The present invention provides a keratoprosthesis assembly comprising a central optical core; and a peripheral skirt comprising at least one porous biocompatible layer and methods of using it in keratoprosthesis procedures.

A method for treating hyperopia or presbyopia in a patient, the method comprising making a cut deep in the patient's cornea to create a two-dimensional slit adjacent to and generally parallel to an anterior surface of the cornea and injecting a liquid or semi-solid transparent filler material into the deep cut in an amount sufficient to flatten the posterior surface of the cornea to increase the refractive power of the cornea by a predetermined correction of up to about 5 diopters due to the physical flattening of the posterior surface of the cornea, wherein the transparent filler material comprises a refractive index of about 1.3 to about 1.6, and forms a corneal implant with a lenticular shape within the cornea.

A method for treating hyperopia or presbyopia in a patient, the method comprising making a cut deep in the patient's cornea to create a two-dimensional slit adjacent to and generally parallel to an anterior surface of the cornea and injecting a liquid or semi-solid transparent filler material into the deep cut in an amount sufficient to flatten the posterior surface of the cornea to increase the refractive power of the cornea by a predetermined correction of up to about 5 diopters due to the physical flattening of the posterior surface of the cornea, wherein the transparent filler material comprises a refractive index of about 1.3 to about 1.6, and forms a corneal implant with a lenticular shape within the cornea.

A contact lens for corrective corneal crosslinking has a lens part and reservoir part. The lens part is constituted of a UV transmitting material, and provided, on a side thereof being in contact with the cornea of a patient's eyeball, with a pressing region configured to project in a convexly curved shape at a position for pressing the corneal dome center, and a relief region including an annular concave part whose cross section has a concavely circular arc shape that surrounds the pressing region's outer circumference. The reservoir part is disposed seamlessly and integrally therewith on the lens' outer side in a thickness direction in the pressing region, the reservoir part is provided with a communication hole for communication between the inside of the reservoir part and the pressing region, and a working electrode that has the same polarity as that of the riboflavin solution in the reservoir part.

A contact lens for corrective corneal crosslinking has a lens part and reservoir part. The lens part is constituted of a UV transmitting material, and provided, on a side thereof being in contact with the cornea of a patient's eyeball, with a pressing region configured to project in a convexly curved shape at a position for pressing the corneal dome center, and a relief region including an annular concave part whose cross section has a concavely circular arc shape that surrounds the pressing region's outer circumference. The reservoir part is disposed seamlessly and integrally therewith on the lens' outer side in a thickness direction in the pressing region, the reservoir part is provided with a communication hole for communication between the inside of the reservoir part and the pressing region, and a working electrode that has the same polarity as that of the riboflavin solution in the reservoir part.

Postoperative lens position is predicted on the basis of known measured values, such as the corneal thickness, the depth of the anterior chamber, the eye length, and the distances of the capsular bag equator and/or of the lens haptic from the anterior surface of the lens. In addition, the calculation also takes into account the attitude of the intraocular lens, for which purpose additional parameters of the pseudophakic eye are used that have not previously been taken into consideration. The proposed method is suitable for a more exact prediction of the strength and nature of an intraocular lens to be implanted in a pseudophakic eye in the context of cataract surgery or of a refractive intervention. The method is based on the use of suitable calculation methods, e.g. geometric optical formulae, or of ray tracing.

Postoperative lens position is predicted on the basis of known measured values, such as the corneal thickness, the depth of the anterior chamber, the eye length, and the distances of the capsular bag equator and/or of the lens haptic from the anterior surface of the lens. In addition, the calculation also takes into account the attitude of the intraocular lens, for which purpose additional parameters of the pseudophakic eye are used that have not previously been taken into consideration. The proposed method is suitable for a more exact prediction of the strength and nature of an intraocular lens to be implanted in a pseudophakic eye in the context of cataract surgery or of a refractive intervention. The method is based on the use of suitable calculation methods, e.g. geometric optical formulae, or of ray tracing.

Various membrane delamination devices for removing proliferative membranes from underling tissues are disclosed herein. In some implementations, the delamination device may include a first shearing part and a second shearing part. One of the first shearing part and the second shearing part may be moveable relative to the other of the first shearing part and the second shearing part. One or more of the shearing parts may include a plurality of teeth formed at a leading edge thereof. A shearing action produced by operation of the shearing parts may be used to sever fibers joining proliferative membranes from an underlying tissue.

Various membrane delamination devices for removing proliferative membranes from underling tissues are disclosed herein. In some implementations, the delamination device may include a first shearing part and a second shearing part. One of the first shearing part and the second shearing part may be moveable relative to the other of the first shearing part and the second shearing part. One or more of the shearing parts may include a plurality of teeth formed at a leading edge thereof. A shearing action produced by operation of the shearing parts may be used to sever fibers joining proliferative membranes from an underlying tissue.

The present invention provides a keratoprosthesis assembly comprising a central optical core; and a peripheral skirt comprising at least one porous biocompatible layer and methods of using it in keratoprosthesis procedures.