C07D213/12

N-Methyl Pyrazoles

This invention provides, among other things, compounds useful for treating viral infections, pharmaceutical formulations containing such compounds, as well as methods of inhibiting the replication of a virus or treating a disease.

Pyrazole-substituted arylamides as P2X3 and P2X2/3 antagonists

Compounds of the formula I: ##STR00001##
or a pharmaceutically acceptable salt thereof, wherein, R.sup.1 is optionally substituted pyrazolyl, and R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X.sub.3 and/or a P2X.sub.2/3 receptor antagonists and methods of making the compounds.

Pyrazole-substituted arylamides as P2X3 and P2X2/3 antagonists

Compounds of the formula I: ##STR00001##
or a pharmaceutically acceptable salt thereof, wherein, R.sup.1 is optionally substituted pyrazolyl, and R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X.sub.3 and/or a P2X.sub.2/3 receptor antagonists and methods of making the compounds.

HETEROCYCLIC COMPOUNDS HAVING CHOLESTEROL 24-HYDROXYLASE ACTIVITY

An object of the present invention is to provide a compound having a superior CH24H inhibitory action, which is useful as an agent for the prophylaxis or treatment of epilepsy, neurodegenerative disease and the like. The present invention relates to a compound represented by the formula:

##STR00001##

wherein each symbol is as defined in the specification, or a salt thereof.

Heterocyclic compounds having cholesterol 24-hydroxylase activity

An object of the present invention is to provide a compound having a superior CH24H inhibitory action, which is useful as an agent for the prophylaxis or treatment of epilepsy, neurodegenerative disease and the like. The present invention relates to a compound represented by the formula: ##STR00001##
wherein each symbol is as defined in the specification, or a salt thereof.

Heterocyclic compounds having cholesterol 24-hydroxylase activity

An object of the present invention is to provide a compound having a superior CH24H inhibitory action, which is useful as an agent for the prophylaxis or treatment of epilepsy, neurodegenerative disease and the like. The present invention relates to a compound represented by the formula: ##STR00001##
wherein each symbol is as defined in the specification, or a salt thereof.

Hematopoietic growth factor mimetic small molecule compounds and their uses

The present embodiments relate to compounds with physiological effects, such as the activation of hematopoietic growth factor receptors. The present embodiments also relate to use of the compounds to treat a variety of conditions, diseases and ailments such as hematopoietic conditions and disorders.

Hematopoietic growth factor mimetic small molecule compounds and their uses

The present embodiments relate to compounds with physiological effects, such as the activation of hematopoietic growth factor receptors. The present embodiments also relate to use of the compounds to treat a variety of conditions, diseases and ailments such as hematopoietic conditions and disorders.

PYRAZOLE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS

Compounds of the formula I:

##STR00001##

or a pharmaceutically acceptable salt thereof, wherein, R.sup.1 is optionally substituted pyrazolyl, and R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X.sub.3 and/or a P2X.sub.2/3 receptor antagonists and methods of making the compounds.

Combination pharmaceutical agents as RSV inhibitors

The present invention relates to a pharmaceutical composition useful for treating a Respiratory Syncytial Virus (RSV) infection, comprising a compound which is ##STR00001##
or a pharmaceutically acceptable salt thereof, and a second anti-respiratory syncytial virus agent.