The present invention relates to new methods for crosslinking a polysaccharide with a bifunctional poly(ethylene glycol). The invention further includes the polymer hydrogels which can be produced using these methods, compositions comprising the polymer hydrogels and methods of use thereof.

The present invention relates to micellar nanocomplexes and a method of forming the same. The micellar nanocomplex comprises a micelle and an agent encapsulated within said micelle, where the micelle comprises a polymer-flavonoid conjugate, wherein said polymer is bonded to the B ring of said flavonoid. The micellar nanocomplex may have useful applications as a drug-delivery system.

Among other aspects, provided herein are multi-armed polymer conjugates comprising an alkanoate-linker, compositions comprising such conjugates, and related methods of making and administering the same. Methods of treatment employing such conjugates and related uses are also provided. The conjugates are prepared with high drug loading efficiencies.

A photo curable ink composition includes a photo-reactive binder, a water soluble polymeric sensitizer, a water soluble photoinitiator, a colorant, and a balance of water. The water soluble polymeric sensitizer includes a functionalized anthrone moiety, a polyether chain, and an amide linkage or an ether linkage attaching one end of the polyether chain to the functionalized anthrone moiety. The water soluble photoinitiator having a formula (I) of: wherein n is any integer from 1 to 5 and M is a metal with a valence from 1 to 5.

The present disclosure provides amphiphilic fluorinated surfactant molecules for lowering the surface tension of aqueous, hydrocarbon, or solid phases in the presence of a fluorophilic continuous phase and for selectively interacting with biological and/or chemical molecules.

This disclosure relates to polymersomes comprising a crosslinked polymer and their use as drug delivery vehicles. Specifically, polymersomes comprising a polymer of Formula I:

##STR00001##

wherein each R is independently C.sub.1-6 alkyl; and n is an integer between 1 and 50.

In some aspects, the present disclosure provides reactive polymers that comprise one or more hydrophilic polymer segments having a plurality of hydrophilic polymer segment ends and a plurality of reactive moieties covalently linked to at least a portion of the hydrophilic polymer segment ends. The reactive moieties are 3,4-substituted-2,5-pyrrolidinedione moieties in which the 3-carbon and the 4-carbon form part of at least one ring in addition to the 2,5-pyrrolidinedione ring, and the 2,5-pyrrolidinedione ring nitrogen atom of each of the 3,4-substituted-2,5-pyrrolidinedione moieties is linked to one of the hydrophilic polymer segment ends. In other aspects, the present disclosure provides systems for forming hydrogel compositions and methods of treatment that employ such reactive polymers and methods of synthesizing such reactive polymers.

Compositions for corrosion inhibitions, methods of making a chemically modified, maleated unsaturated fatty acids and salts thereof corrosion inhibitor, and methods of using the same are disclosed to provide alternatives for corrosion inhibition under harsh conditions with improved performance.

Among other aspects, provided herein are multi-armed polymer conjugates comprising an alkanoate-linker, compositions comprising such conjugates, and related methods of making and administering the same. Methods of treatment employing such conjugates and related uses are also provided. The conjugates are prepared with high drug loading efficiencies.

The present disclosure generally relates to a multifunctional additive obtained from the reaction of: (a) an intermediate obtained from the reaction of maleic anhydride and a polyoxyalkylene monoamine; and (b) an amine compound comprising a primary amine group and/or a secondary amine group and its use in a variety of applications, including, but not limited to: as a corrosion inhibitor or friction modifier in aqueous and non-aqueous systems; in fuel deposit control agents; as a dispersant in pigment, asphalt and cement compositions; and as a detergent.