Disclosed are succinimide-based compounds used in compositions and methods for inhibiting natural gas hydrate agglomerates. The succinimide-based compounds are reaction products of an alkenyl succinic anhydride and an amine or amine alcohol.

Disclosed are succinimide-based compounds used in compositions and methods for inhibiting natural gas hydrate agglomerates. The succinimide-based compounds are reaction products of an alkenyl succinic anhydride and an amine or amine alcohol.

Provided herein are dUTPase inhibitors of Formula (I), compositions comprising such compounds and methods of using such compounds and compositions ##STR00001##

Provided herein are dUTPase inhibitors of Formula (I), compositions comprising such compounds and methods of using such compounds and compositions ##STR00001##

Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.

Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.

This disclosure relates to inhibitors of IRES-mediated protein synthesis, compositions comprising therapeutically effective amounts of these compounds, and methods of using those compounds and compositions in treating hyperproliferative disorders, e.g., cancers. This disclosure also relates to compositions comprising inhibitors of IRES-mediated protein synthesis and mTOR inhibitors, and to methods of treating cancer by conjoint administration of inhibitors of IRES-mediated protein synthesis and mTOR inhibitors.

The present disclosure relates to a gas hydrate inhibitor composition comprising A) a compound according to formula (1)

##STR00001##

wherein R1 is an alkyl group having from 1 to 5 carbon atoms; R2 is hydrogen or an alkyl group having from 1 to 5 carbon atoms; R3 is present or not as hydrogen and organic moieties having from 1 to 20 carbon atoms; R4 is selected from —(CH2)t-, —[(CH2-CHR6)t]-, —(CH2-CHR6O)u-(CH2)t- and combinations thereof; R5 is an alkyl or alkenyl group having 4 to 22 carbon atoms; R6 is hydrogen or an alkyl group having from 1 to 4 carbon atoms; R7 is hydrogen or an alkyl group having from 1 to 4 carbon atoms; R8 is present or not as hydrogen or organic moieties having from 1 to 20 carbon atoms; t is 2, 3 or 4; u is an integer between 0 and 100; n is 0 or 1 m is 0 or 2 o is 0 or 2 p is 0 or 1 X− is an anion, and and a a synergistic surfactant which is selected from the group consisting of N-acylated polyhydroxyalkylamines and a method of using the gas hydrate inhibitor composition.

The present disclosure relates to a gas hydrate inhibitor composition comprising from an amphiphile having a hydrophobic tail linked to a hydrophilic head group by a linking moiety, the amphiphile having the general formula (1)

[R.sup.5-L-N(R.sup.1)(R.sup.2)(R.sup.3)].sup.+X.sup.−  (1) wherein each of R.sup.1and R.sup.2 is independently an alkyl group having from 1 to 5 carbon atoms; or wherein the nitrogen atom and the R.sup.1and R.sup.2 groups together form a substituted or unsubstituted heterocyclic group; R.sup.3 is present or not as hydrogen or an alkyl group having from 1 to 8 carbon atoms which optionally bears a hydroxy group or a carboxy group in the 2-position; L is a linking moiety comprising an optionally substituted hydrocarbyl group having at least 2 adjacent carbon atoms, at least one heteroatom selected from nitrogen and oxygen, and optionally one or more further heteroatoms; R.sup.5 is a hydrocarbyl group having from 6 to 22 carbon atoms; and X.sup.− is present as an anion when R.sup.3 is present; and

from a cationic surfactant which is selected from di(C.sub.8-C.sub.18 alkyl)dimethyl ammonium salts.

The present disclosure relates to a gas hydrate inhibitor composition comprising from an amphiphile having a hydrophobic tail linked to a hydrophilic head group by a linking moiety, the amphiphile having the general formula (1)

[R.sup.5-L-N(R.sup.1)(R.sup.2)(R.sup.3)].sup.+X.sup.−  (1) wherein each of R.sup.1and R.sup.2 is independently an alkyl group having from 1 to 5 carbon atoms; or wherein the nitrogen atom and the R.sup.1and R.sup.2 groups together form a substituted or unsubstituted heterocyclic group; R.sup.3 is present or not as hydrogen or an alkyl group having from 1 to 8 carbon atoms which optionally bears a hydroxy group or a carboxy group in the 2-position; L is a linking moiety comprising an optionally substituted hydrocarbyl group having at least 2 adjacent carbon atoms, at least one heteroatom selected from nitrogen and oxygen, and optionally one or more further heteroatoms; R.sup.5 is a hydrocarbyl group having from 6 to 22 carbon atoms; and X.sup.− is present as an anion when R.sup.3 is present; and

from a cationic surfactant which is selected from di(C.sub.8-C.sub.18 alkyl)dimethyl ammonium salts.