The present disclosure relates to a gas hydrate inhibitor composition, comprising A) a compound according to formula (1)

##STR00001##

wherein R1 is an alkyl group having from 1 to 5 carbon atoms; R2 is hydrogen or an alkyl group having from 1 to 5 carbon atoms; R3 is present or not as hydrogen and organic moieties having from 1 to 20 carbon atoms; R4 is selected from —(CH.sub.2).sub.t—, —[CH.sub.2—CHR.sup.6).sub.t]—, —(CH.sub.2—CHR.sup.6O).sub.u—(CH.sub.2).sub.t— and combinations thereof; R5 is an alkyl or alkenyl group having 4 to 22 carbon atoms; R6 is hydrogen or an alkyl group having from 1 to 4 carbon atoms; R7 is hydrogen or an alkyl group having from 1 to 4 carbon atoms; R8 is present or not as hydrogen or organic moieties having from 1 to 20 carbon atoms; t is 2, 3 or 4; u is an integer between 0 and 100; n is 0 or 1 m is 0 or 2 o is 0 or 2, p is 0 or 1 X.sup.− is an anion, and B) a compound that is a synergistic surfactant which comprises an quaternary alkyl ammonium compound.

The present disclosure relates to a gas hydrate inhibitor composition comprising an amphiphile having a hydrophobic tail linked to a hydrophilic head group by a linking moiety, the amphiphile having the general formula (1)

[R.sup.5-L-N(R.sup.1)(R.sup.2)(R.sup.3)].sup.+X.sup.−  (1) wherein each of R.sup.1 and R.sup.2 is independently an alkyl group having from 1 to 5 carbon atoms; or wherein the nitrogen atom and the R.sup.1 and R.sup.2 groups together form a substituted or unsubstituted heterocyclic group; R.sup.3 is present or not as hydrogen or an alkyl group having from 1 to 8 carbon atoms which optionally bears a hydroxy group or a carboxy group in the 2-position; L is a linking moiety comprising an optionally substituted hydrocarbyl group having at least 2 adjacent carbon atoms, at least one heteroatom selected from nitrogen and oxygen, and optionally one or more further heteroatoms; R.sup.5 is a hydrocarbyl group having from 6 to 22 carbon atoms; and X.sup.− is present as an anion when R.sup.3 is present; and a cationic surfactant which is selected from quaternary benzyl ammonium salts having besides the benzyl group at least one C.sub.8-C.sub.18-alkyl group bound to the nitrogen atom and a method of using the gas hydrate inhibitor composition.

The present disclosure relates to a gas hydrate inhibitor composition, comprising A) a compound according to formula (1)

##STR00001##

wherein R1 is an alkyl group having from 1 to 5 carbon atoms; R2 is hydrogen or an alkyl group having from 1 to 5 carbon atoms; R3 is present or not as hydrogen and organic moieties having from 1 to 20 carbon atoms; R4 is selected from —(CH.sub.2).sub.t—, —[CH.sub.2—CHR.sup.6).sub.t]—, —(CH.sub.2—CHR.sup.6O).sub.u—(CH.sub.2).sub.t— and combinations thereof; R5 is an alkyl or alkenyl group having 4 to 22 carbon atoms; R6 is hydrogen or an alkyl group having from 1 to 4 carbon atoms; R7 is hydrogen or an alkyl group having from 1 to 4 carbon atoms; R8 is present or not as hydrogen or organic moieties having from 1 to 20 carbon atoms; t is 2, 3 or 4; u is an integer between 0 and 100; n is 0 or 1 m is 0 or 2 o is 0 or 2, p is 0 or 1 X.sup.− is an anion, and a synergistic cationic surfactant which is selected from quaternary benzyl ammonium salts having besides the benzyl group at least one C.sub.8-C.sub.18-alkyl group bound to the nitrogen atom.

The present disclosure relates to a gas hydrate inhibitor composition comprising an amphiphile having a hydrophobic tail linked to a hydrophilic head group by a linking moiety, the amphiphile having the general formula (1)

[R.sup.5-L-N(R.sup.1)(R.sup.2)(R.sup.3)].sup.+X.sup.−  (1) wherein each of R.sup.1 and R.sup.2 is independently an alkyl group having from 1 to 5 carbon atoms; or wherein the nitrogen atom and the R.sup.1 and R.sup.2 groups together form a substituted or unsubstituted heterocyclic group; R.sup.3 is present or not as hydrogen or an alkyl group having from 1 to 8 carbon atoms which optionally bears a hydroxy group or a carboxy group in the 2-position; L is a linking moiety comprising an optionally substituted hydrocarbyl group having at least 2 adjacent carbon atoms, at least one heteroatom selected from nitrogen and oxygen, and optionally one or more further heteroatoms; R.sup.5 is a hydrocarbyl group having from 6 to 22 carbon atoms; and X.sup.− is present as an anion when R.sup.3 is present; and a nonionic surfactant which is selected from alkoxylated C.sub.8-C.sub.18 fatty alcohols, alkoxylated C.sub.8-C.sub.18 fatty amines, alkoxylated C.sub.8-C.sub.18 fatty acids and alkoxylated C.sub.8-C.sub.18 fatty acid amides and a method of using the gas hydrate inhibitor composition.

The present disclosure relates to a gas hydrate inhibitor composition comprising an amphiphile having a hydrophobic tail linked to a hydrophilic head group by a linking moiety, the amphiphile having the general formula (1)

[R.sup.5-L-N(R.sup.1)(R.sup.2)(R.sup.3)].sup.+X.sup.−  (1) wherein each of R.sup.1 and R.sup.2 is independently an alkyl group having from 1 to 5 carbon atoms; or wherein the nitrogen atom and the R.sup.1 and R.sup.2 groups together form a substituted or unsubstituted heterocyclic group; R.sup.3 is present or not as hydrogen or an alkyl group having from 1 to 8 carbon atoms which optionally bears a hydroxy group or a carboxy group in the 2-position; L is a linking moiety comprising an optionally substituted hydrocarbyl group having at least 2 adjacent carbon atoms, at least one heteroatom selected from nitrogen and oxygen, and optionally one or more further heteroatoms; R.sup.5 is a hydrocarbyl group having from 6 to 22 carbon atoms; and X.sup.− is present as an anion when R.sup.3 is present; and a nonionic surfactant which is selected from alkoxylated C.sub.8-C.sub.18 fatty alcohols, alkoxylated C.sub.8-C.sub.18 fatty amines, alkoxylated C.sub.8-C.sub.18 fatty acids and alkoxylated C.sub.8-C.sub.18 fatty acid amides and a method of using the gas hydrate inhibitor composition.

The present disclosure relates to a gas hydrate inhibitor composition comprising A) a compound according to formula

##STR00001##

wherein R1 is an alkyl group having from 1 to 5 carbon atoms; R2 is hydrogen or an alkyl group having from 1 to 5 carbon atoms; R3 is present or not as hydrogen and organic moieties having from 1 to 20 carbon atoms; R4 is selected from -(CH2)t-, -[(CH2-CHR6)t]-, -(CH2-CHR60)u-(CH2)t-and combinations thereof; R5 is an alkyl or alkenyl group having 4 to 22 carbon atoms; R6 is hydrogen or an alkyl group having from 1 to 4 carbon atoms; R7 is hydrogen or an alkyl group having from 1 to 4 carbon atoms; R8 is present or not as hydrogen or organic moieties having from 1 to 20 carbon atoms; t is 2, 3 or 4; u is an integer between 0 and 100; n is 0 or 1 m is 0 or 2 0 is 0 or 2 P is 0 or 1 X- and is an anion, and a nonionic surfactant which is selected from alkoxylated C.sub.8-C.sub.18 fatty alcohols, alkoxylated C.sub.8-C.sub.18 fatty amines, alkoxylated C.sub.8-C.sub.18 fatty acids and alkoxylated C.sub.8-C.sub.18 fatty acid amides and a method of using the gas hydrate inhibitor composition.

The present disclosure relates to a gas hydrate inhibitor composition comprising an amphiphile having a hydrophobic tail linked to a hydrophilic head group by a linking moiety, the amphiphile having the general formula (1)

[R.sup.5-L-N(R.sup.1)(R.sup.2)(R.sup.3)].sup.+X.sup.−  (1) wherein each of R.sup.1 and R.sup.2 is independently an alkyl group having from 1 to 5 carbon atoms; or wherein the nitrogen atom and the R.sup.1 and R.sup.2 groups together form a substituted or unsubstituted heterocyclic group; R.sup.3 is present or not as hydrogen or an alkyl group having from 1 to 8 carbon atoms which optionally bears a hydroxy group or a carboxy group in the 2-position; L is a linking moiety comprising an optionally substituted hydrocarbyl group having at least 2 adjacent carbon atoms, at least one heteroatom selected from nitrogen and oxygen, and optionally one or more further heteroatoms; R.sup.5 is a hydrocarbyl group having from 6 to 22 carbon atoms; and X.sup.− is present as an anion when R.sup.3 is present; and a nonionic surfactant which is selected from N-acylated polyhydroxyalkylamines and a method of using the gas hydrate inhibitor composition.

There are provided compounds of formula (I)

##STR00001##

in which R.sub.2, R.sub.2, R.sub.3, R.sub.4 and Q can represent various different possibilities. These compounds can be useful as anticancer agents as well as anti-inflammatory agents, anti-proliferative agents and/or anti-metastatic agents.

There are provided compounds of formula (I)

##STR00001##

in which R.sub.2, R.sub.2, R.sub.3, R.sub.4 and Q can represent various different possibilities. These compounds can be useful as anticancer agents as well as anti-inflammatory agents, anti-proliferative agents and/or anti-metastatic agents.

Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.