The present invention relates to microclosures and methods for treating microwounds in the skin (e.g., after incising or excising tissue portions from a subject). Exemplary microclosures include a material having at least one dimension of from about 10 um to about 1 mm after application to a microwound. The microclosure maintains a first compressive force when applied to the microwound.

One aspect of the present disclosure relates to the use of vitrified active agents such as growth factors and/or one or more antimicrobial peptides (AMPs), or other desired active agent, for wound healing as a component of a wound dressing whereby the active agents are vitrified onto one or more polymeric materials, and their release rate regulated by the presence of one or more biodegradable polymeric materials.

A wound healing aid device including a spacer, a ring and pair of flaps. The spacer is configured for implantation in an open wound. The spacer is positioned in the open wound in an area below a top layer of the wound. The ring is attached to the spacer and is configured to adhere to a top layer of skin surrounding the wound area. The pair of flaps are each positioned at an opposite side of the ring. The pair of flaps are configured to overlap one another in a closed positioned and are configured to separate from one another in an open position. The pair of flaps shield the open wound in the closed position and allow access to the wound in the open position.

Disclosed are a microneedle patch including a first hydrogel layer containing a mussel adhesive protein and hyaluronic acid, and a second hydrogel layer containing silk fibroin, and a preparation method thereof. The microneedle patch according to the present disclosure has excellent tissue adhesion, biocompatibility, and biodegradability, and is used for transdermal drug delivery to promote wound regeneration.

Scar formation is inhibited by simultaneously applying a vertical force and a lateral compression to the wound site during the healing process. Apparatus for applying such simultaneous forces can include a backing and a tissue displacement device. The backing holds the tissue displacement device over the wound. The tissue displacement device may be expanded to both apply the vertical force against the wound and to draw the backing radially or laterally inward to apply the desired compression forces to the wound.

Various embodiments are directed to a therapy tape configured to enable a tensile force to be applied to one or more surfaces (e.g., a patient's skin). In various embodiments, the therapy tape may comprise a backing layer having a top surface and a bottom surface. An adhesive layer configured to secure the therapy tape to a surface may be secured relative to the bottom surface of the backing layer. Moreover, one or more handles may be secured to the top side of the backing layer. The one or more handles may be configured to enable a tensile force to be applied to the therapy tape and the surface to lift a portion of the surface while maintaining adherence between the therapy tape and the surface.

A wound dressing that incorporates a number of sensors can be utilized in order to monitor characteristics of a wound as it heals or to identify one or more risk factors or conditions that may precipitate a wound. The wound dressing can include at least one sensor, such as an impedance sensor, that may be restricted from sensing in a direction away from the wound when the wound dressing is positioned in contact with the wound.

A medical drape for use with a reduced pressure system for providing reduced pressure to a tissue site is described. In some embodiments, the drape may include a flexible film, and an adhesive layer coupled to the flexible film. The adhesive layer may include a first adhesive disposed on a first portion of the flexible film in a first pattern. The first adhesive can be configured to secure the flexible film proximate to the tissue site. The adhesive layer generally includes a second adhesive disposed on a second portion of the flexible film in a second pattern. The second adhesive can be configured to seal the flexible film proximate to the tissue site. The first pattern and the second pattern are preferably registered so that the first portion and the second portion are offset to cover substantially different portions of the flexible film.

A treatment system including one or more of a wound dressing having one or more of a substrate element, a dressing member disposed on the substrate element, an adhesive element disposed on the substrate element, and a tether connecting the wound dressing to a treatment device.

An applicator is disclosed for applying a treatment solution to a treatment site of a patient. The applicator can include an applicator housing comprising a treatment solution reservoir. A cartridge can be removably disposed in the housing. The cartridge when arranged in the housing can be in fluid communication with the treatment solution reservoir. The cartridge can include an electrostatic module for electrostatically charging the treatment solution in the treatment solution reservoir; and a nozzle for applying the treatment solution.