The present disclosure provides conjugates comprising a Factor VIII moiety covalently attached via an oxime-containing linkage to a water-soluble polymer, such as for example, a polyethylene glycol polymer. Methods for preparing and for administering such conjugates, are also provided, as are water-soluble polymer oxyamine reagents useful for preparing the subject conjugates, among other things.

Esters of polylactic acid, including polyethylene glycol esters of polylactic acid, that are coupled with an acid are disclosed. Exemplary coupled esters of polylactic acid can be used as textile finishes. Methods of making the coupled esters of polylactic acid via direct and/or transesterification reactions are also disclosed.

In general, the present invention is directed to a method of cooking wood in a cooking liquor medium. The method comprises a step of providing wood to a treatment vessel and contacting the wood with a digester additive composition. The composition comprises a first surfactant comprising an anionic surfactant, a derivative thereof, a salt thereof, or any combination thereof and a second surfactant comprising a polyoxyalkylene glycol or a derivative thereof. Additionally, according to another embodiment, the present invention is directed to a digester additive composition comprising a first surfactant comprising an anionic surfactant, a derivative thereof, a salt thereof, or any combination thereof and a second surfactant comprising a polyoxyalkylene glycol or a derivative thereof.

A method for producing a terminal carboxyl group-containing polyethylene glycol, which includes the following steps 1 and 2. Step 1: In a solution containing a polyethylene glycol having a hydroxyl group, an inorganic base 0.5 to 4 times the polyethylene glycol in mass, an aprotic solvent and water, mass of the water being 5 to 20 meq with respect to the inorganic base and mass of the water in the solution being 2,000 ppm or less, a compound of the formula (1) is reacted with the polyethylene glycol to obtain a polyethylene glycol ester:

##STR00001##

wherein X represents a leaving group, a represents an integer of 4 to 9, and R.sup.1 represents a hydrocarbon group having 1 to 4 carbon atoms; Step 2: The polyethylene glycol ester is hydrolyzed to obtain a terminal carboxyl group-containing polyethylene glycol.

Disclosed in the present invention is a method for preparing a Y-branched hydrophilic polymer carboxylic acid derivative, in particular a method for preparing a Y-branched polyethylene glycol carboxylic acid derivative having a high purity and high molecular weight. The preparation steps are simple, the product of the reaction is easy to be separated, the cost for separation is low, and the purity and yield of the product are high, facilitating the subsequent preparation of other derivatives and medicament conjugates based on the preparation of the carboxylic acid derivative, which is advantageous for industrial scale-up and commercial applications. The prepared Y-branched hydrophilic polymer carboxylic acid derivative (in particular the Y-branched polyethylene glycol carboxylic acid derivative having a high molecular weight) product has a high purity and high commercial application value, in particular in the use of the preparation of medicaments for preventing and/or treating diseases.

Provided are: an antistatic agent which can continuously impart an excellent antistatic effect to a synthetic resin and has excellent storage stability and productivity (cutting property); an antistatic agent composition containing the same; an antistatic resin composition containing the antistatic agent or the antistatic agent composition; and a molded article thereof. The antistatic agent contains at least one polymer compound (E) which is obtained by a reaction of a polyester (a) obtained by a reaction between a diol (a1) and a dicarboxylic acid (a2), a compound (b) containing at least one ethyleneoxy group and having hydroxy groups at both ends, and an epoxy compound (D) containing two or more epoxy groups. The diol (a1) is at least either of 1,4-butanediol and ethylene glycol, and the dicarboxylic acid (a2) is succinic acid or a dicarboxylic acid mixture containing succinic acid.

The present invention provides a method for producing a hetero-type monodisperse polyethylene glycol, which includes a step (A) of carrying out a nucleophilic substitution reaction between a compound of the formula (2) and a compound of the formula (3) so as to satisfy the requirement of the expression (F1) to obtain a compound of the formula (4), a step (B) of carrying out the Michaels addition reaction of a compound of the formula (5) to the compound of the formula (4) at a temperature condition of 10° C. or lower to obtain a compound of the formula (6), a step (C) of detritylating or debenzylating the compound of the formula (6) to obtain a reaction product containing a compound of the formula (7), a step (D) of purifying the compound of formula (7) from the reaction product, a step (E) of reacting the compound of the formula (7) with phthalimide and performing dephthalimidation to obtain a compound of the formula (8), and a step (F) of subjecting the compound of formula (8) to an acid hydrolysis treatment to obtain a compound represented by the formula (1).

The present disclosure provides conjugates comprising a Factor VIII moiety covalently attached via an oxime-containing linkage to a water-soluble polymer, such as for example, a polyethylene glycol polymer. Methods for preparing and for administering such conjugates, are also provided, as are water-soluble polymer oxyamine reagents useful for preparing the subject conjugates, among other things.

Among the various aspects of the present disclosure is the provision of compositions of mechanically interlocked, topologically complex crosslinkers and polymers and methods of making and using same.

A cross-linked copolymer is provided, including at least repeating units of poly(alkylene oxide) and at least repeating units of lithium polystyrene-sulfonyl(trifluoromethylsulfonyl)imide (PSTFSILi), as well as the use of such a cross-linked copolymer for preparing a solid polymer electrolyte, a solid polymer electrolyte having the cross-linked copolymer, and a battery, for example a lithium metal polymer (LMP) battery, including the solid polymer electrolyte.