A wound dressing includes a dressing member or body which has a wound-facing side intended to be placed adjacent a wound, such a surgical wound. The wound-facing side of the wound dressing is provided with a plurality of microstructures in the form of denticles. Each of the denticles includes a body that extends from a base of the denticle laterally over, but not connected to, the dressing member. The denticles are arranged in an overlapping manner such that the body of one denticle overlaps the body of one or two other adjacent denticles. The denticles create a microstructured surface that resists bioadhesion, and which, upon flex of the wound dressing, create mechanical interference with each other that can dislodge organisms that manage to adhere to the wound-facing side of the wound dressing in spite of the microstructured surface.

A method for manufacturing a steel sheet having a yield strength YS of more than 1000 MPa, a tensile strength TS of more than 1150 MPa and a total elongation E of more than 8%, comprising the steps of: —preparing a steel sheet through rolling from a steel containing in percent by weight 0.19% to 0.22% C, 2% to 2.6% Mn, 1.45% to 1.55% Si, 0.15% to 0.4% Cr, less than 0.020% P, less than 0.05% S, less than 0.08% N, 0.015% to 0.070% Al, the reminder being Fe and unavoidable impurities, —soaking the sheet at an annealing temperature TA between 860° C. and 890° C. for a time between 100 s and 210 s, cooling the sheet to a quenching temperature QT between 220° C. and 330° C., from a temperature TC not less than 500° C. at a cooling speed not less than 15° C./s, heating the steel sheet during a time between 115 s and 240 s up to a first overaging temperature TOA1 higher than 380° C., then heating the sheet during a time between 300 s and 610 s up to a second overaging temperature TOA2 between 420° and 450° C., cooling the steel sheet to a temperature less than 100° C. at a cooling speed less than 5° C./s. The structure of the steel containing more than 80% of tempered martensite, more than 5% of retained austenite, less than 5% of ferrite, less than 5% of bainite and less than 6% of fresh martensite.

Described herein are adhesive support devices, which may include adhesive medical devices. In particular, three-dimensional adhesive medical devices from a single layer of material, typically by stamping or pressing (including cold pressing) a sheet of the material to form rigid and complex 3D shapes capable of use for a variety of medical and non-medical purposes. These adhesive support devices typically also include an adhesive material allowing the device to be attached to a subject's skin and/or mounted on a surface (e.g., wall, etc.). In particular, described herein are methods of manufacturing, assembling, and using adhesive support devices.

One example embodiment includes a pre-cut strip of kinesiology tape. The pre-cut strip of kinesiology tape includes a fabric. The fabric includes a weave of fibers, where the fibers include an elastic fiber covered by a covering material. The fabric also includes a first end and a second end, where the second end is opposite the first end. The fabric further includes one or more rounded corners. The pre-cut strip of kinesiology tape also includes a longitudinal cut in the fabric. The longitudinal cut passes through at least a portion of the fabric and extends from the first end to a predetermined distance from the second end. The pre-cut strip of kinesiology tape also includes adhesive on a first surface of the fabric, where the adhesive is configured to adhere the fabric to a human body.

The present disclosure provides a composite dressing comprising a combination of porous matrix and fabric substrate wherein at least one of said porous matrix and fabric substrate is composed biomaterial(s) and wherein the fabric substrate is at least partially embedded in the porous matrix. Further, the disclosure provides a method for preparation of said composite dressing, wherein said method enables production of the composite dressing having cohesive bonding between porous matrix and fabric support without use of any adhesive, stitching or chemical crosslinking agent between the two layers. The composite dressing exhibits high peel strength in both dry and wet conditions and has applications such as hemostatic dressings for deep cavity wounds, puncture wounds, post-partum hemorrhage and internal hemostatic agents.

The disclosure provides new medical device and manufacturing methods as well as chemicals that enhance delivery of pharmaceuticals from a transdermal patch, where the patch may include a film, adhesive, emulsifier, tackifier, or hydrogel.

The disclosure provides complexes for desired usage as as chemical groups that enhance delivery of moieties from a buccal setting or from a transdermal patch, where the CBD unexepectely enhances the transmission and availability of actives.

The present invention relates inter alia to an apparatus for providing a coiled collagen carrier. An apparatus according to the invention preferably comprises a device for applying moisture to a collagen carrier prior to coiling of the collagen carrier and a coiling device. The coiling device preferably comprises rotatable gripping means for gripping the collagen carrier along an edge and coiling the collagen carrier, and a support device supporting the collagen carrier while being coiled. In another aspect, the invention relates to a production facility wherein an apparatus according to invention is arranged.

The present invention relates to transdermal therapeutic systems (TTS) for the transdermal administration of solifenacin.

The present invention concerns a transdermal delivery system (TDS) comprising at least one active ingredient, wherein the active ingredient is in a non-aqueous matrix, and wherein the non-aqueous matrix has a reduced moisture content. Furthermore, the present invention concerns a method for the production of the TDS in accordance with the invention, as well as the use of the TDS in accordance with the invention.