Apparatus and methods to treat skin defects include a pump with reservoirs for a pressurization gas and a fluid. Upon activation, the pump generates a gas introduced into the gas reservoir, a movable wall of which displaces a movable wall of a fluid source, thus dispensing the fluid into the dressing to spread throughout irrespective of orientation of the dressing, maintaining a transport fluid (e.g. carrier) in the dressing and in contact with a skin defect being treated. The dressing may have a distribution network, and multiple members, dispensing the fluid into the dressing and in contact with a skin defect being treated.

Embodiments of the disclosure may include a medical device for releasing a medicament. The device may include a multi-layer patch. The patch may include a base layer configured to secure the patch to a body of a user and a medicament array located adjacent the base layer. The array may include a plurality of wells configured to release a quantity of medicament from the array to the body of the user. The device may also include a cover layer located on a side of the medicament array opposite the base layer and a pump operably coupled to the patch and configured to deliver a quantity of fluid to the patch.

A wound care device for delivering topical oxygen therapy, negative pressure wound therapy, and a low intensity vacuum therapy for treatment of a wound. The wound care device may include an oxygen supply MEA, an oxygen consuming MEA, a vacuum pump and motor, a pressure sensor, and a power supply and electronic controls. A dressing may be connected to the wound care device for administering topical continuous oxygen therapy and simultaneous negative pressure wound therapy to a wound. A canister or exudate trap may be positioned between the dressing and the vacuum supply port of the vacuum pump to collect and store exudates from the wound. The canister may be combined with the dressing.

In various aspects, a wound therapy apparatus is disclosed herein that includes a wound interface securable to a skin surface around a wound bed to form an enclosed space over the wound bed that is fluid-tight in order to maintain a pressure p.sub.0 within the enclosed space that differs from the ambient pressure p.sub.amb. The wound therapy apparatus, in various aspects, includes a dressing engaged with the wound interface to contact the wound bed. An adhesive layer may be formed on distal surfaces of the wound interface to secure the wound interface to the skin surface. When secured to the skin surface, the wound therapy apparatus includes gas within the enclosed space having an O.sub.2 concentration greater than the O.sub.2 concentration in atmospheric air, there being no gas flow into the enclosed space or out of the enclosed space, in various aspects. The dressing may include a hydrophobic material, hydrophobic material, or a distal layer comprised of silicone having fenestrations therein, in various aspects. Related methods of use may include the step of inputting input fluid into the enclosed space or withdrawing output fluid from the enclosed space through one or more lumen to vary the pressure p.sub.0 within the enclosed space over a pressure range p.sub.minp.sub.0p.sub.max. In certain aspects, the input fluid may be a gas that may have an O.sub.2 concentration greater than the O.sub.2 concentration in atmospheric air. This Abstract is presented to meet requirements of 37 C.F.R. 1.72(b) only, and is not intended to identify key elements of the apparatus, methods, and compositions of matter disclosed herein or to delineate the scope thereof.

Systems and methods can promote wound healing, including a wound dressing having a wound-facing surface and a second surface. The wound-facing surface can be configured to contact a wound of a patient. There can also be at least one conduit having an interior lumen operably connectable to the second surface of the wound dressing, a central window configured to allow air flow from the interior lumen of the conduit to the wound-facing surface of the wound dressing, and a flexible wrap operably connectable to the conduit.

Device for the recovery of cell-free serum from whole blood, comprising a blood bag for the reception and the coagulation of the whole blood into a solid fraction and into a fluid containing a serum, wherein the blood bag has an outlet and a barrier in the area of the outlet which is suitable for retaining at least a major portion of the solid fraction and for the passage of said fluid, a filter module which is fluidically connected to the blood bag via the outlet, comprising an interior in which a semi-permeable membrane is arranged which subdivides the interior into a retentate space and a permeate space and allows the separation of the fluid into a serum as a permeate and into a retentate in which possible particulate components contained in the fluid remain, wherein the filter module has an inlet device for introducing the fluid into the retentate space and a permeate outlet for discharging the serum from the permeate space, and at least one receiving container for serum, comprising an inlet opening which is connected to the permeate outlet of the filter module via a connecting line.

Method for the recovery of cell-free serum from whole blood, wherein the method can be carried out by means of the described device.

Wound dressings and wound inserts comprising substantially dry reactive agents, methods of forming wound inserts comprising dry reactive agents, and wound-treatment methods.

A surgical or wound closure device utilizes a slide fastener for rapidly closing a surgical incision or wound with precise apposition of the sides of the incision. The surgical closure devices are configured for linear incisions, shaped incisions, such as used for wedge biopsy or excisional biopsy, and long incisions, such as used for laparotomy or surgical removal of redundant skin. The surgical closure device may be adhered to the patient's skin prior to making an incision and is subsequently used for closing the incision.

Tapes and methods including an unbacked construction of at least one liquid layer adhesive that has been at least one of dried and cured. Occlusive tissue dressings, tapes and methods including an elastomeric drape and, for backed drapes and some unbacked drapes, a liquid component, at least partially cross-linked at least after one of drying and curing, suitable for application at a dressing-to-skin interface in order to create a substantially air-tight seal. The same or a different liquid component may be applied by a user at a tube-to-dressing interface of an elastomeric drape to create a similar air-tight seal around the tube, if not occlusively sealed during its manufacture. Featured are unbacked tapes, a drape with liquid sealant component, a liquid layered drape with liquid sealant component, and a liquid layered drape.

According to an illustrative embodiment a method to promote healing of a wound is provided comprising contacting the wound with a biologically active composition comprising a lipoic acid derivative and gelatin. In another embodiment a wound dressing is provided comprising a scaffold coated with a biologically active composition comprising a lipoic acid derivative. In a further embodiment, a system is provided for treating a tissue site of a patient, the system comprising a reduced-pressure source to supply reduced pressure, a manifold to distribute reduced pressure to a tissue site and a scaffold coated with a biologically active composition comprising a lipoic acid derivative. Methods for producing such a system and scaffold are also disclosed.