A prosthetic heart valve can include a support structure, an actuator member, and a plurality of leaflets. The support structure can have a plurality of struts and a plurality of rivets. The struts can have openings formed therein. The rivets can have first portions and second portions. The first portions can extend through the openings of the struts, and the second portions are larger than the first portion and the openings of the struts. The struts are pivotable about the rivets to radially expand and compress the support structure. The actuator member can be coupled to the struts of the support structure and configured to selectively actuate expansion and compression of the support structure. The leaflets can be coupled to the support structure and configured to allow unidirectional blood flow through the prosthetic heart valve.

A method of generating a patient-specific prosthetic includes receiving anatomic imaging data representative of a portion of a patient's anatomy. A first digital representation of the anatomic imaging data is defined. The first digital representation of the anatomic imaging data is modified. A second digital representation of the portion of the patient's anatomy is defined based on the modifying of the first digital representation of the anatomic imaging data. A patient-specific prosthetic template of the portion of the patient's anatomy is generated based at least in part on the second digital representation of the anatomic imaging data.

Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick, structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided.

A method and apparatus is provided for creating an internal reconstruction tissue graft. Templates may be used to create a multitude of patterns in a variety of tissue reconstruction grafts. An apparatus may be used to create an internal tissue graft for reconstruction through either compression and/or removal of segments. An apparatus may be used, through either compression and or removal of segments of a preformed template made of synthetics and or metal that mirrors a template that can be used as an internal tissue graft for reconstruction. In a method, such as using software analysis and an apparatus, the physical properties of the tissue graft and its pre- and post-operative properties and appearance may be measured.

A support structure includes strut members interconnected by articulated joints to form a series of linked scissor mechanisms. The structure can be remotely actuated to compress or expand its shape by adjusting the scissor joints within a range of motion. In particular, the support structure can be repositioned within the body lumen or retrieved from the lumen. The support structure can be employed to introduce and support a prosthetic valve within a body lumen.

A template 13 comprises a cusp base forming part 11 having a shape corresponding to a cusp base is provided to obtain cusp material for dispersing stresses exerted on the cusp. Such a cusp forming template may further comprise wing forming parts 15 corresponding to wing parts provided outside the cusp base forming part 11. As examples of the wing forming part, there may be employed a single or plural holes provided at a part or parts corresponding to the outline of each wing, and guide parts provided at parts corresponding to the outline of wings.

The present disclosure provides devices, systems, and methods relating to performing a medical procedure. In particular, the present disclosure is directed to devices, systems, and methods for accurately positioning and securing a body implant in a subject. A template corresponds to the implant, and the template is configured to mark a desired location in a patient prior to positioning the implant at the desired location.

This invention provides for the fabrication of ophthalmic lenses via the utilization of DMD shows and/or DMD files. More specifically, the use of the DMD shows and/or DMD files to generate lens precursor designs comprising described features to form part of a substructure for the fluid reactive media portion of the lens precursor and wherein the lens precursor can generate particular ophthalmic lens designs in a free-form manner using methods described herein.

This invention provides for the fabrication of ophthalmic lenses via the utilization of DMD shows and/or DMD files. More specifically, the use of the DMD shows and/or DMD files to generate lens precursor designs comprising described features to form part of a substructure for the fluid reactive media portion of the lens precursor and wherein the lens precursor can generate particular ophthalmic lens designs in a free-form manner using methods described herein.

A mandrel for molding polymer valve leaflets for heart valve prostheses is disclosed, including a body portion including an outer surface with ridges and contoured surfaces corresponding to the leaflets, the upper edge of the contoured surfaces corresponding to the free upper edge of the leaflets, and the mandrel including a mandrel extension above the body portion, and a gap extending around the mandrel between the upper edge of the contoured surface and the mandrel extension. A process for producing these polymer valve leaflets is also disclosed by dip coating with this mandrel and removing the polymer film created at the gap, preferably by applying suction or blowing thereto.