Patent classifications
C07D279/26
USE OF PHENOTHIAZINE DERIVATIVE IN THE TREATMENT OF INFECTION CAUSED BY BACTERIA CARRYING TYPE IV PILI
The present invention provides a phenothiazine derivative of formula (I) for use in preventing and/or treating infection caused by bacteria carrying Type IV pili, such as N. meningitidis, and more specifically for use in preventing and/or treating meningitis. The present invention further relates to a composition for the use in preventing and/or treating infection caused by bacteria carrying Type IV pili, such as purpura fulminans and meningitis, comprising a phenothiazine derivative of formula (I) and an antibiotic selected from the group consisting of beta-lactams and aminoglycosides, and/or dexamethasone.
##STR00001##
THERMALLY ACTIVATED DELAYED FLUORESCENCE MATERIAL AND METHOD FOR PREPARING THEREOF AND ORGANIC ELECTROLUMINESCENT DIODE DEVICE
A thermally activated delayed fluorescent (TADF) compound, a method for preparing thereof, and an organic electroluminescent diode device are provided. The thermally activated delayed fluorescent compound includes a chemical structure of formula I:
##STR00001##
and R is an electron donating group. A trifluoromethyl group is used as a strong electron acceptor group, and an electron donor group is modified by combining different functional groups. An influence of the strength of the electron donor on material properties is researched to design a blue-light thermal activation delayed fluorescent compounds with significant TADF properties. The thermally activated delayed fluorescent compounds have a high reaction rate constant of reverse intersystem enthalpy constant (k.sub.RISC) and highly efficient blue-light TADF materials. When the thermally activated delayed fluorescent compounds are used as a light-emitting material for an organic light-emitting display device, and the organic light-emitting display device is improved to have high luminous efficiency.
THERMALLY ACTIVATED DELAYED FLUORESCENCE MATERIAL AND METHOD FOR PREPARING THEREOF AND ORGANIC ELECTROLUMINESCENT DIODE DEVICE
A thermally activated delayed fluorescent (TADF) compound, a method for preparing thereof, and an organic electroluminescent diode device are provided. The thermally activated delayed fluorescent compound includes a chemical structure of formula I:
##STR00001##
and R is an electron donating group. A trifluoromethyl group is used as a strong electron acceptor group, and an electron donor group is modified by combining different functional groups. An influence of the strength of the electron donor on material properties is researched to design a blue-light thermal activation delayed fluorescent compounds with significant TADF properties. The thermally activated delayed fluorescent compounds have a high reaction rate constant of reverse intersystem enthalpy constant (k.sub.RISC) and highly efficient blue-light TADF materials. When the thermally activated delayed fluorescent compounds are used as a light-emitting material for an organic light-emitting display device, and the organic light-emitting display device is improved to have high luminous efficiency.
COMPOSITION AND LIGHT EMITTING DEVICE USING THE SAME
A composition which is useful for producing a light emitting device having excellent external quantum efficiency contains two or more compounds represented by the formula (C-1) and a phosphorescent compound, in which at least one of the compounds represented by the formula (C-1) is a compound in which R.sup.C is a group represented by the formula (C-1).
##STR00001##
Ring R.sup.1C and Ring R.sup.2C represent an aromatic hydrocarbon ring or an aromatic hetero ring. R.sup.C represents an oxygen atom, a sulfur atom or a group represented by the formula (C-1).
##STR00002##
Ring R.sup.3C and Ring R.sup.4C represent an aromatic hydrocarbon ring or an aromatic hetero ring. R.sup.C represents a carbon atom, a silicon atom, a germanium atom, a tin atom or a lead atom.
COMPLEX CRYSTAL AND CHEMOSENSOR PROVIDED WITH SAME
The complex crystal of the present disclosure is a complex crystal having a structure in which supramolecular units each composed of two or more types of molecules are arrayed. Each of the supramolecular units contains a cyanoacrylic acid derivative and a trisubstituted methylamine as the molecules. The complex crystal has, between the supramolecular units, molecular cavities in each of which a guest molecule for which the supramolecular unit is a host is not disposed. The complex crystal of the present disclosure can have a property of incorporating a chemical substance therein and can exhibit a great change in a characteristic when incorporating the chemical substance therein.
SMALL MOLECULE BAX INHIBITORS AND USES THEREOF
Compounds, compositions and method of using these compounds are disclosed for treating a disease or disorder in which it is desirable to inhibit BAX, such as a cardiovascular disease or disorder.
Small molecule BAX inhibitors and uses thereof
Compounds, compositions and method of using these compounds are disclosed for treating a disease or disorder in which it is desirable to inhibit BAX, such as a cardiovascular disease or disorder.
Small molecule BAX inhibitors and uses thereof
Compounds, compositions and method of using these compounds are disclosed for treating a disease or disorder in which it is desirable to inhibit BAX, such as a cardiovascular disease or disorder.
HETEROCYCLIC COMPOUNDS AND THEIR USE IN ELECTRO-OPTICAL OR OPTO-ELECTRONIC DEVICES
Compounds exhibiting high hole mobility and/or high glass transition temperatures are provided which are of the formula [Ar.sup.1].sub.m[Ar.sup.2].sub.n wherein: m is an integer from 1-3 and n is an integer and may be 1 or 2; Ar.sup.1 represents a thianthrene residue having a linkage to Ar.sup.2 at one or two positions selected from ring positions 1-4 and 5-8 and optionally mono-, bi- or poly-substituted with C.sub.1-C.sub.4-alkyl-, C.sub.1-C.sub.4-alkoxy-, fluoro, phenyl or biphenyl which in the case of phenyl or biphenyl may be further substituted with C.sub.1-C.sub.4-alkyl-, C.sub.1-C.sub.4-alkoxy- or fluoro; Ar.sup.2 represents a residue derived from an arylamine in which the aryl rings are phenyl, naphthyl or anthracenyl optionally substituted with C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-alkoxy- or fluoro, a polycyclic fused or chain aromatic ring system optionally containing nitrogen or sulphur and in a chain aromatic ring system optionally containing one or more chain oxygen or sulphur atoms, a triarylphosphine oxide or an arylsilane the rings of any of which are optionally substituted with C.sub.1-C.sub.4-alkyl-, C.sub.1-C.sub.4-alkoxy- or fluoro.
Certain of the compounds may be used in electron transport layers and may be doped with p-type dopants. They may be incorporated into OLEDs, organic photovoltaic devices, imaging members and thin film transistors.
In further embodiments there are provided OLEDs or other devices e.g. electrostatic latent image forming members in which improved efficiency is obtained by using as electron transport layers, electron injectors, hosts and emitters (dopants) ambipolar or electron-transmitting compounds in which thianthrene is bonded to aryl e.g. 1-anthracenyl-9-yl-thianthrene, 1-biphenyl-4-yl-thianthrene and 9,10-Bis(1-thianthrenyl) anthracene.
Heterocyclic compounds and their use in electro-optical or opto-electronic devices
Compounds exhibiting high hole mobility and/or high glass transition temperatures are provided which are of the formula [Ar.sup.1].sub.m[Ar.sup.2].sub.n wherein: m is an integer from 1-3 and n is an integer and may be 1 or 2; Ar.sup.1 represents a thianthrene residue having a linkage to Ar.sup.2 at one or two positions selected from ring positions 1-4 and 5-8 and optionally mono-, bi- or poly-substituted with C.sub.1-C.sub.4-alkyl-, C.sub.1-C.sub.4-alkoxy-, fluoro, phenyl or biphenyl which in the case of phenyl or biphenyl may be further substituted with C.sub.1-C.sub.4-alkyl-, C.sub.1-C.sub.4-alkoxy- or fluoro; Ar.sup.2 represents a residue derived from an arylamine in which the aryl rings are phenyl, naphthyl or anthracenyl optionally substituted with C.sub.1-C.sub.4-alkyl-, C.sub.1-C.sub.4-alkoxy- or fluoro, a polycyclic fused or chain aromatic ring system optionally containing nitrogen or sulphur and in a chain aromatic ring system optionally containing one or more chain oxygen or sulphur atoms, a triarylphosphine oxide or an arylsilane the rings of any of which are optionally substituted with C.sub.1-C.sub.4-alkyl-, C.sub.1-C.sub.4-alkoxy- or fluoro. Certain of the compounds may be used in electron transport layers and may be doped with p-type dopants. They may be incorporated into OLEDs, organic photovoltaic devices, imaging members and thin film transistors. In further embodiments there are provided OLEDs or other devices e.g. electrostatic latent image forming members in which improved efficiency is obtained by using as electron transport layers, electron injectors, hosts and emitters (dopants) ambipolar or electron-transmitting compounds in which thianthrene is bonded to aryl e.g. 1-anthracenyl-9-yl-thianthrene, 1-biphenyl-4-yl-thianthrene and 9,10-Bis(1-thianthrenyl) anthracene.