Disclosed herein is an efficient, environment friendly and commercially viable process for preparation of chloromethylated compound of formula I in substantially pure form and high yield, from the compound of formula II. The process includes contacting the compound of formula II with a chloromethylating agent generated in-situ by reaction of a formaldehyde precursor and hydrogen chloride, in a suitable solvent/contacting medium and in the presence of a catalytic amount of a short chain/low molecular weight carboxylic acid of formula III. I II III wherein, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as defined in the description.

##STR00001##

Disclosed herein is an efficient, environment friendly and commercially viable process for preparation of chloromethylated compound of formula I in substantially pure form and high yield, from the compound of formula II. The process includes contacting the compound of formula II with a chloromethylating agent generated in-situ by reaction of a formaldehyde precursor and hydrogen chloride, in a suitable solvent/contacting medium and in the presence of a catalytic amount of a short chain/low molecular weight carboxylic acid of formula III. I II III wherein, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as defined in the description.

##STR00001##

A polymerizable liquid crystal composition capable of manufacturing an optically anisotropic film having excellent light fastness; and an optically anisotropic film, an optical film, a polarizing plate, an image display device, and an organic electroluminescent display device, each of which uses the polymerizable liquid crystal composition. The polymerizable liquid crystal composition of an embodiment of the present invention contains a polymerizable liquid crystal compound having reverse-wavelength dispersion properties and an aromatic polyether-based compound.

A polymerizable liquid crystal composition capable of manufacturing an optically anisotropic film having excellent light fastness; and an optically anisotropic film, an optical film, a polarizing plate, an image display device, and an organic electroluminescent display device, each of which uses the polymerizable liquid crystal composition. The polymerizable liquid crystal composition of an embodiment of the present invention contains a polymerizable liquid crystal compound having reverse-wavelength dispersion properties and an aromatic polyether-based compound.

The present invention provides a compound as represented by formula I, or a pharmaceutically acceptable salt or ester, a prodrug, an optical isomer, a stereoisomer, or a solvate thereof. The compound provided by the present invention can be used for preparing drugs for preventing or treating hypertension, or hypertension-related diseases, or pulmonary hypertension, or pulmonary hypertension-related diseases. The compound provided by the present invention has a different mechanism from existing drugs for treating hypertension and pulmonary hypertension, thereby laying a new material foundation for the development of drugs for treating hypertension and pulmonary hypertension.

##STR00001##

The present invention discloses compounds for inhibition of uncontrolled cell proliferation particularly cancer stem cells. Particularly, the invention relates to compounds of Formula I to XXII for the treatment of cancer.

The present invention discloses compounds for inhibition of uncontrolled cell proliferation particularly cancer stem cells. Particularly, the invention relates to compounds of Formula I to XXII for the treatment of cancer.

Disclosed in the present invention are a small molecule compound and use and a composition thereof. The use of the small molecule compound is specifically as follows: 4-((2-(4-(tert-butyl)phenoxy)acetyl)glycyl)phenyl benzo[d][1,3]dioxane-5-carboxylate, or a pharmaceutically, healthcare or food acceptable salt or ester or derivative thereof, or a mixture thereof for preparing substances for treating tumors, inhibiting tumor cell growth and/or inducing tumor cell apoptosis. The composition contains: (1) a compound 4-((2-(4-(tert-butyl)phenoxy)acetyl)glycyl)phenyl benzo[d][1,3]dioxane-5-carboxylate, or a pharmaceutically, healthcare or food acceptable salt or ester or derivative thereof, or a mixture thereof; (2) an apoptosis-causing drug; and (3) a pharmaceutically, healthcare or food acceptable carrier or excipient.

Disclosed in the present invention are a small molecule compound and use and a composition thereof. The use of the small molecule compound is specifically as follows: 4-((2-(4-(tert-butyl)phenoxy)acetyl)glycyl)phenyl benzo[d][1,3]dioxane-5-carboxylate, or a pharmaceutically, healthcare or food acceptable salt or ester or derivative thereof, or a mixture thereof for preparing substances for treating tumors, inhibiting tumor cell growth and/or inducing tumor cell apoptosis. The composition contains: (1) a compound 4-((2-(4-(tert-butyl)phenoxy)acetyl)glycyl)phenyl benzo[d][1,3]dioxane-5-carboxylate, or a pharmaceutically, healthcare or food acceptable salt or ester or derivative thereof, or a mixture thereof; (2) an apoptosis-causing drug; and (3) a pharmaceutically, healthcare or food acceptable carrier or excipient.

The present invention is directed to inhibitors of tyrosinase, pharmaceutical compositions comprising such tyrosinase inhibitors, and methods of making and using the same. Specifically, included in the present invention are compositions of matter comprised of at least one 2,4-dihydroxybenzene analog, which inhibit the activity of tyrosinase and which inhibit the overproduction of melanin.