The invention provides a radically polymerizable compound wherein an acid group is joined via a spacer group to a polyethyleneimine group. The polyethyleneimine group has at least one radically polymerizable group in the side chain and/or terminally. The invention relates further to a process for preparing such compounds by cationic polymerization of oxazolines, to the use of such compounds as constituents of a dental material, and to a dental material comprising the compounds of the invention.

Oral dosage forms of osteoclast inhibitors, such as zoledronic acid, in an acid or a salt form can be used to treat or alleviate pain or related conditions, such as complex regional pain syndrome.

The present invention provides novel bisphosphonates vinylic monomers, polymers and particles that have utility as biologically active molecule (such as drugs) carriers, medical device coatings and for imaging/radiology applications, especially in bone and dental applications. The invention also provides methods of synthesizing the monomers, polymerizing the polymers, and assembling the particles of the invention.

A series of fluorine-containing bisphosphonic acids in which an alkylamine side chain is added, a series of fluorine-containing bisphosphonic acids in which an amino group substituted by a heterocyclic group or a heterocyclic group containing a nitrogen atom is added, to the carbon atom of PC(F)P, and a series of fluorine-containing bisphosphonate derivatives in which the acid moiety thereof is esterified by an alkoxymethyl group such as POM group, n-butanoyloxymethyl (BuOM) group and the like, that is, the fluorine-containing bisphosphonic acid and fluorine-containing bisphosphonate derivative represented by the following formula (I):

##STR00001##

wherein each symbol is as defined in the DESCRIPTION, can efficiently induce proliferation of peripheral blood T cells that express V2V2 T cell receptor having superior cytotoxicity against tumor cells and virus infected cells, immunize tumor cells and virus infected cells, and can induce cytotoxicity by T cells.

The present invention addresses uniformly formed layers on TCOs with minimized thickness which are hole transporting, due to a hole transport material which is configured for self assembly on the corresponding surface. The layers are formed by a compound made up of at least one kind of molecule according to formula (I) mixed up with a filler molecule FM given by ##STR00001##
where L is a linking fragment, A an anchor group and HTF is a hole transporting fragment. FM (filler molecule) is at least one kind of molecule consisting of an anchoring group, an alkyl chain of N carbon atoms, with N is in the range of 1 to 18, and a functional group of at least on of the group methyl, halogen, amino, bromide, ammonium and sulfuric functional group and where x is in the range of 0.02 to 1 and y equals (1x).

A multi-acid polymer has a multi-acid monomer with the following formula:

##STR00001##

wherein R is one or more units of a non-SOF.sub.2 or non-SO.sub.2Cl portion of a polymer precursor in sulfonyl fluoride or sulfonyl chloride form. Another multi-acid polymer has a multi-acid monomer with the following formula:

##STR00002##

wherein R is one or more units of a non-SOF.sub.2 or non-SO.sub.2Cl portion of a polymer precursor in sulfonyl fluoride or sulfonyl chloride form.

The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like.

The flame-retardants of this invention were formed by the direct reaction of ethyleneamines and commercial polyphosphoric acid at an elevated temperature. It was unexpected that a high temperature had to be used to overcome reaction barrier to formation. These compounds are found to be efficient flame retardants.

A method of making a multi-acid polymer comprising: reacting a polymer precursor in sulfonyl fluoride or sulfonyl chloride form with anhydrous ammonia to obtain a sulfonamide, wherein the polymer precursor in sulfonyl fluoride or sulfonyl chloride form has a formula RSO.sub.2F or RSO.sub.2Cl, respectively, with R being one of more units of the polymer precursor without sulfonyl fluoride or sulfonyl chloride, and wherein the sulfonamide has a formula RSO.sub.2NH.sub.2; and reacting the sulfonamide with a compound of a formula COOHX-AGG under a mild base condition, wherein X is one of C.sub.6H.sub.3 or N(CH.sub.2).sub.3 and AGG is an acid giving group, to form the multi-acid polymer having an imide base and more than two proton conducting groups.

Methods for the safe administration of imidazole or imidazolium compounds, and conditions that may be treated by these methods, are described herein.