The present application relates to processes for the preparation of quinolone compounds and intermediates thereof, particularly to processes for the preparation of quinolones and pharmaceutical intermediates of the quinolones. In particular, the present application provides a process for the preparation of a compound of Formula I, and a process for the synthesis of quinolone compounds using the compound of Formula I as an intermediate. The process for the preparation of the compound of Formula I comprises the steps of: reacting a compound of Formula A with R.sup.5NH.sub.2 and R.sup.6Cl in the presence of a base to form the compound of Formula I, ##STR00001##

Novel compounds and methods of killing or inhibiting the growth of bacteria.

Novel compounds and methods of killing or inhibiting the growth of bacteria.

An object of the present invention is to provide a cMLCK activator that can enhance myocardial contractility without an increase in cellular calcium concentration. This object is achieved by a cMLCK activator containing an 8-hydroxyquinoline compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof, or a solvate thereof,

##STR00001## wherein R.sup.1 represents hydrogen or the like; R.sup.2 represents R.sup.7CO (R.sup.7 is C.sub.1-6 alkyl or the like) or the like; R.sup.3 represents hydrogen; and R.sup.4, R.sup.5, and R.sup.6 represent hydrogen or the like.

An object of the present invention is to provide a cMLCK activator that can enhance myocardial contractility without an increase in cellular calcium concentration. This object is achieved by a cMLCK activator containing an 8-hydroxyquinoline compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof, or a solvate thereof,

##STR00001## wherein R.sup.1 represents hydrogen or the like; R.sup.2 represents R.sup.7CO (R.sup.7 is C.sub.1-6 alkyl or the like) or the like; R.sup.3 represents hydrogen; and R.sup.4, R.sup.5, and R.sup.6 represent hydrogen or the like.