The present invention provides a novel P2X.sub.3 and/or P2X.sub.2/3 receptor antagonist. A compound represented by the formula (I): ##STR00001##
wherein R.sup.a, R.sup.b and R.sup.c are, (a) R.sup.a and R.sup.b are taken together Z; and R.sup.c is a group represented by R.sup.1c; or (b) R.sup.b and R.sup.c are taken together to form a bond; and R.sup.a is a group represented by YR.sup.1a; R.sup.1a and R.sup.1c are each independently hydrogen, substituted or unsubstituted alkyl, etc.; R.sup.2 and R.sup.3 are each independently substituted or unsubstituted aryl, etc.; R.sup.4a and R.sup.4b are each independently hydrogen, substituted or unsubstituted alkyl, etc.; X is N(R.sup.5), etc.; R.sup.5 is hydrogen, substituted or unsubstituted lower alkyl, etc.; Y is O, etc.; Z is O, etc.; and n is an integer of 0 to 4.

Provided are methods and compositions for treating cancers in patients carrying an IDH1 mutation or IDH2 mutation.

Compounds of Formula I, including pharmaceutically acceptable salts thereof, are set forth, in addition to compositions and methods of using these compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

Compounds of Formula I, including pharmaceutically acceptable salts thereof, are set forth, in addition to compositions and methods of using these compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

The present invention relates to the field of HIV-1 infections, and in particular provides novel compounds containing triazine rings and suitable spacers. The compounds according to this invention are very suitable for the prevention and/or treatment of HIV-1 infection and in particular show improved activity against NNRTI-resistant viruses of HIV-1.

The present invention relates to the field of HIV-1 infections, and in particular provides novel compounds containing triazine rings and suitable spacers. The compounds according to this invention are very suitable for the prevention and/or treatment of HIV-1 infection and in particular show improved activity against NNRTI-resistant viruses of HIV-1.

Compounds of Formula I, including pharmaceutically acceptable salts thereof, are set forth, in addition to compositions and methods of using these compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV. ##STR00001##

Compounds of Formula I, including pharmaceutically acceptable salts thereof, are set forth, in addition to compositions and methods of using these compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV. ##STR00001##

The present invention relates to diaminotriazine compounds of the formula (I) and to their use as herbicides. The present invention also relates to agrochemical compositions for crop protection and to a method for controlling unwanted vegetation.

##STR00001## wherein A is phenyl, which is substituted by fluorine in the ortho-position and which may additionally carry 1, 2, 3 or 4 identical or different substituents R.sup.A; R.sup.1, R.sup.2 are inter alia H, OH, S(O).sub.2NH.sub.2, ON, C.sub.1-C.sub.6-alkyl, C.sub.2-C.sub.6-alkenyl, C.sub.2-C.sub.6-alkynyl, (C.sub.3-C.sub.6-cycloalkyl)-C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.6-alkoxy, (C.sub.1-C.sub.6-alkoxy)-C.sub.1-C.sub.6-alkyl, (C.sub.1-C.sub.6-alkyl)-carbonyl, (C.sub.1-C.sub.6-alkoxy)carbonyl, (C.sub.1-C.sub.6-alkyl)sulfonyl, (C.sub.1-C.sub.6-alkylamino)carbonyl, di(C.sub.1-C.sub.6-alkyl)aminocarbonyl, (C.sub.1-C.sub.6-alkylamino)sulfonyl, di(C.sub.1-C.sub.6-alkyl)aminosulfonyl and (C.sub.1-C.sub.6-alkoxy)sulfonyl, etc. X is NR.sup.3aR.sup.3b, OR.sup.3c or S(O).sub.kR.sup.3d, wherein R.sup.3a, R.sup.3b, R.sup.3c or R.sup.3d are independently of one another are selected from the group consisting of H, CN, S(O).sub.2NH.sub.2, C.sub.1-C.sub.6-alkyl, C.sub.2-C.sub.6-alkenyl, C.sub.2-C.sub.6-alkynyl, C.sub.3-C.sub.6-cycloalkyl, (C.sub.3-C.sub.6-cycloalkyl)-C.sub.1-C.sub.6-alkyl, (C.sub.1-C.sub.6-alkoxy)-C.sub.1-C.sub.6-alkyl, (C.sub.1-C.sub.6-alkyl)-carbonyl, (C.sub.1-C.sub.6-alkoxy)carbonyl, (C.sub.1-C.sub.6-alkyl)sulfonyl, C.sub.1-C.sub.6-alkylamino)carbonyl, di(C.sub.1-C.sub.6-alkyl)aminocarbonyl, (C.sub.1-C.sub.6-alkylamino)sulfonyl, di(C.sub.1-C.sub.6-alkyl)aminosulfonyl and (C.sub.1-C.sub.6-alkoxy)sulfonyl, etc. including their agriculturally acceptable salts.

The present invention relates to diaminotriazine compounds of the formula (I) and to their use as herbicides. The present invention also relates to agrochemical compositions for crop protection and to a method for controlling unwanted vegetation.

##STR00001## wherein A is phenyl, which is substituted by fluorine in the ortho-position and which may additionally carry 1, 2, 3 or 4 identical or different substituents R.sup.A; R.sup.1, R.sup.2 are inter alia H, OH, S(O).sub.2NH.sub.2, ON, C.sub.1-C.sub.6-alkyl, C.sub.2-C.sub.6-alkenyl, C.sub.2-C.sub.6-alkynyl, (C.sub.3-C.sub.6-cycloalkyl)-C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.6-alkoxy, (C.sub.1-C.sub.6-alkoxy)-C.sub.1-C.sub.6-alkyl, (C.sub.1-C.sub.6-alkyl)-carbonyl, (C.sub.1-C.sub.6-alkoxy)carbonyl, (C.sub.1-C.sub.6-alkyl)sulfonyl, (C.sub.1-C.sub.6-alkylamino)carbonyl, di(C.sub.1-C.sub.6-alkyl)aminocarbonyl, (C.sub.1-C.sub.6-alkylamino)sulfonyl, di(C.sub.1-C.sub.6-alkyl)aminosulfonyl and (C.sub.1-C.sub.6-alkoxy)sulfonyl, etc. X is NR.sup.3aR.sup.3b, OR.sup.3c or S(O).sub.kR.sup.3d, wherein R.sup.3a, R.sup.3b, R.sup.3c or R.sup.3d are independently of one another are selected from the group consisting of H, CN, S(O).sub.2NH.sub.2, C.sub.1-C.sub.6-alkyl, C.sub.2-C.sub.6-alkenyl, C.sub.2-C.sub.6-alkynyl, C.sub.3-C.sub.6-cycloalkyl, (C.sub.3-C.sub.6-cycloalkyl)-C.sub.1-C.sub.6-alkyl, (C.sub.1-C.sub.6-alkoxy)-C.sub.1-C.sub.6-alkyl, (C.sub.1-C.sub.6-alkyl)-carbonyl, (C.sub.1-C.sub.6-alkoxy)carbonyl, (C.sub.1-C.sub.6-alkyl)sulfonyl, C.sub.1-C.sub.6-alkylamino)carbonyl, di(C.sub.1-C.sub.6-alkyl)aminocarbonyl, (C.sub.1-C.sub.6-alkylamino)sulfonyl, di(C.sub.1-C.sub.6-alkyl)aminosulfonyl and (C.sub.1-C.sub.6-alkoxy)sulfonyl, etc. including their agriculturally acceptable salts.