C07F9/2466

METHODS AND COMPOSITIONS FOR ASSESSING CELL VIABILITY
20190195801 · 2019-06-27 ·

Provided herein are compounds, compositions, kits, uses, and methods for assessing the viability of cells and/or quantifying the amount of live and dead cells in a mixture using differential stains. In some embodiments, the compounds are used in culture media or can function independently of fixation and/or permeabilization. In some embodiments, the compounds comprise a platinum atom. In some embodiments, the compounds comprise a nitrogen mustard moiety.

PROCESS FOR RECOVERING A MIXTURE COMPRISING A (THIO)PHOSPHORIC ACID DERIVATIVE

Provided herein is a use of a high-boiling solvent in a mixture comprising a (thio)phosphoric acid derivative and a process including the addition of a high-boiling solvent to a mixture comprising a (thio)phosphoric acid derivative to recover the (thio)phosphoric acid from the mixture by an evaporation process.

DNA ALKYLATING AGENTS

Provided herein are compounds of formula I: wherein the variables are defined herein, processes of making them, and methods of treating cancer comprising administering such compounds.

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Compound containing structure of a heteroaromatic ring, pharmaceutical composition thereof and application thereof

Disclosed is a compound containing structure of a heteroaromatic ring, pharmaceutical composition thereof and application thereof. The present disclosure provides a compound containing structure of a heteroaromatic ring represented by formula I, a pharmaceutically acceptable salt thereof, a stereoisomer thereof, an isomer thereof or an isotopic compound thereof. The compound containing structure of a heteroaromatic ring is expected to treat and/or prevent various PARG-related diseases.

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