The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.

Described herein is a chemical class of odorless thiols which can serve as reducing agents. This chemical class involves thiols which can be used as reducing agents for permanent styling treatments, depilatory compositions and other applications. The odorless thiols are thiols having a heterocyclic quaternary ammonium salt in their molecule.

Described herein is a chemical class of odorless thiols which can serve as reducing agents. This chemical class involves thiols which can be used as reducing agents for permanent styling treatments, depilatory compositions and other applications. The odorless thiols are thiols having a heterocyclic quaternary ammonium salt in their molecule.

The invention relates to 1-(3-sulfonylphenyl)-3-(cyclopent-2-en-1-yl)urea derivatives, and their use in treating or preventing diseases and conditions mediated by the CXCR2 receptor In addition, the invention relates to compositions containing the derivatives and processes for their preparation. ##STR00001##

An alkyl phenyl sulfide derivative represented by the general formula [I] or an agriculturally acceptable salt thereof, and a pest control agent containing the derivative or the salt as an active ingredient. ##STR00001##
[in the above formula, R.sup.1 is, for example, a C.sub.1C.sub.6 alkyl group which is mono- or poly-substituted with halogen atom; R.sup.2 is, for example, a halogen atom or a C.sub.1C.sub.6 alkyl group; R.sup.3 is, for example, a hydrogen atom or a halogen atom; and R.sup.4 is, for example, a hydrogen atom or a C.sub.1C.sub.12 alkyl group.] The derivative or the salt has an excellent pest control effect.

An alkyl phenyl sulfide derivative represented by the general formula [I] or an agriculturally acceptable salt thereof, and a pest control agent containing the derivative or the salt as an active ingredient. ##STR00001##
[in the above formula, R.sup.1 is, for example, a C.sub.1C.sub.6 alkyl group which is mono- or poly-substituted with halogen atom; R.sup.2 is, for example, a halogen atom or a C.sub.1C.sub.6 alkyl group; R.sup.3 is, for example, a hydrogen atom or a halogen atom; and R.sup.4 is, for example, a hydrogen atom or a C.sub.1C.sub.12 alkyl group.] The derivative or the salt has an excellent pest control effect.

Disclosed are compounds of formula:

##STR00001##

that inhibiting GPBP activity, making them useful as therapeutics in antibody-mediated disorders, drug-resistant cancer, inflammation, protein misfolding and ER stress-mediated disorders, and aberrant apoptosis.

Disclosed are compounds of formula:

##STR00001##

that inhibiting GPBP activity, making them useful as therapeutics in antibody-mediated disorders, drug-resistant cancer, inflammation, protein misfolding and ER stress-mediated disorders, and aberrant apoptosis.

The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.

The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.