The present invention provides compounds which can regulate VCP activity. The present invention provides the compound of formula (I) ##STR00001##
(R is as defined in the description)
or oxides, esters, prodrugs, pharmaceutically acceptable salts or solvates thereof. The compounds can regulate VCP activity, and thus are useful for treating VCP-mediated diseases such as neurodegenerative diseases.

The present invention provides compounds which can regulate VCP activity. The present invention provides the compound of formula (I) ##STR00001##
(R is as defined in the description)
or oxides, esters, prodrugs, pharmaceutically acceptable salts or solvates thereof. The compounds can regulate VCP activity, and thus are useful for treating VCP-mediated diseases such as neurodegenerative diseases.

The invention relates to compounds of the formula (I):

##STR00001## in which R.sup.0 is C.sub.1-C.sub.6-alkyl or CF.sub.3; R.sup.1 is sulfo, carboxyl, C.sub.1-C.sub.4-alkylenesulfo, C.sub.1-C.sub.4-alkylenecarboxy, CONH.sub.2, CONH(C.sub.1-C.sub.4-alkyl) or CN, R.sup.2 is C.sub.1-C.sub.18-alkyl, C.sub.2-C.sub.18-alkenyl, hydroxy-C.sub.1-C.sub.18-alkyl, or (C.sub.1-C.sub.6-alkylene-O).sub.mR where R is defined as H, C.sub.1-C.sub.16-alkyl or hydroxy-C.sub.1-C.sub.16-alkyl and m is a number from 1 to 20, R.sup.3 is H, sulfo, carboxyl, C.sub.1-C.sub.6-alkyl or C.sub.1-C.sub.6-alkoxy, R.sup.4 is H, C.sub.1-C.sub.6-alkyl or C.sub.1-C.sub.6-alkoxy, R.sup.5 is OH, OM, C.sub.1-C.sub.6-alkyl, unsubstituted C.sub.6-C.sub.10-aryl or C.sub.1-C.sub.6-alkyl-, halogen-(e.g. F, Cl, Br), carboxyl- or sulfo-substituted where the compounds of the formula (I) contain at least one anionic radical from the group of sulfo and carboxyl having the countercation M.sup.+, where M.sup.+ is an alkali metal cation or an organic cation.

The compounds of the formula (I) are especially suitable for use in color filters.

Provided are a novel pyridine carboxylic acid based compound used as a P2X.sub.1 and P2X.sub.3 receptor antagonist, a production method for the same and a composition comprising the same. The compound according to the present invention is a powerful antagonist of P2X.sub.1 and P2X.sub.3 receptors, and hence can be used as a drug for treating or preventing diseases involving neurological pain or chronic inflammatory diseases which are diseases caused by P2X.sub.1 and P2X.sub.3 receptor activity.

Provided are a novel pyridine carboxylic acid based compound used as a P2X.sub.1 and P2X.sub.3 receptor antagonist, a production method for the same and a composition comprising the same. The compound according to the present invention is a powerful antagonist of P2X.sub.1 and P2X.sub.3 receptors, and hence can be used as a drug for treating or preventing diseases involving neurological pain or chronic inflammatory diseases which are diseases caused by P2X.sub.1 and P2X.sub.3 receptor activity.

The present invention discloses a process for the preparation of substituted pyridine compounds of formula (I), comprises a step in which vinylogous nitriles of formula (II), are obtained from substituted ,-unsaturated nitrile compounds of formula (III), and a further step of converting the vinylogous nitrile compounds of formula (II) into substituted pyridines of formula (I); wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and LG are as defined in the description. ##STR00001##