A process for preparing a triazine-based precursor for producing a micro-particulate complex containing a far infrared-emissive silica particle comprises steps of: a) subjecting 2-4-6-trichloro-1,3,5-triazine and a first nucleophilic compound to a displacement reaction in the presence of a first solvent at a first temperature range to form an intermediate; and b) subjecting the intermediate and a second nucleophilic compound to a further displacement reaction in the presence of a second solvent at a second temperature range higher than the first temperature range.

A method for stabilization of collagen matrices and of condensation of natural and synthetic polymers that uses 2-halo-4, 6-dialkoxy-1, 3, 5-triazines in the presence of one or more amines as activating agents for reactions of crosslinking, condensation, grafting, and curing of collagen matrices, cellulose, modified celluloses, polysaccharides, acid unsaturated polymers, and chiral and non-chiral amines, etc. Forming an integral part of the present invention is also the method for production on an industrial scale of 2-halo-4, 6-dialkoxy-1, 3, 5-triazines.

A method for stabilization of collagen matrices and of condensation of natural and synthetic polymers that uses 2-halo-4, 6-dialkoxy-1, 3, 5-triazines in the presence of one or more amines as activating agents for reactions of crosslinking, condensation, grafting, and curing of collagen matrices, cellulose, modified celluloses, polysaccharides, acid unsaturated polymers, and chiral and non-chiral amines, etc. Forming an integral part of the present invention is also the method for production on an industrial scale of 2-halo-4, 6-dialkoxy-1, 3, 5-triazines.

A compound (A) is represented by the formula (1):

##STR00001## wherein R.sup.1 is a hydrogen atom or an alkali metal atom, R.sup.2 is a hydrogen atom or an alkali metal atom, R.sup.3 is a hydrogen atom or a methyl group, Z is a divalent or trivalent organic group, and the lines consisting of a solid line and a broken line bonded to Z represent a single bond or a double bond.

A compound (A) is represented by the formula (1):

##STR00001## wherein R.sup.1 is a hydrogen atom or an alkali metal atom, R.sup.2 is a hydrogen atom or an alkali metal atom, R.sup.3 is a hydrogen atom or a methyl group, Z is a divalent or trivalent organic group, and the lines consisting of a solid line and a broken line bonded to Z represent a single bond or a double bond.

A polyether group-containing compound of the formula (I). In each of the compound of the formula (I), one or two R— are represented by (Rf—X.sup.f1-PE-X.sup.f2).sub.α—X.sup.1—, and one or two R— are represented by R.sup.Si—. The symbols are as defined in the description.

##STR00001##

A polyether group-containing compound of the formula (I). In each of the compound of the formula (I), one or two R— are represented by (Rf—X.sup.f1-PE-X.sup.f2).sub.α—X.sup.1—, and one or two R— are represented by R.sup.Si—. The symbols are as defined in the description.

##STR00001##

The disclosure relates to aryl hydrocarbon receptor antagonists as well as methods of modulating aryl hydrocarbon receptor activity and expanding hematopoietic stem cells by culturing hematopoietic stem or progenitor cells in the presence of these agents. Additionally, the disclosure provides methods of treating various pathologies, such as cancer, by administration of these aryl hydrocarbon receptor antagonists. Additionally, the disclosure provides methods of treating various pathologies in a patient by administration of expanded hematopoietic stem cells. The disclosure further provides kits containing aryl hydrocarbon receptor antagonists that can be used for the expansion of hematopoietic stem cells. The disclosure further relates to pharmaceutical compositions comprising the compounds and methods of treating or preventing a disease in which aryl hydrocarbon receptor plays a role.

A compound (A) is represented by the formula (1): ##STR00001## wherein R.sup.1 is a hydrogen atom or an alkali metal atom, R.sup.2 is a hydrogen atom or an alkali metal atom, R.sup.3 is a hydrogen atom or a methyl group, Z is a divalent or trivalent organic group, and the lines consisting of a solid line and a broken line bonded to Z represent a single bond or a double bond.

A compound (A) is represented by the formula (1): ##STR00001## wherein R.sup.1 is a hydrogen atom or an alkali metal atom, R.sup.2 is a hydrogen atom or an alkali metal atom, R.sup.3 is a hydrogen atom or a methyl group, Z is a divalent or trivalent organic group, and the lines consisting of a solid line and a broken line bonded to Z represent a single bond or a double bond.