Disclosed herein are matrices, compositions and methods of making matrices. The matrix comprises a biomolecule and the matrix is a dried, cross-linked foam. The matrix is not lyophilized. The method comprises foaming the composition, crosslinking the composition and drying the composition. Matrices disclosed herein are useful as wound dressings and treating wounds.

A wound dressing material comprises first and second wound-contact scrims, and an antimicrobial layer disposed therebetween. The wound-contact scrims comprise water-sensitive fibers comprising a copolymer comprising divalent hydroxyethylene monomer units and divalent dihydroxybutylene monomer units. The wound dressing material may be contacted with an exposed surface of a wound. A method of making the wound dressing material is also disclosed.

A surface is covered with microstructures that extend from the surface, and are made of a resilient material that allows the microstructures to bend or articulate. The microstructures are generally columnar and can have fingers on their distal or top end that is opposite the base from which the microstructures extend. In addition to the ordinary roughness presented by the microstructures, the articulation further discourages biofouling and bioadherence. The articulation of the microstructures can be oriented, and the orientations can be mixed or varied among the microstructures so that adjacent ones of the microstructures have different orientations of articulation.

The invention relates to an easy-to-use scar reduction bandage (or sticking plaster), that can be used in the case of hypertrophic scars and keloids. The invention offers a qualitatively even treatment over months by the permanent pressure achieved by the integrated scar bandage and spring. The effect can be strengthened or altered by the differing materials of upper and lower carrier sheets. Likewise, and at the same time, a supplemental treatment can be initiated by so-called storage structures in the base of the spring.

An improved therapeutic adhesive patch for application to the heel is described for treating or preventing heel disorders or conditions, such as cracked heel.

A cloth bandage includes a cloth layer portion including a single weave pattern including a uniform distribution of threads, wherein each thread includes a compound structure including a non-metallic fibrous material and metallic material, and an adhesive layer portion upon a bottom surface of the cloth layer portion configured to adhere the cloth bandage to skin of a wearer. A top surface of the cloth layer portion includes a uniform metallic appearance across the top surface. The metallic material can include silver, copper, or any oligodynamic material.

A wound dressing containing a multi-ply knit fabric, where the fabric contains a first and a second knit ply. The first knit ply contains a plurality of first yarns and forms the upper surface of the fabric. The second knit ply contains a plurality of polytetrafluoroethylene (PTFE) yarns, where the PTFE yarns have a transmission in the IR region of 8-10 μm at least about 40%, and a thermal conductivity of at least about 0.2 W/(m.Math.K) forms the lower surface of the fabric. The first ply and the second ply are integrated through combined portions formed by interlacing first yarns among the PTFE yarns of the second knit ply, interlacing PTFE yarns among the first yarns of the first knit ply, or interlacing a plurality of third yarns among the first yarns and the PTFE. The multi-ply knit fabric also contains a composition containing at least one silver ion-containing compound.

Multi-layer contact patches, as well as related apparatus, kits, systems, and methods, enable improved allergen testing and diagnosis. Multi-layer contact patches include a shield layer releasably coupled to an adhesive layer. The adhesive layer at least partially defines and is fixably coupled to an allergen complex layer. The allergen complex layer defines a plurality of allergen complex cavities. At least a subset of the allergen complex cavities include an allergen complex positioned therein, each allergen complex comprising an absorbent matrix and an allergen.

Polyurethane material for indicating pH at a locus, preferably as indication of presence of microbes, comprising a polyurethane network having immobilised therein one or more hydrophilic copolymers, the or each said copolymer comprising: hydrophilic monomer; and indicating monomer, which provides an indication in response to a change in hydrophilic state of said hydrophilic monomer and/or copolymer; characterised in that the or each copolymer further comprises one or a plurality of ionisable groups or moieties or polymerisable monomers having one or more characteristic pKa values in the range 5 to 10 and which are responsive to pH at the locus in the range pH 5 to pH 10 and in that hydrophilic state of hydrophilic copolymer is dependent on ionisation of said ionisable groups, moieties or monomers; kit and device comprising the material and process for preparation thereof; and use in detecting or sensing microbes or pH.

a film composite for manufacturing a package for planar carriers of pharmaceutical active substances, for example transdermal patches, encompassing, in a direction from the outer side of the film composite toward its inner side: a metal layer; an acrylic-acid-containing joining layer; a polyethylene layer; and a COC layer made of cycloolefin copolymer, a side of the COC layer which faces away from the metal layer being an exposed surface of the film composite, wherein provision is made that the polyethylene layer encompasses metallocene polyethylene.