This disclosure includes wound dressings and systems with remote oxygen generation for topical wound therapy and related methods. Some systems include a dressing for facilitating delivery of oxygen to the target tissue, the dressing having: a first manifold that defines a plurality of gas passageways and is configured to allow communication of oxygen to the target tissue; a gas-occlusive layer configured to be disposed over the first manifold and coupled to tissue surrounding the target tissue such that: an interior volume is defined between the gas-occlusive layer and the target tissue; and the gas-occlusive layer limits escape of oxygen from the interior volume between the gas-occlusive layer and the tissue surrounding the target tissue; a container outside the interior volume, the container having a sidewall that defines a chamber configured to be in fluid communication with the interior volume; and an oxygen-generating material disposed within the chamber of container and configured to release oxygen when exposed to water.

This invention provides wound healing systems, which delivers oxygen to the wound bed and applies negative pressure thereto, where the source of oxygen and negative pressure are simultaneously applied to distal sites of the dressing. Methods of treating wounds and methods of treating or preventing anaerobic infection of wounds using such systems are described.

A wound therapy apparatus is disclosed that includes a wound interface securable to a skin surface around a wound bed to form an enclosed space over the wound bed that is fluid-tight. The wound therapy apparatus may include a dressing engaged with the wound interface to contact the wound bed. Gas within the enclosed space may have an O.sub.2 concentration greater than the O.sub.2 concentration in atmospheric air. The dressing may include a hydrophobic material, hydrophobic material, or a distal layer comprised of silicone having fenestrations therein, in various aspects. The pressure p.sub.0 within the enclosed space may vary over a pressure range p.sub.minp.sub.0p.sub.max. Related methods of use are also disclosed.

This disclosure includes wound dressings and systems with high-flow therapeutic gas sources for topical wound therapy and related methods. Some dressings, which are configured to be coupled to tissue to facilitate delivery of therapeutic gas to the tissue, comprise a manifold that defines a plurality of gas passageways, the manifold configured to allow communication of therapeutic gas to the tissue; and a gas-occlusive layer configured to be disposed over the manifold and coupled to the tissue such that an interior volume containing the manifold is defined between the gas-occlusive layer and the tissue and the gas- occlusive layer limits escape of therapeutic gas from the interior volume; wherein the gas- occlusive layer includes: a first opening configured to allow communication of therapeutic gas into the interior volume; and one or more second openings configured to allow communication of therapeutic gas out of the interior volume.

A wound care device for delivering topical oxygen therapy, negative pressure wound therapy, and a low intensity vacuum therapy for treatment of a wound. The wound care device may include an oxygen supply mea, an oxygen consuming mea, a vacuum pump and motor, a pressure sensor, and a power supply and electronic controls. A dressing may be connected to the wound care device for administering topical continuous oxygen therapy and simultaneous negative pressure wound therapy to a wound. A canister or exudate trap may be positioned between the dressing and the vacuum supply port of the vacuum pump to collect and store exudates from the wound. The canister may be combined with the dressing.

The present disclosure provides amine-modified polymer foams, which may be used for wound dressing materials. For example, the modified materials can include a covalently attached molecule comprising free amine groups. Such amine groups can be used, for instance, to conjugate biologically active polypeptides and/or linkers. Methods for using modified polymers are also provided.

A navigation and monitoring system to track positions of surgical components during surgery of a patient. Some embodiments include a power source to emit a tracking signal during surgery of the patient, a first sensor mounted to a region of the patient to respond to the emitted tracking signal, and a control unit to track a position of the region relative to a fixed region of the patient as the region moves with respect to the fixed region, based on the response of the first sensor. The system can calibrate and register a movable reference point of the patient relative to a fixed reference point, and can maintain that reference point when the movable reference point moves in space during a surgical process.

A wound treatment system includes a housing that defines an oxygen outlet. An oxygen production subsystem is included in the housing and coupled to the oxygen outlet. A control subsystem is coupled to the oxygen production subsystem and configured to receive pressure information that is indicative of a pressure in a restricted airflow enclosure that is coupled to the oxygen outlet. The control subsystem then uses the pressure information to control power provided to the oxygen production subsystem in order to control an oxygen flow that is created by the oxygen production subsystem and provided through the oxygen outlet to the restricted airflow enclosure.

An apparatus and system for fluidly connecting a reduced-pressure source to a dressing and a method for manufacturing and using the same include a base having an aperture and a wall having a peripheral portion coupled to the base. The wall may form a cavity in fluid communication with the aperture. The apparatus also may include a conduit port fluidly coupled to the cavity and adapted to receive a conduit. The base may be adapted to couple to the dressing, and the wall may be adapted to collapse from a first position to a second position in response to a supply of reduced pressure from the reduced-pressure source.

A system for wound treatment using a serum, comprising a device for recovering serum from whole blood, comprising: a blood bag for the reception and coagulation of whole blood, which has an outlet for discharging the serum-containing fluid from the blood bag and a barrier in the region of the outlet for retaining the coagulum, a filter module which is fluidically connected to the blood bag and comprises a housing and an interior, in which a semi-permeable membrane is arranged, said membrane dividing the interior into a retentate space and a permeate space and separating the fluid discharged from the blood bag into a permeate comprising the serum and into a retentate in which any particulate components contained in the fluid remain. The system for wound treatment further comprises a wound care system with a capillary membrane system for dispensing the serum to a wound. The capillary membrane system is connected to at least one supply line, which for its part is connected to the permeate outlet of the filter module.