Patent classifications
C07D231/50
PYRAZOLE DERIVATIVES USEFUL AS 5-LIPOXYGENASE ACTIVATING PROTEIN (FLAP) INHIBITORS
The present application relates to novel compounds of formula (I) to their utility in treating and/or preventing clinical conditions including cardiovascular diseases (CVD), to methods for their therapeutic use, to pharmaceutical compositions containing them and to processes for preparing such compounds.
##STR00001##
N-SUBSTITUTED HYDROXAMIC ACIDS WITH CARBON-BASED LEAVING GROUPS AS EFFICIENT HNO DONORS AND USES THEREOF
N-substituted hydroxamic acids with carbon-based leaving groups as efficient HNO donors are disclosed. Pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions also are disclosed.
AMINOPYRAZOLONE DERIVATIVE
The present invention is intended to provide a compound or a pharmacologically acceptable salt thereof which has an excellent inhibitory action on the ATPase activity of a TIP48/TIP49 complex and as such, is useful for the treatment of tumors.
[Solution]
The present invention provides a compound having a structure represented by the general formula (I) or a pharmacologically acceptable salt thereof, and a pharmaceutical composition comprising the compound. In the formula, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, and W are as defined in the present specification.
AMINOPYRAZOLONE DERIVATIVE
The present invention is intended to provide a compound or a pharmacologically acceptable salt thereof which has an excellent inhibitory action on the ATPase activity of a TIP48/TIP49 complex and as such, is useful for the treatment of tumors.
[Solution]
The present invention provides a compound having a structure represented by the general formula (I) or a pharmacologically acceptable salt thereof, and a pharmaceutical composition comprising the compound. In the formula, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, and W are as defined in the present specification.
PAINT THINNER FORMULATION
The present invention provides a paint thinner formulation that comprises an aliphatic hydrocarbon, an aromatic hydrocarbon, an alcohol and a solvency promotor. The paint thinner formulation of the present invention comprises an aliphatic hydrocarbon, an aromatic hydrocarbon, an alcohol and a solvency promotor comprising a compound of formula (3).
PAINT THINNER FORMULATION
The present invention provides a paint thinner formulation that comprises an aliphatic hydrocarbon, an aromatic hydrocarbon, an alcohol and a solvency promotor. The paint thinner formulation of the present invention comprises an aliphatic hydrocarbon, an aromatic hydrocarbon, an alcohol and a solvency promotor comprising a compound of formula (3).
Pyrazolone formyl peptide 2 receptor agonists
The disclosure relates to compounds of formula I, which are formyl peptide 2 (FPR2) receptor agonists. The disclosure also provides compositions and methods of using the compounds, for example, for the treatment of atherosclerosis, heart failure, chronic obstructive pulmonary disease (COPD), and related diseases. ##STR00001##
Pyrazolone formyl peptide 2 receptor agonists
The disclosure relates to compounds of formula I, which are formyl peptide 2 (FPR2) receptor agonists. The disclosure also provides compositions and methods of using the compounds, for example, for the treatment of atherosclerosis, heart failure, chronic obstructive pulmonary disease (COPD), and related diseases. ##STR00001##