The present disclosure relates generally to dry inks for use in marking the eye prior to surgery and methods of applying the same to eye marking devices. Such inks can include various accepted inks for use on the eye that can be applied to a marking device using relatively fast-evaporating solvents. In this manner, the remaining ink composition can be precisely placed on the eye marking device, and desirably transfer to the marking surface of the eye without dissolving on the journey through the various membranes above the marking surface. Application methods may include use of charged ink particles that may be advantageously manipulated using magnetic fields to even more precisely place the dry ink on a marking device.

A surgical instrument for marking spots at locations on the scleral limbal surface of a human eye. The instrument includes an elongated handle dimension to be handheld. A first elongated pointer extends substantially axially outwardly from one end of the handle. This pointer has a pointed free end which, when pressed against the scleral limbal surface, creates a depression in the scleral surface having a first area. A second elongated pointer also extends substantially axially outwardly from the end of the handle. The second pointer has a blunt free end which, when pressed against the scleral limbal surface, creates a depression in the scleral surface having a second area which is several times in magnitude the area of the first area.

The shaped corneal/other tissue/bioengineered material trephines can create single or combination of shaped cuts and sections in cornea, sclera or any other tissue or bioengineered material of desired shapes, thickness, width, depth, radius, sizes/dimensions, measurements and configurations. It can create certain patterned or shaped cuts in tissue including but not limited to cornea and sclera/bioengineered material without using the femtosecond laser, especially in the case of cornea where at present the femtosecond laser is required for this purpose. A manual or motorized trephine allows creating cuts in different shapes, thicknesses, width, depth, radius, sizes/dimensions, configurations and measurements with single/multiple or combination of cuts. These configurable cuts give the advantage of creating shaped incisions/sections in the body of a subject as well as give the ability to create donor and recipient sections of cornea, sclera or any other tissue or bioengineered material of specific shapes and dimensions. It therefore gives the ability to create these shaped cuts and sections of tissue without the need for a femtosecond laser and also ability to cut through tissue that is not necessarily transparent.

The shaped corneal/other tissue/bioengineered material trephines can create single or combination of shaped cuts and sections in cornea, sclera or any other tissue or bioengineered material of desired shapes, thickness, width, depth, radius, sizes/dimensions, measurements and configurations. It can create certain patterned or shaped cuts in tissue including but not limited to cornea and sclera/bioengineered material without using the femtosecond laser, especially in the case of cornea where at present the femtosecond laser is required for this purpose. A manual or motorized trephine allows creating cuts in different shapes, thicknesses, width, depth, radius, sizes/dimensions, configurations and measurements with single/multiple or combination of cuts. These configurable cuts give the advantage of creating shaped incisions/sections in the body of a subject as well as give the ability to create donor and recipient sections of cornea, sclera or any other tissue or bioengineered material of specific shapes and dimensions. It therefore gives the ability to create these shaped cuts and sections of tissue without the need for a femtosecond laser and also ability to cut through tissue that is not necessarily transparent.

A system for incising tissue with a plasma comprises an elongate electrode configured to incise the tissue along a tissue incision profile and a tissue contact element configured to shape the tissue, which comprises one or more of a channel or a protrusion to form one or more of a corresponding protrusion or indentation in a tissue surface while the tissue is incised with the electrode along the incision profile. The tissue contact element shapes the tissue sufficiently to allow the tissue to form one or more complimentary features along the incision profile when the tissue relaxes to a free-standing configuration with removal of the tissue contact element. The complementary features may be incised into the tissue to provide increased mechanical stability between the separated tissue regions, such as with nominally interlocking protrusion(s) and indentation(s).

A system for incising tissue with a plasma comprises an elongate electrode configured to incise the tissue along a tissue incision profile and a tissue contact element configured to shape the tissue, which comprises one or more of a channel or a protrusion to form one or more of a corresponding protrusion or indentation in a tissue surface while the tissue is incised with the electrode along the incision profile. The tissue contact element shapes the tissue sufficiently to allow the tissue to form one or more complimentary features along the incision profile when the tissue relaxes to a free-standing configuration with removal of the tissue contact element. The complementary features may be incised into the tissue to provide increased mechanical stability between the separated tissue regions, such as with nominally interlocking protrusion(s) and indentation(s).

A capsulorhexis device is inserted into an incision site of a cornea to make an incision in an anterior capsule surrounding a crystalline lens. The capsulorhexis device includes a loop having elasticity and conductivity; a moving member having one end fixed and coupled to the loop; an insertion guide configured so that, while the incision is being made in the crystalline lens capsule, a front end thereof is inserted into the incision site of the cornea; and a housing having one end coupled to a rear end of the insertion guide, wherein the loop is housed in the housing and, to make the incision in the crystalline lens capsule, slides in the housing together with the moving member to pass through the insertion guide and be deployed into an anterior chamber of the eye.

A device for marking a corneal surface of an eye includes a planar base having a central opening, a marking side, and a non-marking side, a linear marker extending across the central opening, and an outer circumference of the planar base having a wall extending vertically away from the non-marking side.

A microsurgical device and methods of its use can be used for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. A dual-blade device can be used for cutting the trabecular meshwork (TM) in the eye. The device tip provides entry into the Schlemm's canal via its size (i.e., for example, 0.2-0.3 mm width) and configuration where a ramp elevates the TM away from the outer wall of the Schlemm's canal and guides the TM to first and second lateral elements for creating first and second incisions through the TM. The dimensions and configuration of the blade is such that an entire strip of TM is removed without leaving TM leaflets behind and without causing collateral damage to adjacent tissues.

A microsurgical device and methods of its use can be used for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. A device can be used for cutting the trabecular meshwork (TM) in the eye. The device tip provides entry into the Schlemm's canal via its size (i.e., for example, 0.2-0.3 mm width) and configuration where a ramp elevates the TM away from the outer wall of the Schlemm's canal and guides the TM to first and second lateral elements for creating first and second incisions through the TM. The dimensions and configuration of the device is such that an entire strip of TM is removed without leaving TM leaflets behind and without causing collateral damage to adjacent tissues.