Patent classifications
C07D285/135
Aryl hydrocarbon receptor (AHR) agonists and uses thereof
The present invention provides AHR agonists, compositions thereof, and methods of using the same.
Aryl hydrocarbon receptor (AHR) agonists and uses thereof
The present invention provides AHR agonists, compositions thereof, and methods of using the same.
Inhibitors of heat shock factors and uses thereof
The present disclosure relates to a class of mammalian heat shock factor (HSF) inhibitors, to pharmaceutical compositions comprising these inhibitors as well as to methods for using the inhibitors. The inhibitors inhibit stress-induced expression from heat shock gene promoters. Furthermore, the inhibitors are cytotoxic to a variety of human cancer cells types.
Inhibitors of heat shock factors and uses thereof
The present disclosure relates to a class of mammalian heat shock factor (HSF) inhibitors, to pharmaceutical compositions comprising these inhibitors as well as to methods for using the inhibitors. The inhibitors inhibit stress-induced expression from heat shock gene promoters. Furthermore, the inhibitors are cytotoxic to a variety of human cancer cells types.
Compounds which are inhibitors of Notum
A compound for use in the treatment of a disease ameliorated by the inhibition of Notum of formula (I): (I) ##STR00001##
Compounds which are inhibitors of Notum
A compound for use in the treatment of a disease ameliorated by the inhibition of Notum of formula (I): (I) ##STR00001##
HETEROCYCLIC INHIBITORS OF GLUTAMINASE
The invention relates to novel heterocyclic compounds and pharmaceutical preparations thereof. The invention further relates to methods of treatment using the novel heterocyclic compounds of the invention.
HETEROCYCLIC INHIBITORS OF GLUTAMINASE
The invention relates to novel heterocyclic compounds and pharmaceutical preparations thereof. The invention further relates to methods of treatment using the novel heterocyclic compounds of the invention.
POLYMERIZABLE COMPOUND AND OPTICALLY ANISOTROPIC BODY
A problem of the present invention is to provide a polymerizable compound and a polymerizable composition which cause little decrease in retardation and discoloration when a film-shaped polymer produced by polymerization is irradiated with ultraviolet/visible light for a long time at high temperature. A further problem is to provide a polymer produced by polymerizing the polymerizable composition and an optically anisotropic body using the polymer. As a result, a compound useful as a component of a polymerizable composition was obtained. An optically anisotropic body using a polymerizable liquid crystal composition containing the compound of the present invention is useful for application to an optical film and the like.
POLYMERIZABLE COMPOUND AND OPTICALLY ANISOTROPIC BODY
A problem of the present invention is to provide a polymerizable compound and a polymerizable composition which cause little decrease in retardation and discoloration when a film-shaped polymer produced by polymerization is irradiated with ultraviolet/visible light for a long time at high temperature. A further problem is to provide a polymer produced by polymerizing the polymerizable composition and an optically anisotropic body using the polymer. As a result, a compound useful as a component of a polymerizable composition was obtained. An optically anisotropic body using a polymerizable liquid crystal composition containing the compound of the present invention is useful for application to an optical film and the like.