The present invention relates to an improved method for preparing a high purity polyethylene glycol dialdehyde derivative. The preparation method can provide the polyethylene glycol dialdehyde derivative suitable as a raw material for pharmaceuticals because of high purity and terminal activity, by using PEG-diacetal, which is prepared by reacting polyethyleneglycol methanesulfonate with dialkoxy-1-propanol, as an intermediate.

Provided are a polyol glyceryl ether, and a multi-armed polyethylene glycol and the multi-armed polyethylene glycol active derivative prepared using the same. The multi-armed polyethylene glycol is formed by polymerizing ethylene oxide with the polyol glyceryl ether as an initiator, and has the structure of general formula II, wherein B is a polyol group, n is an integer between 3 and 22, PEG is the same or not the same (OCH.sub.2CH.sub.2).sub.m, and the average value of m is an integer between 3 and 250. The multi-armed polyethylene glycol has a relatively low poly-dispersity and a relatively high determined molecular weight. Also provided is a conjugate of the multi-armed polyethylene glycol active derivative and pharmaceutical molecules, a pharmaceutical composition comprising the conjugate, and a gel formed by the multi-armed polyethylene glycol active derivative. The gel can be used to prepare a sustained-release drug for prolonging the time of the drug action.

The present invention relates to an amino polymer, its main chain is attached via a O group to a structure represented by the following formula (I). The present invention also relates to a process for producing said amino polymer and to its use as fuel oil detergent. Compared with the prior art, the fuel oil detergent of the present invention has the advantages such as a lower manufacturing cost and an improved deposit formation inhibition performance.

##STR00001##

In formula (I), groups and values are defined as described in the description.

Disclosed is a Y-type discrete polyethylene glycol derivative as shown by Formula (I). The Y-type discrete polyethylene glycol derivative has the advantages of a determined molecular weight and number of segments in the chain, and can avoid the defects where the polyethylene glycol derivative itself is a mixture and the molecular weight is not homogeneous. The Y-type polyethylene glycol of the present invention can solve the problem of insufficient water solubility caused by an increase in the loading capacity when the discrete polyethylene glycol modifies an insoluble drug while increasing the drug loading capacity.

##STR00001##

The present invention relates to (per)fluoropolyether (PFPE) amnino derivatives, a method for their manufacturing and their uses.

A branched hetero polyethylene glycol according to the present invention is represented by the formula [1]:

##STR00001##

wherein X and Y represent each an atomic group containing at least a functional group which reacts with a functional group present in a bio-functional molecule to form a covalent bond and the functional group contained in the atomic group X and the functional group contained in the atomic group Y are different from each other; s is an integer of 2 to 8, which represents the number of polyethylene glycol chains; n is the number of average added moles for the polyethylene glycol chain and 20n2000; and E is a branching linker moiety having s-valent bonding valency for the polyethylene glycol chains and having monovalent bonding valency for the functional group Y.

A branched hetero polyethylene glycol according to the present invention is represented by the formula [1]: ##STR00001##
wherein X and Y represent each an atomic group containing at least a functional group which reacts with a functional group present in a bio-functional molecule to form a covalent bond and the functional group contained in the atomic group X and the functional group contained in the atomic group Y are different from each other; s is an integer of 2 to 8, which represents the number of polyethylene glycol chains; n is the number of average added moles for the polyethylene glycol chain and 20n2000; and E is a branching linker moiety having s-valent bonding valency for the polyethylene glycol chains and having monovalent bonding valency for the functional group Y.

A polyalkylene ether glycol composition including a polyalkylene ether glycol including an alkoxy group serving as a terminal group. The polyalkylene ether glycol composition has a hydroxyl value of 220 or more and 750 or less. The ratio of the number of alkoxy group terminals of the polyalkylene ether glycol included in the polyalkylene ether glycol composition to the number of hydroxyl group terminals of polyalkylene ether glycols included in the polyalkylene ether glycol composition is 0.00001 or more and 0.0040 or less. Provided is a polyalkylene ether glycol composition having excellent compatibility with low-molecular-weight polyols, having suitable reactivity when used as a raw material for polyurethanes, and capable of achieving intended physical properties.

A fluorine-containing ether compound represented by the following formula (1) is provided.
R.sup.2CH.sub.2R.sup.1CH.sub.2OCH.sub.2CH(OH)(CH.sub.2).sub.nCH(OH)CH.sub.2OCH.sub.2R.sup.1CH.sub.2R.sup.2(1)
(in the formula (1), n is an integer of 2 to 6, R.sup.1 is a perfluoropolyether chain, R.sup.2 is OCH.sub.2CH(OH)CH.sub.2O(CH.sub.2).sub.mOH (m in the formula is an integer of 2 to 4)).

A polyethylene glycol-functionalized triglyceride polyol polymer comprising a glycerol component and three fatty acid components bonded to the glycerol component, wherein at least one of the fatty acid components comprises: a fatty acid chain; a hydroxyl functional group bound to a carbon atom of the fatty acid chain; and a polyethylene glycol-based functional group bound to an adjacent carbon atom of the fatty acid chain; according to Structure I ##STR00001##
wherein: n is from 10 to 40; and R is selected from the group consisting of H, alkyl, and silyl.