C07D239/66

C-Rel inhibitors and uses thereof

Compounds having a c-Rel inhibiting property according to the formula: (1) wherein R.sup.1 and R.sup.2 are each independently selected from hydrogen atom and hydrocarbon groups having at least one and up to thirty carbon atoms and optionally substituted with one or more heteroatoms selected from halogen, nitrogen, oxygen, and sulfur; R.sup.3 is selected from hydrocarbon groups having at least one and up to thirty carbon atoms and optionally substituted with one or more heteroatoms selected from halogen, nitrogen, oxygen, and sulfur; and X.sup.1, X.sup.2, and X.sup.3 are each independently selected from oxygen and sulfur atoms. Methods for treating diseases and conditions associated with c-Rel overexpression by administering compounds of Formula (1) or a pharmaceutical composition thereof to a subject afflicted with such a disease or condition are also described. ##STR00001##

C-Rel inhibitors and uses thereof

Compounds having a c-Rel inhibiting property according to the formula: (1) wherein R.sup.1 and R.sup.2 are each independently selected from hydrogen atom and hydrocarbon groups having at least one and up to thirty carbon atoms and optionally substituted with one or more heteroatoms selected from halogen, nitrogen, oxygen, and sulfur; R.sup.3 is selected from hydrocarbon groups having at least one and up to thirty carbon atoms and optionally substituted with one or more heteroatoms selected from halogen, nitrogen, oxygen, and sulfur; and X.sup.1, X.sup.2, and X.sup.3 are each independently selected from oxygen and sulfur atoms. Methods for treating diseases and conditions associated with c-Rel overexpression by administering compounds of Formula (1) or a pharmaceutical composition thereof to a subject afflicted with such a disease or condition are also described. ##STR00001##

Bifunctional Compounds and Use for Reducing Uric Acid Levels
20170197923 · 2017-07-13 ·

Bifunctional compounds that increase uric acid excretion and reduce uric acid production. Methods of using these compounds for reducing uric acid levels in blood or serum, for treating disorders or uric acid metabolism, and for maintaining normal uric acid levels in blood or serum are provided. Pharmaceutical compositions comprising the bifunctional compounds are also provided.

Compound, hole transport material, and photoelectric conversion element including same

An object of the present invention is to provide a compound that is useful as a hole transport material for providing a device for converting light into electricity that is capable of extracting current with high efficiency, and a device for converting light into electricity and a solar cell that include the compound in a hole transport layer and have favorable light/electricity conversion characteristics. The present invention provides a compound represented by the general formula (1) below. In the formula, R.sup.1 to R.sup.20 each represent a hydrogen atom, an alkoxy group having 1 to 20 carbon atoms, or the like, and Y represents an oxygen atom or CR.sup.21R.sup.22, where R.sup.21 and R.sup.22 each represent a nitrile group, an acyl group having 1 to 10 carbon atoms, or the like. ##STR00001##

Compound, hole transport material, and photoelectric conversion element including same

An object of the present invention is to provide a compound that is useful as a hole transport material for providing a device for converting light into electricity that is capable of extracting current with high efficiency, and a device for converting light into electricity and a solar cell that include the compound in a hole transport layer and have favorable light/electricity conversion characteristics. The present invention provides a compound represented by the general formula (1) below. In the formula, R.sup.1 to R.sup.20 each represent a hydrogen atom, an alkoxy group having 1 to 20 carbon atoms, or the like, and Y represents an oxygen atom or CR.sup.21R.sup.22, where R.sup.21 and R.sup.22 each represent a nitrile group, an acyl group having 1 to 10 carbon atoms, or the like. ##STR00001##