The present technology is generally directed to adjustable shunting systems for draining fluid from a first body region to a second body region. The adjustable shunting systems include an actuation assembly for controlling the flow of fluid through the system. For example, the actuation assembly can include one or more fluid inlets in fluid communication with an environment external to the system. The actuation assembly can further include one or more actuators configured to move a corresponding control element to control the flow of fluid through the fluid inlets. The actuator can also have a first actuation element and a second actuation element configured to move the control element between a first position in which the control element substantially prevents fluid flow through the corresponding inlet and a second position in which the control element does not substantially prevent fluid flow through the fluid inlets.

It is proposed to provide and implantable tube valve for implanting in a urinary tract, comprising: an implantable tube; a valve member mounted inside the tube and pivotable between an open position and a closed position and an actuator for pivoting the valve member; wherein the valve member comprises a pivot part, said pivot part formed as a single beak part; said valve member provided with a safety mechanism including a biasing element, an actuator, and the pivot part, wherein the beak part is arranged to pivot the pivot part towards the open position when a pressure exerted on the beak part exceeds a predetermined pressure.

Devices are provided with an internal dimension that can be reduced and increased in vivo. In one example, an interatrial shunt for placement at an atrial septum of a patient's heart includes a body. The body includes first and second regions coupled in fluid communication by a neck region. The body includes a shape-memory material. The body defines a passageway through the neck region for blood to flow between a first atrium and a second atrium. The first and second regions are superelastic at body temperature, and the neck region is malleable at body temperature. A flow area of the passageway through the neck region may be adjusted in vivo.

Disclosed are systems and methods relating to an implant configured for reshaping a mitral valve. The implant comprises a plurality of struts with anchors for tissue engagement. The implant is compressible to a first, reduced diameter for transluminal or transapical navigation and delivery to the left atrium of a heart. The implant may then expand to a second, enlarged diameter to embed its anchors to the tissue surrounding and/or including the mitral valve. The size and/or shape of the implant may then be adjusted, pulling mitral annulus tissue radially inwardly, and restrained in the adjusted configuration to improve mitral valve function.

An implantation device includes an elongated tube having a first end portion, an opposing second end portion, and a third tapered portion connecting the first and second end portions. The first end portion includes a first opening and an angled tip. The second end portion includes a second opening, and the second end portion is wider than the first end portion. The implantation device also includes a rod inserted through the first opening and extending out of and away from the first end portion. The rod includes a tapered and rounded end. The second end portion is configured to receive a scleral prosthesis into the second opening and to release the scleral prosthesis from the second opening.

Excessive dilation of the annulus of a mitral valve may lead to regurgitation of blood during ventricular contraction. This regurgitation may lead to a reduction in cardiac output. Disclosed are systems and methods relating to an implant configured for reshaping a mitral valve. The implant comprises a plurality of struts with anchors for tissue engagement. The implant is compressible to a first, reduced diameter for transluminal navigation and delivery to the left atrium of a heart. The implant may then expand to a second, enlarged diameter to embed its anchors to the tissue surrounding and/or including the mitral valve. The implant may then contract to a third, intermediate diameter, pulling the tissue radially inwardly, thereby reducing the mitral valve and lessening any of the associated symptoms including mitral regurgitation.

A support structure for a three-sided scallop in the edge of a stent graft including two substantially longitudinal perimeter support sections and an undulating lateral side base extending between the two support sections. The undulations extend below the edge of the lateral side of the scallop and overlap the graft material away from the edge of the lateral side.

Devices are provided with an internal dimension that can be reduced and increased in vivo. In one example, an interatrial shunt for placement at an atrial septum of a patient's heart includes a body. The body includes first and second regions coupled in fluid communication by a neck region. The body includes a shape-memory material. The body defines a passageway through the neck region for blood to flow between a first atrium and a second atrium. The first and second regions are superelastic at body temperature, and the neck region is malleable at body temperature. A flow area of the passageway through the neck region may be adjusted in vivo.

A prosthetic heart valve comprises a collapsible and expandable support frame comprising a longitudinal axis. The frame comprises a first circumferential undulating structure defining an outflow end of the frame, and a second circumferential undulating structure spaced apart from the first circumferential undulating structure. The frame also comprises a plurality of struts longitudinally aligned with the longitudinal axis of the frame, and connecting the first circumferential undulating structure to the second circumferential undulating structure. Each strut of the plurality of struts comprises a first end terminating at a trough of the first circumferential undulating structure, and a second end terminating at a peak of the second circumferential undulating structure. The prosthetic heat valve also comprises a biological tissue valve coupled to the frame. The prosthetic heart valve is configured to be collapsed for introduction into a patient using a catheter and to be expanded for deployment at an implantation site.

Disclosed herein are esophageal sleeve devices comprising bioresorbable scaffolds having a first shape and a second shape. The bioresorbable scaffolds can be made from a shape memory polymer comprising at least one monomer unit of glycerol and at least one monomer unit of dodecanedioate. The bioresorbable scaffolds can also have a functionalized surface modified to have a biology corresponding to a patient. The bioresorbable scaffolds can take the first shape at a first environmental temperature and the second shape at a second environmental temperature. the second environmental temperature being greater than the first environmental temperature. Also disclosed herein are methods of implanting the same.