C07D213/48

METHODS OF PREPARATION OF HETEROCYCLIC COMPOUNDS
20250145623 · 2025-05-08 ·

Provided herein are methods of preparation of compound 101.

##STR00001##

Also provided are intermediate compounds useful in the preparation of compound 101, and methods of preparation of those intermediate compounds.

Process for the preparation of substituted pyridine compounds and intermediates thereof

The present invention discloses a process for the preparation of substituted pyridine compounds of formula (I), comprises a step in which vinylogous nitriles of formula (II), are obtained from substituted ,-unsaturated nitrile compounds of formula (III), and a further step of converting the vinylogous nitrile compounds of formula (II) into substituted pyridines of formula (I); wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and LG are as defined in the description. ##STR00001##

Process for the preparation of substituted pyridine compounds and intermediates thereof

The present invention discloses a process for the preparation of substituted pyridine compounds of formula (I), comprises a step in which vinylogous nitriles of formula (II), are obtained from substituted ,-unsaturated nitrile compounds of formula (III), and a further step of converting the vinylogous nitrile compounds of formula (II) into substituted pyridines of formula (I); wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and LG are as defined in the description. ##STR00001##