube, that extends from the distal end of the housing. The inner tube may include an elongated portion with a cannula tip at its distal end. The apparatus may further include a valve disposed in the valve bay of the housing. The valve may comprise a valve tubular for adjusting flow through the inner tube, and an actuator for moving the cannula tip from an extended position to a retracted position in the outer tube. The valve tubular may provide a biasing force to the inner tube in the retracted position to move the inner tube back to the extended position upon release of the actuator.

A unique vitrectomy probe with an interfacing component for attenuating vibrations during a vitrectomy procedure. The component may be of elastomeric construction tailored to attenuating the vibrations. Additionally, the component may strategically reside at an interface between the housing that accommodates moving parts of the probe and an ergonomic shell meant for resting at purlicue a surgeon's hand. In this way, vibrations are largely attenuated before reaching the shell and distracting the surgeon. Additionally, the shell, housing and interface are architecturally constructed for user-friendly shell removal for surgeons wishing to perform vitrectomy procedures in absence of the shell.

Particular embodiments disclosed herein provide a retina massage and smoothing device. In certain embodiments, the device comprises a tip configured to be used for manipulating a surface of a retina inside an eye, and a shaft coupled to the tip, the shaft having a proximal end configured to be coupled to a handle, wherein the shaft is further configured to be at least partially housed by an outer tube of the handle.

Several embodiments disclosed herein relate to compositions and methods for treating or repairing damage to ocular tissue. In particular, several embodiments relate to patches that interact, e.g., by way of an adhesive, with damaged retinal tissue to repair or mend a hole, tear or detachment of the retina from underlying ocular tissue. Still additional embodiments relate to self-assembling patches.

A method of treating a detachment of a retina of an eye, the method including the steps of injecting a substance into a vitreous cavity of the eye, the substance slowing flow of fluid through the vitreous cavity into a subretinal space to reduce a rate of accumulation of a subretinal fluid in the subretinal space to below a rate of removal of the subretinal fluid from the subretinal space by retinal pigment epithelium; and permitting the retinal pigment epithelium to reattach the retina. The invention also includes devices for practicing the method.

Certain aspects of the present disclosure provide an apparatus and method of using a multifunctional device to cut/tab a graft from a donor region of an eye. The apparatus includes a multifunctional device for ophthalmic surgery, having an insertion sleeve comprising an inner surface defining a compartment, a flat wire contained within the compartment folded to form a loop, wherein the flat wire comprises a sharp edge (continuous or tabbed) operable for cutting retinal tissue, and wherein the loop is positioned at a distal end of the insertion sleeve, and a handpiece coupled to the insertion tube and configured to adjust a size of the loop.

A handheld implantation device for implantation of a retinal tissue implant at an implantation site. The handheld implantation device includes a handheld implantation tool having a leading implantation tool end and a trailing implantation tool end, an implant holder for peripherally holding a retinal tissue implant including an uppermost viable retinal tissue and a lowermost basement membrane and a clinician-operated attachment arrangement for initial attaching the implant holder at the leading implantation tool end and subsequent selected detaching the implant holder therefrom at the implantation site for implantation of the implant holder together with the retinal tissue implant thereat.

Provided herein are in vivo gelling ophthalmic pre-formulations forming a biocompatible retinal patch comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and optionally a therapeutic agent and/or viscosity enhancer. In some embodiments, the retinal patch at least partially adheres to the site of a retinal tear. Also provided herein are methods of treating retinal detachment by delivering an in vivo gelling ophthalmic pre-formulation to the site of a retinal tear in human eye, wherein the in vivo gelling ophthalmic pre-formulation forms a retinal patch.