The disclosure provides a fluoropolyether compound represented by formula (1):
R.sup.1CH.sub.2R.sup.2CH.sub.2R.sup.3
wherein R.sup.1 is C.sub.1-C.sub.10 alkoxy; R.sup.2 is (CF.sub.2).sub.pO(CF.sub.2O).sub.x(CF.sub.2CF.sub.2O).sub.y(CF.sub.2CF.sub.2CF.sub.2O).sub.z(CF.sub.2CF.sub.2CF.sub.2CF.sub.2O).sub.w(CF.sub.2).sub.p; x and y are each a real number of 0 to 30; z is a real number of 0 to 30; w is a real number of 0 to 20; p is an integer of 1 to 3; R.sup.3 is OCH.sub.2CH(OH)CH.sub.2OH, OCH.sub.2CH(OH)CH.sub.2OCH.sub.2CH(OH)CH.sub.2OH, O(CH.sub.2).sub.mOH, or OCH.sub.2(OH)CHCH.sub.2OC.sub.6H.sub.4R.sup.4; m is an integer of 2 to 8; and R.sup.4 is hydrogen, C.sub.1-C.sub.4 alkoxy, amino, or an amide residue; and also provides a lubricant having the compound and a magnetic disk.

A fluorine-containing ether compound represented by the following formula (1) is provided.
R.sup.2CH.sub.2R.sup.1CH.sub.2OCH.sub.2CH(OH)(CH.sub.2).sub.nCH(OH)CH.sub.2OCH.sub.2R.sup.1CH.sub.2R.sup.2(1)
(in the formula (1), n is an integer of 2 to 6, R.sup.1 is a perfluoropolyether chain, R.sup.2 is OCH.sub.2CH(OH)CH.sub.2O(CH.sub.2).sub.mOH (m in the formula is an integer of 2 to 4)).

This disclosure relates to polymersomes comprising a crosslinked polymer and their use as drug delivery vehicles. Specifically, polymersomes comprising a polymer of Formula I:

##STR00001##

wherein each R is independently C.sub.1-6 alkyl; and n is an integer between 1 and 50.

There is provided a fluorine-containing ether compound represented by following formula: R.sup.1R.sup.2CH.sub.2R.sup.3[CH.sub.2R.sup.4CH.sub.2R.sup.3].sub.nCH.sub.2R.sup.5R.sup.6 (n is 1 or 2; R.sup.3 and R.sup.3 are a perfluoropolyether chain; R.sup.4 is a divalent linking group having one polar group; R.sup.2 and R.sup.5 are a divalent linking group having one or more polar groups; R.sup.2 has an oxygen atom at an end that is bonded to R.sup.1; R.sup.5 has an oxygen atom at an end that is bonded to R.sup.6; R.sup.1 and R.sup.6 in end group bonded to an oxygen atom at an end of R.sup.2 or R.sup.5; and R.sup.1 and R.sup.6 are an organic group having 1 to 50 carbon atoms, and at least one of them is a group in which a carbonyl carbon atom or nitrogen atom constituting an amide bond is bonded to a carbon atom of an organic group having 1 to 8 carbon atoms).

Provided herein are polymeric -hydroxy aldehyde or -hydroxy ketone reagents which can be conjugated to amine-containing compounds to form stable conjugates in a single-step reaction. In selected embodiments, the polymeric reagent itself incorporates an internal proton-abstracting (basic) functional group, to promote more efficient reaction. The substituent is appropriately situated, via a linker if necessary, to position the group for proton abstraction, preferably providing a 4- or 5-bond spacing between the abstracting atom and the hydrogen atom on the -carbon. Also provided are methods of using the reagents and stable, solubilized conjugates of the reagents with biologically active compounds. In preferred embodiments, the polymeric component of the reagent or conjugate is a polyethylene glycol.

The disclosure provides a fluoropolyether compound represented by formula (1):

R.sup.1CH.sub.2R.sup.2CH.sub.2R.sup.3

wherein R.sup.1 is C.sub.1-C.sub.10 alkoxy; R.sup.2 is (CF.sub.2).sub.pO(CF.sub.2O).sub.x(CF.sub.2CF.sub.2O).sub.y(CF.sub.2CF.sub.2CF.sub.2O).sub.z(CF.sub.2CF.sub.2CF.sub.2CF.sub.2O).sub.w(CF.sub.2).sub.p; x and y are each a real number of 0 to 30; z is a real number of 0 to 30; w is a real number of 0 to 20; p is an integer of 1 to 3; R.sup.3 is OCH.sub.2CH(OH)CH.sub.2OH, OCH.sub.2CH(OH)CH.sub.2OCH.sub.2CH(OH)CH.sub.2OH, O(CH.sub.2).sub.mOH, or OCH.sub.2(OH)CHCH.sub.2OC.sub.6H.sub.4R.sup.4; m is an integer of 2 to 8; and R.sup.4 is hydrogen, C.sub.1-C.sub.4 alkoxy, amino, or an amide residue; and also provides a lubricant having the compound and a magnetic disk.

Provided herein are polymeric -hydroxy aldehyde or -hydroxy ketone reagents which can be conjugated to amine-containing compounds to form stable conjugates in a single-step reaction. In selected embodiments, the polymeric reagent itself incorporates an internal proton-abstracting (basic) functional group, to promote more efficient reaction. The substituent is appropriately situated, via a linker if necessary, to position the group for proton abstraction, preferably providing a 4- or 5-bond spacing between the abstracting atom and the hydrogen atom on the -carbon. Also provided are methods of using the reagents and stable, solubilized conjugates of the reagents with biologically active compounds. In preferred embodiments, the polymeric component of the reagent or conjugate is a polyethylene glycol.

Gel-forming block copolymers were prepared comprising i) a central hydrophilic block consisting essentially of a divalent poly(ethylene oxide) chain and ii) two peripheral monocarbonate or polycarbonate hydrophobic blocks. The hydrophobic blocks comprise one or more vitamin-bearing subunits. The vitamin-bearing subunits comprise a carbonate backbone portion and a side chain comprising a covalently bound form of a vitamin. The gel-forming block copolymers can be used to prepare various biodegradable and/or biocompatible hydrogel and organogel drug compositions, in particular antimicrobial and/or anti-tumor drug compositions. The hydrogel compositions can be suitable for depot injections. Synergistic enhancement of toxicity to microbes was observed with compositions comprising an antimicrobial cationic polymer and an antimicrobial compound.

What is provided is a fluorine-containing ether compound represented by the following formula.
R.sup.1CH.sub.2R.sup.2CH.sub.2OCH.sub.2CH(OH)CH.sub.2OCH.sub.2R.sup.3CH.sub.2R.sup.4
(In the formula, R.sup.2 and R.sup.3 are perfluoropolyether chains, and R.sup.1 and R.sup.4 are terminal groups having two or three polar groups, in which individual polar groups are bound to different carbon atoms and the carbon atoms to which the polar groups are bound are bound to each other via a linking group having a carbon atom to which the polar groups are not bound).

Provided herein are polymeric -hydroxy aldehyde or -hydroxy ketone reagents which can be conjugated to amine-containing compounds to form stable conjugates in a single-step reaction. In selected embodiments, the polymeric reagent itself incorporates an internal proton-abstracting (basic) functional group, to promote more efficient reaction. The substituent is appropriately situated, via a linker if necessary, to position the group for proton abstraction, preferably providing a 4- or 5-bond spacing between the abstracting atom and the hydrogen atom on the -carbon. Also provided are methods of using the reagents and stable, solubilized conjugates of the reagents with biologically active compounds. In preferred embodiments, the polymeric component of the reagent or conjugate is a polyethylene glycol.