The present invention relates to a composition that can be used as or as part of a wound dressing and to wound dressings comprising the same. More specifically, the present invention relates to a composition that disrupts and kills bacteria within a biofilm and also prevents biofilm formation. The composition comprises a fibrous first component selected from the group consisting of chitosan, chitin, derivatives of chitosan, derivatives of chitin, and combinations thereof; at least one triprotic acid and at least one solubilising acid.

The present invention provides thin-film forming compositions comprising an antiseptic (e.g., povidone iodine, chlorhexidine, or octenidine), a non-aqueous solvent, and a film-forming material dissolved in the non-aqueous solvent, wherein the composition yields a continuous and flexible protective film upon substantial removal of the solvent. The compositions are useful for the treatment and prevention of infections in wounds, ulcers (e.g., decubitus ulcers and stasis ulcers), cuts, or burns, or against infections from bacterial, mycobacterial, viral, fungal, or amoeba causes, as well as for prevention of such infections in appropriate clinical settings (e.g., as liquid bandages or dressings). Additionally, the compositions of this invention are also useful for the treatment of infections and as a disinfectant skin preparation for pre- and/or post-surgical operations.

Wound dressings for local application of therapeutic agents to a wound site include multilayer dressings and topical compositions for direct application to the skin, both comprising at least one therapeutic agent that is cannabidiol. The inventive wound dressings deliver and retain therapeutic agents locally at the wound site, while limiting or eliminating systemic absorption. Multilayer dressings of the invention also provide a means to add or replenish the therapeutic agent without changing the need to change the dressings.

Antimicrobial dressings for prevention and mitigation of biofilm and bacterial infection by an applied electric current are provided. Methods of making the dressings and methods of applying an electric current to promote the wound healing process are also disclosed.

A wound care device may be configured for treating, healing, or monitoring wounds. The wound care device may include a first portion that may be configured to be applied over and external to a wound and a second portion that may be in fluid communication with said first portion that may be configured to be positioned within the wound. The wound care device may wick fluid and other materials from the wound, deliver medicaments to the wound, and supply probes that communicate with displays to show wound status.

Negative pressure wound therapy sponges that are custom-fabricated to fit a given wound to be treated, corresponding methods of creating said sponges in situ or external to a wound, and related systems for performing negative pressure wound therapy using said sponges. Exemplary sponge embodiments may have pressure-sensing capabilities.

Described herein are tissue grafts derived from the placental tissue that are reinforced with at least one biocompatible mesh. The tissue grafts possess good adhesion to biological tissues and are useful in wound healing applications. Also described herein are methods for making and using the tissue grafts.

Embodiments herein are directed to a hemostatic medical device including an applicator having a receptacle with an output end and a moveable piston configured to move at least partially within the receptacle, and a plurality of liquid expandable articles disposed within the applicator, wherein each liquid expandable article has a volume greater than 50 mm.sup.3.

A system for treating a tissue site of a patient includes a dressing filler adapted to be positioned at the tissue site. The dressing filler is comprised of a porous substrate having at least one compressed region and at least one expanded region. The compressed region of the porous substrate is held in a compressed state by a first coating capable of dissolving in the presence of a fluid, and the expanded region of the porous substrate is held in an expanded state by a second coating.

Example absorbent articles including a non-adherent member comprising a polyester, a substrate adjacent the non-adherent member, and an absorbent member disposed between the non-adherent member and the substrate are disclosed. The non-adherent member defines a plurality of perforations extending through a thickness of the non-adherent member. Example techniques for forming example articles are disclosed.