There is provided compounds of formula I (I) or pharmaceutically-acceptable salts thereof, wherein L, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and n have meanings provided in the description, which compounds are useful in the treatment of cancers.

##STR00001##

There is provided compounds of formula I (I) or pharmaceutically-acceptable salts thereof, wherein L, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and n have meanings provided in the description, which compounds are useful in the treatment of cancers.

##STR00001##

The present invention provides new arylsulfonamide compounds having the general formula (I)

##STR00001##

wherein L, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

A heterocyclic compound is represented by formula (I): ##STR00001##
in which R.sup.2 represents a C1-C6 alkyl group optionally having one or more halogen atoms, n is 0, R.sup.3 represents a C1-C6 chain hydrocarbon group optionally having one or more substituents selected from Group B, q is 0, Het represents a group represented by the formulae Het 1 or Het 2, A.sup.1 represents a nitrogen atom, and Q.sup.2 represents an oxygen atom. The compound has excellent efficacy for controlling harmful arthropods. A composition is provided which contains the compound of formula (I) and one or more additional ingredients.

A heterocyclic compound is represented by formula (I): ##STR00001##
in which R.sup.2 represents a C1-C6 alkyl group optionally having one or more halogen atoms, n is 0, R.sup.3 represents a C1-C6 chain hydrocarbon group optionally having one or more substituents selected from Group B, q is 0, Het represents a group represented by the formulae Het 1 or Het 2, A.sup.1 represents a nitrogen atom, and Q.sup.2 represents an oxygen atom. The compound has excellent efficacy for controlling harmful arthropods. A composition is provided which contains the compound of formula (I) and one or more additional ingredients.

The present invention relates to the photoredox-mediated functionalization of proteins with chemical groups via radical generated C—C bond formation, by using specific boronate and sulfone precursor compounds. The present invention also relates to functionalized proteins that can be generated via this method and to the specific boronate and sulfone precursor compounds themselves.

The present invention relates to the photoredox-mediated functionalization of proteins with chemical groups via radical generated C—C bond formation, by using specific boronate and sulfone precursor compounds. The present invention also relates to functionalized proteins that can be generated via this method and to the specific boronate and sulfone precursor compounds themselves.

In one aspect, compounds of Formulae (I) and (II), or pharmaceutically acceptable salts thereof, are featured; Formula (I), Formula (II) or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formulae (I) and (II) can be as defined anywhere herein. ##STR00001##

In one aspect, compounds of Formulae (I) and (II), or pharmaceutically acceptable salts thereof, are featured; Formula (I), Formula (II) or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formulae (I) and (II) can be as defined anywhere herein. ##STR00001##

The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I:

##STR00001##

wherein A, X, Y R.sub.1, R.sub.2, R.sub.3, R.sub.4, m and n are as described herein.