Patent classifications
C07D251/44
Triazine derivatives as differentiation catalysts
A method of inducing differentiation of mammalian cells into cardiomyocyte-like cells by contacting the mammalian cell with a triazine compound of formula (I), wherein X is independently NR.sub.4or O, R.sub.4 is hydrogen or C.sub.1-6-alkyl; R.sub.1 is hydroxy, C.sub.1-6-alkyl, C.sub.1-6-alkoxy, carboxy, C.sub.1-6-alkoxycarbonyl, halo, cyano, nitro, formyl, amino, C.sub.1-6-alkylamino, or di-C.sub.1-6-alkylamino, the C.sub.1-6-alkyl or -alkoxy residue being optionally substituted with one or more R.sub.5 substituents selected from hydroxy, halo, cyano, and nitro; n is 0 to 5; R.sub.2 is hydrogen, aryl, heteroaryl, or C.sub.1-6-alkyl, the aryl or heteroaryl residue being optionally substituted with one or more R.sub.1 substituents, and where the C.sub.1-6-alkyl is optionally further substituted with one or more R.sub.5 substituents; and R.sub.3 is selected from hydrogen, halo, NR.sub.4R.sub.7, OR.sub.7, SR.sub.7, and R.sub.7, where the same options apply for R.sub.7 as for R.sub.2; with the proviso that the compound of formula (I) is not 3-[(4,6-diphenoxy-1,3,5-triazin-2-yl)amino]benzoic acid.