The present disclosure compounds, as well as their compositions and methods of use. The compounds inhibit the activity of the TEAD transcription factor, and are useful in the treatment of diseases related to the activity of TEAD transcription factor including, e.g., cancer and other diseases.

The present invention provides methods for the purification of the compound of Formula (I) from the precipitated reaction product comprising the compound of Formula (I), impurities, and/or residual or entrained solvents.

Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as pesticides, and especially fungicides.

##STR00001##

Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as pesticides, and especially fungicides.

##STR00001##

The present invention provides compounds useful in treating or preventing inflammation, acne, bacterial conditions and promoting the appearance of healthy skin and compositions including these compounds.

The present invention provides compounds useful in treating or preventing inflammation, acne, bacterial conditions and promoting the appearance of healthy skin and compositions including these compounds.

An object of the present invention is to provide a compound useful as an anti-tumor agent or the like; an intermediate thereof; and a pharmaceutical composition, an anti-tumor agent, and a dihydroorotate dehydrogenase inhibitor, each of which contains the compound. According to the present invention, there is provided a compound represented by General Formula (1) or a salt thereof:

##STR00001## in the formula, Z.sup.1, Z.sup.2, and Z.sup.3 are the same as or different from each other and represent a nitrogen atom or CH; Z.sup.4 represents a nitrogen atom or a general formula of CR.sup.6; Z.sup.5 represents a nitrogen atom or a general formula of CR.sup.7 provided that at least one of Z.sup.1, Z.sup.2, Z.sup.3, Z.sup.4, or Z.sup.5 represents a nitrogen atom; R.sup.1 represents a general formula of CONHR.sup.8 or the like; R.sup.2 represents a C.sub.3-8 cycloalkyl group which may be substituted or the like; R.sup.3, R.sup.5, R.sup.6, and R.sup.7 are the same as or different from each other and represent a hydrogen atom, a halogen atom, or the like; R.sup.4 represents an aryl group which may be substituted or a heterocyclic group which may be substituted; R.sup.8 represents a general formula of SO.sub.2R.sup.9 or the like; and R.sup.9 represents an amino group which may be protected or the like.

An object of the present invention is to provide a compound useful as an anti-tumor agent or the like; an intermediate thereof; and a pharmaceutical composition, an anti-tumor agent, and a dihydroorotate dehydrogenase inhibitor, each of which contains the compound. According to the present invention, there is provided a compound represented by General Formula (1) or a salt thereof:

##STR00001## in the formula, Z.sup.1, Z.sup.2, and Z.sup.3 are the same as or different from each other and represent a nitrogen atom or CH; Z.sup.4 represents a nitrogen atom or a general formula of CR.sup.6; Z.sup.5 represents a nitrogen atom or a general formula of CR.sup.7 provided that at least one of Z.sup.1, Z.sup.2, Z.sup.3, Z.sup.4, or Z.sup.5 represents a nitrogen atom; R.sup.1 represents a general formula of CONHR.sup.8 or the like; R.sup.2 represents a C.sub.3-8 cycloalkyl group which may be substituted or the like; R.sup.3, R.sup.5, R.sup.6, and R.sup.7 are the same as or different from each other and represent a hydrogen atom, a halogen atom, or the like; R.sup.4 represents an aryl group which may be substituted or a heterocyclic group which may be substituted; R.sup.8 represents a general formula of SO.sub.2R.sup.9 or the like; and R.sup.9 represents an amino group which may be protected or the like.

Disclosed herein is a two-piece sensor assembly that includes an attachment collar configured to attach to a body surface of a patient and comprising at least one opening, and a skin sensor configured to seat into the at least one opening in the attachment collar. The skin sensor includes at least one radiation source configured to irradiate the body surface with at least one interrogation light, and at least one detector configured to detect at least one response light incident from the direction of the body surface.

Disclosed herein is a two-piece sensor assembly that includes an attachment collar configured to attach to a body surface of a patient and comprising at least one opening, and a skin sensor configured to seat into the at least one opening in the attachment collar. The skin sensor includes at least one radiation source configured to irradiate the body surface with at least one interrogation light, and at least one detector configured to detect at least one response light incident from the direction of the body surface.