A microsurgical instrument includes a cannula head rotationally coupled to a handpiece. A cannula head connector at a distal end of the handpiece rotationally couples to a handpiece connector at a proximal end of the cannula head. The cannula head connector and handpiece connector rotate coaxially about a longitudinal center axis passing through a cannula extending from the cannula head, providing an adjustable cannula angle between the cannula head and handpiece. The cannula head is securely retained to the handpiece without slippage changing the cannula angle, and the cannula angle is easily changed to a new value by deliberate rotation of the cannula head.

Methods, systems, and compositions for maintaining functioning drainage blebs to reduce intraocular pressure (IOP) of an eye being treated for glaucoma. The methods, systems, and compositions feature the combination of a minimally invasive glaucoma surgery (MIGS) implant or procedure and the application of beta radiation to the bleb. The beta radiation can function to inhibit or reduce the inflammation and/or fibrogenesis that typically occurs after insertion of a MIGS implant and leads to bleb failure. By reducing inflammation and/or fibrogenesis, the MIGS implant and the blebs can remain functioning appropriately.

An ablation device for the treatment of an eye to lower intraocular pressure including a handle; and an array of rods projecting from a distal end region of the handle and electrically-connected to an energy delivery generator. Each rod of the array of rods is configured to create a cavity in a surface of the eye via ab externo tissue ablation to enhance drainage of aqueous humor from the eye. Related devices, systems, and methods are provided.

A method for a minimally invasive, cell-selective laser therapy on the eye. The method, based on a short-pulse laser system, allows for different selective types of therapy on the eye. The method is based on a frequency-doubled, continuously working solid-state laser including a pump source and a control unit. The control unit regulates the pump source such that the solid-state laser emits individual pulses with pulse lengths ranging from 50 ns to continuous, wherein pulse lengths ranging from 50 ns to 50 μs are provided for selective therapies and pulse lengths ranging from 50 μs to continuous are provided for coagulative or stimulating therapies, in particular in the range from 1 ms to 500 ms. The proposed method enables a selective treatment of melanin-containing cells in the different areas of the eye via the targeted control of the pump source.

A device and method for cutting or ablating tissue in a human or veterinary patient includes an elongate probe having a distal end, a tissue cutting or ablating apparatus located adjacent within the distal end, and a tissue protector extending from the distal end. The protector generally has a first side and a second side and the tissue cutting or ablating apparatus is located adjacent to the first side thereof. The distal end is structured to be advanceable into tissue or otherwise placed and positioned within the patient's body such that tissue adjacent to the first side of the protector is cut away or ablated by the tissue cutting or ablation apparatus while tissue that is adjacent to the second side of the protector is not substantially damaged by the tissue cutting or ablating apparatus.

Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allow for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.

A collagen cross-linking system for treating a tissue of a patient, the system including: a catheter having a flexible shaft and a conforming member, the flexible shaft having distal and proximal ends, a shaft body extending between the distal end and the proximal end, the shaft body defining a lumen, the conforming member being fixed to the catheter shaft near the distal end, the conforming member comprising a membrane defining a cavity in fluid communication with the lumen; a fluid source coupled to the proximal end of the catheter, the flexible shaft of the catheter being configured so that a flow of photosensitizing fluid provided by the fluid source flows through the membrane of the conforming member; and a light source coupled to the proximal end of the catheter, the catheter being configured so that photo-activating light generated by the light source passes through the membrane of the conforming member.

A phacoemulsification handpiece for ocular surgery includes a housing including a grip for holding the phacoemulsification handpiece, a needle extending from the housing for removing ocular material from an eye, and a horn connected with the needle. The phacoemulsification handpiece also includes a driving circuit configured to vibrate the horn according to a multi-harmonic driving signal, to generate non-sinusoidal ultrasonic motion of a tip of the needle.

A method for removing soft tissue from a target tissue of the eye to enable drainage of excessive fluid, the method comprising: providing a device comprising a soft-tissue cutting tool, the cutting tool comprising an elongated proximal part attached to a proximal handle for gripping the device, a distal part having an open distal end and a distal cutting edge configured to attach to and cut the soft tissue, and a cavity extending inside the cutting tool to receive the cut soft tissue; positioning the device at a first point with respect to the eye; advancing the device along an axis until contacting said target tissue; distally progressing and rotating at least the distal part of the cutting tool into the target tissue to cut and remove the soft tissue by the distal part of the cutting tool, and storing the removed soft tissue in the cavity, thereby creating a channel of a predetermined geometry across the target tissue layer; retracting at least the distal part proximally out of the target tissue; and withdrawing the device out of the body, thereby leaving the created channel allowing the drainage of the excessive fluid.

An elongate electrode is configured to flex and generate plasma to incise tissue. An electrical energy source operatively coupled to the electrode is configured to provide electrical energy to the electrode to generate the plasma. A tensioning element is operatively coupled to the elongate electrode. The tensioning element can be configured to provide tension to the elongate electrode to allow the elongate electrode to flex in response to the elongate electrode engaging the tissue and generating the plasma. The tensioning element operatively coupled to the flexible elongate electrode may allow for the use of a small diameter electrode, such as a 5 μm to 20 μm diameter electrode, which can allow narrow incisions to be formed with decreased tissue damage. In some embodiments, the tensioning of the electrode allows the electrode to more accurately incise tissue by decreasing variations in the position of the electrode along the incision path.