Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.

There is provided compounds of formula (I) or pharmaceutically-acceptable salts thereof, wherein L, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and n have meanings provided in the description, which compounds are useful in the treatment of cancers. ##STR00001##

There is provided compounds of formula (I) or pharmaceutically-acceptable salts thereof, wherein L, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and n have meanings provided in the description, which compounds are useful in the treatment of cancers. ##STR00001##

The present invention relates to compounds of the formula (1) which are suitable for use in electronic devices, in particular organic electroluminescent devices, and to electronic devices which comprise these compounds.

The present invention provides compounds of Formula (I) wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments. ##STR00001##

A desired antibody or antibody composition may be obtained by modifying a thiol group chemically introduced to an antibody to obtain an antibody composition comprising (A) an antibody intermediate or a salt thereof having a bioorthogonal functional group which may be protected, which is represented by the following formula (A):

AbS-L-R].sub.n(A) wherein Ab is a certain antibody, S is a sulfur atom, L is a divalent group, R is a bioorthogonal functional group which may be protected, and n is an integer from 1 to 8, and (B) a thiol group-introduced antibody or a salt thereof, which is represented by the following formula (B):

AbSH].sub.n(B) wherein Ab and n are the same as formulae (A), and SH is a thiol group; and the like.

A desired antibody or antibody composition may be obtained by modifying a thiol group chemically introduced to an antibody to obtain an antibody composition comprising (A) an antibody intermediate or a salt thereof having a bioorthogonal functional group which may be protected, which is represented by the following formula (A):

AbS-L-R].sub.n(A) wherein Ab is a certain antibody, S is a sulfur atom, L is a divalent group, R is a bioorthogonal functional group which may be protected, and n is an integer from 1 to 8, and (B) a thiol group-introduced antibody or a salt thereof, which is represented by the following formula (B):

AbSH].sub.n(B) wherein Ab and n are the same as formulae (A), and SH is a thiol group; and the like.

The present invention relates to compounds of formula (I) wherein Q is selected from O or S; R.sup.1 is a saturated or unsaturated, optionally substituted hydrocarbyl group optionally including one or more heteroatoms N, O or S; R.sup.2 is a cyclic group substituted at the a and a positions, wherein the substituent at the -position is a monovalent heterocyclic group or a monovalent aromatic group, wherein the heterocyclic or aromatic group may optionally be substituted, and wherein the cyclic group may optionally be further substituted; R.sup.3 and R.sup.4 are each independently hydrogen, halogen, OH, NH.sub.2, CN, R.sup.5, OR.sup.5, NHR.sup.5 or N(R.sup.5).sub.2; or R.sup.3 and R.sub.4 together with the carbon atom to which they are attached may form a 3- to 7-membered saturated or unsaturated, optionally substituted cyclic group; and R.sup.5 is independently optionally substituted C.sub.1-C.sub.4 alkyl. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.

##STR00001##

The present disclosure provides an electrolyte and an electrochemical energy storage device, the electrolyte comprises an electrolyte salt and an additive. The additive comprises a sulfonic ester cyclic quaternary ammonium salt and a multinitrile compound. The sulfonic ester cyclic quaternary ammonium salt and the multinitrile compound can form a dense and uniform passive film with high ionic conductivity on a surface of each of the positive electrode film and the negative electrode film, so as to prevent continuous oxidation and reduction reaction from occurring between the electrolyte and the positive electrode film and the negative electrode film and make the electrochemical energy storage device has excellent high temperature cycle performance and high temperature storage performance.

The present disclosure provides an electrolyte and an electrochemical energy storage device, the electrolyte comprises an electrolyte salt and an additive. The additive comprises a sulfonic ester cyclic quaternary ammonium salt and a multinitrile compound. The sulfonic ester cyclic quaternary ammonium salt and the multinitrile compound can form a dense and uniform passive film with high ionic conductivity on a surface of each of the positive electrode film and the negative electrode film, so as to prevent continuous oxidation and reduction reaction from occurring between the electrolyte and the positive electrode film and the negative electrode film and make the electrochemical energy storage device has excellent high temperature cycle performance and high temperature storage performance.