A novel salt of treprostinil and methods of its preparation and use are disclosed.

The invention relates to an organic ammonium salt of formula (I), wherein the symbols have the following meanings: A- is an anionic pesticide, R.sup.1 is H, C.sub.1C.sub.4-alkyl, CH.sub.2CH.sub.2OH or CH.sub.2CH(CH.sub.3)OH; R is H, CH.sub.3 or two adjacent radicals R together form a group —C(R′)— and R′ is equal to or different from H or CH.sub.3, wherein said salt is suitable for reducing the volatility of active substances in the spray application of anionic pesticides.

##STR00001##

The invention relates to an organic ammonium salt of formula (I), wherein the symbols have the following meanings: A- is an anionic pesticide, R.sup.1 is H, C.sub.1C.sub.4-alkyl, CH.sub.2CH.sub.2OH or CH.sub.2CH(CH.sub.3)OH; R is H, CH.sub.3 or two adjacent radicals R together form a group —C(R′)— and R′ is equal to or different from H or CH.sub.3, wherein said salt is suitable for reducing the volatility of active substances in the spray application of anionic pesticides.

##STR00001##

The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia.

The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia.

Treprostinil is a synthetic prostacyclin derivative with thrombocyte aggregation inhibitory and vasodilatory activity. Treprostinil can be administered in subcutaneous, intravenous, inhalable, or oral forms. Disclosed is a method for the preparation of treprostinil of formula I and its amorphous form, anhydrate form, monohydrate form, and polyhydrate form salts with bases. In the disclosed method, the chiral center in the 3-hydroxyoctyl substituent is formed at the end of the synthesis, so that the method is robust and well scalable. Also disclosed are treprostinil intermediates and the preparation of the intermediates. ##STR00001##

Treprostinil is a synthetic prostacyclin derivative with thrombocyte aggregation inhibitory and vasodilatory activity. Treprostinil can be administered in subcutaneous, intravenous, inhalable, or oral forms. Disclosed is a method for the preparation of treprostinil of formula I and its amorphous form, anhydrate form, monohydrate form, and polyhydrate form salts with bases. In the disclosed method, the chiral center in the 3-hydroxyoctyl substituent is formed at the end of the synthesis, so that the method is robust and well scalable. Also disclosed are treprostinil intermediates and the preparation of the intermediates. ##STR00001##

Compounds provided herein function as thyromimetics and have utility for treating diseases such as neurodegenerative disorders and fibrotic diseases. Pharmaceutical compositions containing such compounds are also provided, as are methods of their preparation.

Compounds are provided herein function as thyromimetics and have utility for treating diseases such as neurodegenerative disorders and fibrotic diseases. Pharmaceutical compositions containing such compounds are also provided, as are methods of their preparation.

Compounds are provided herein function as thyromimetics and have utility for treating diseases such as neurodegenerative disorders and fibrotic diseases. Pharmaceutical compositions containing such compounds are also provided, as are methods of their preparation.