The present invention relates to a nasolacrimal duct insertion member comprising a shape memory polymer for treatment of nasolacrimal duct obstruction/stenosis, wherein the shape memory polymer comprises a crosslinkable functional group, such that the nasolacrimal duct insertion member has a melting point suitable for implantation into a living body.

An eyelid manipulation device includes a rigid contact portion dimensioned to be insinuated between an eyelid and a globe, the contact portion having an upwardly-facing surface opposite a downwardly-facing surface, each of the surfaces extending between a distal side and a proximal side of the contact portion; and a rigid stem integral with and extending upwardly from the proximal side of the contact portion. In embodiments, the stem is connectable to a handle. In other embodiments, the stem is elongated, thereby serving as a handle. The eyelid manipulation device may be used during treatment of Meibomian glands or otherwise during treatment of dry eye symptoms.

Devices and method for treating aqueous collector channels or tissue(s) associated with aqueous collector channels to improve or enhance outflow of aqueous humor from an eye thereby reducing intraocular pressure in the eye.

Embodiments of the present invention provide methods for performing dacryocystorhinostomy and an apparatus for performing dacryocystorhinostomy (DCR), the apparatus comprising a dacryocystorhinostomy (DCR) tool, which includes a perforating shaft having a distal perforating-shaft perforating tip configured to form a bypass between a lacrimal sac and a nasal cavity through a lateral side of the lacrimal sac, a lacrimal bone, and nasal mucosa and a DCR guide, which includes a nasal guide component, which is configured to be inserted into the nasal cavity and has a nasal-guide channel having a proximal opening and an at least partially laterally facing distal opening, and a lacrimal guide component, which is shaped so as to define a lacrimal-guide channel that is configured to orient the distal perforating-shaft perforating tip with respect to the DCR guide during advancing of the distal perforating-shaft perforating tip through a lacrimal passageway and into the lacrimal sac, until the distal perforating-shaft perforating tip at least crosses the laterally facing distal opening of the nasal guide component, and wherein the DCR guide is configured to constrain the laterally facing distal opening of the nasal guide component to fall in a path of advancement of the distal perforating-shaft perforating tip.

A solid matrix sustained release ophthalmic formulation for topical delivery of a solid ophthalmic drug to the eye, medical devices, drug cores, drug inserts and drug delivery systems comprising the formulation, methods of manufacturing the formulation, medical devices and their methods thereof for delivering the ophthalmic drug for a treatment period provided herein. The formulation disclosed herein is an admixture of an ophthalmic drug, and a combination of a hydrophobic polymer, a hydrophilic polymer and a surfactant, wherein the drug is eluted daily over an extended period of time at therapeutic dose of drug.

A handheld device for applying mechanical vibration to a body portion of an individual to treat a condition of the individual, includes: a housing; a cantilever beam having a first portion accommodated in the housing, and a second portion that is moveable relative to the housing, wherein the second portion is configured to apply the mechanical vibration to the body portion; and a motor in the housing, the motor configured to oscillate the second portion of the cantilever beam at an oscillation frequency.

Certain aspects are directed to an ophthalmic specialty instrument configured to allow patients to treat MGD and other dry eye conditions themselves which is easy to operate and more effective. The ophthalmic specialty instrument comprises a main body of two arms with a distal end and a proximal end; wherein the two arms are pivotably coupled to a common connection point at the proximal end and a pair of angled and slightly wedged pressure plates are attached to the distal end of the two arms; wherein an exfoliating member is also attached to the proximal end; and wherein the pressure plates are angled downwardly and outwardly from the longitudinal planes of the arms and have gentle radius of curvature that match the curvature of eyelids to facilitate a substantially 90° approaching angle to the eyelid margin as opposed to making contact with the eyelids tangentially.

Lacrimal implants and related methods providing secure, wedgable retention within a lacrimal punctum and associated canaliculus of an eye are disclosed. The lacrimal implants can comprise an implant body configured for at least partial insertion through the lacrimal punctum and into the canaliculus. The implant body can include first and second portions, and can extend from a proximal end of the first portion defining a longitudinal proximal axis to a distal end of the second portion defining a longitudinal distal axis. The implant body can be configured such that, when implanted using an integral dilator, an angled intersection exists between the proximal and distal axes. In this way, at least a portion of the implant body can be biased against at least a portion of the lacrimal canaliculus located at or more distal to a canalicular curvature, thereby retaining an implanted position of the lacrimal implant using anatomical structures.

Provided herein are methods and devices for grasping and/or tearing trabecular meshwork of an eye of a subject. The devices may include a shaft and a tissue grabber coupled to the shaft. The tissue grabber may include an elongate lower foot configured to be inserted into Schlemm's canal, and a groove configured to grasp a portion of the trabecular meshwork. The methods may include: advancing a tissue grabber to Schlemm's canal of the eye, wherein the tissue gripper comprises a lower foot and a tissue grabbing region; advancing a tip of the lower foot through the trabecular meshwork and into Schlemm's canal; and advancing the lower foot within and relative to Schlemm's canal, wherein as the lower foot is advanced, a portion of the trabecular enters the tissue gripping region, is torn from surrounding tissue, and is collected within the tissue gripping region.

A dacryocystorhinostomy (DCR) tool (10) includes a perforating shaft (30) having a distal perforating tip (32) configured to form a bypass between a lacrimal sac and a nasal cavity through a lateral side of the lacrimal sac, a lacrimal bone, and nasal mucosa. A DCR guide (20) includes a nasal guide component (40) configured to be inserted into the nasal cavity and having a distal guide tip (42); and a lacrimal guide component (50) shaped so as to define a guide channel (52) that orients the DCR guide (20) with respect to the distal perforating tip (32) during advancing of the distal perforating tip (32) through a lacrimal passageway and into the lacrimal sac, until contact of the distal perforating tip (32) with the distal guide tip (42) blocks further advancing of the distal perforating tip (32). The DCR guide (20) constrains the distal guide tip (42) to fall in a path of advancement of the distal perforating tip (32). Other embodiments are also described.