A method for producing a hetero-type monodisperse polyethylene glycol, which includes (A) carrying out a nucleophilic substitution reaction between a compound of formula (2) and a compound of formula (3) so as to satisfy expression (F1) to obtain a compound of formula (4), (B) of carrying out a Michaels addition reaction of a compound of formula (5) to the compound of formula (4) at a temperature condition of 10? C. or lower to obtain a compound of formula (6), (C) detritylating or debenzylating the compound of the formula (6) to obtain a reaction product containing a compound of formula (7), (D) purifying the compound of formula (7) from the reaction product, (E) reacting the compound of formula (7) with phthalimide and performing dephthalimidation to obtain a compound of formula (8), and (F) subjecting the compound of formula (8) to an acid hydrolysis treatment to obtain a compound represented by formula (1).

A method for the manufacture of fluorinated polymers and polymers obtainable therefrom are herein disclosed. The method envisages the reaction of a) first reagent [reagent (R1)] which is an alcohol selected from a (per)fluoropolyether (PFPE) alcohol a fluoroalkylene diol and a mixture thereof; b) a second reagent [reagent (R2)] which is a sulfonic ester of a PFPE, a sulfonic diester of a fluoroalkylene diol or a mixture thereof and, optionally, c) a third reagent which is a mono-functional (per)haloalkyl alcohol or a sulfonic ester thereof in the presence of an organic or inorganic base. At least reagent (R1) is a PFPE alcohol (A) or at least reagent (R2) is a PFPE sulfonic ester (B) and the overall equivalents of alcohols are the same as the overall equivalents of sulfonic esters. The method allows to obtain in a convenient way non-functional polymers comprising at least a PFPE segment and having high molecular weight.

The present invention relates to an improved method for preparing a high purity polyethylene glycol dialdehyde derivative. The preparation method can provide the polyethylene glycol dialdehyde derivative suitable as a raw material for pharmaceuticals because of high purity and terminal activity, by using PEG-diacetal, which is prepared by reacting polyethyleneglycol methanesulfonate with dialkoxy-1-propanol, as an intermediate.

A polyalkylene glycol derivative with a minimal impurity content is prepared simply by the steps of reacting a compound having formula (III-I) or (III-II) with an electrophile having formula (IV) in the presence of an optional basic compound, to form a reaction solution containing a compound having formula (V), and passing the reaction solution through a column of cation and anion exchange resins to remove water-soluble impurities, for thereby purifying the desired polyalkylene glycol derivative.

R.sup.1R.sup.2OR.sup.3O.sub.n-1R.sup.3O.sup.M.sup.+(III-I)

R.sup.1R.sup.2OR.sup.3O.sub.n-1R.sup.3OH(III-II)

R.sup.4R.sup.5X(IV)

R.sup.1R.sup.2OR.sup.3O.sub.nR.sup.5R.sup.4(V)

The invention relates to a method for preparing polyarylethersulfone-polyalkylene oxide block copolymers (PPC) comprising the polycondensation of a reaction mixture (R.sub.G) comprising the components: (A1) at least one aromatic dihalogen compound, (B1) at least one aromatic dihydroxyl compound, (B2) at least one polyalkylene oxide having at least two hydroxyl groups, (C) at least one aprotic polar solvent and (D) at least one metal carbonate,
where the reaction mixture (R.sub.G) does not comprise any substance which forms an azeotrope with water.

Provided herein are polymers obtainable by a process including the steps a) and b) described below. In Step a) at least one component a1) is condensed to obtain a polyether having remaining hydroxyl groups. Component a1) is at least one component selected from N-(hydroxyalkyl) am ins according to formula (Ia) and/or (Ib) as defined below. Besides component a1), further components can be present in the condensation step a). In step b) a part of the remaining hydroxyl groups are reacted with at least one alkylene oxide. The alkoxylation according to step b) is carried out in a substoichiometric way. The ratio of i) the alkylene oxide versus ii) the sum of the amount of the remaining hydroxyl groups is >0:1 to <1:1 [mol/mol]. Further provided herein is a process for preparing such polymers and derivatives of the polymers by quaternization, protonation, sulphation and/or phosphation.

Block copolymer comprising polyarylene ether blocks and polyalkylene oxide blocks, wherein said block copolymer comprises at least two polyalkylene oxide blocks that are endcapped with different endcapping groups.

(Per)fluoropolyether polymers comprising a (per)fluoropolyether chain having two ends, wherein one or both ends comprise one or more zwitterionic groups at one or both polymer ends, methods for their manufacture and uses thereof are herein disclosed. The polymers can be used in particular for protecting materials in contact with biological fluids or fluids containing biological material from contamination by organic compounds therein contained.

Methods for preparing water soluble, non-peptidic polymers carrying carboxyl functional groups, particularly carboxylic acid functionalized poly(ethylene glycol) (PEG) polymers are disclosed, as are the products of these methods. In general, an ester reagent R(CO)OR, wherein R is a tertiary group and R comprises a functional group X, is reacted with a water soluble, non-peptidic polymer POLY-Y, where Y is a functional group which reacts with X to form a covalent bond, to form a tertiary ester of the polymer, which is then treated with a strong base in aqueous solution, to form a carboxylate salt of the polymer. Typically, this carboxylate salt is then treated with an inorganic acid in aqueous solution, to convert the carboxylate salt to a carboxylic acid, thereby forming a carboxylic acid functionalized polymer.

A polyarylene ether copolymer comprising i) at least one block comprising in polymerized form A) isosorbide, isomannide, isoidide or a mixture thereof and B) at least one unit comprising at least one difunctional compound comprising at least one dichlorodiaryl sulfone, a dichlorodiaryl ketone or a mixture thereof and ii) at least one block comprising in polymerized form C) at least one polyalkylene oxide, a process for its preparation and its use in the preparation of coatings, films, fibers, foams, membranes or molded articles.